Miscellaneous Virology

Question 1

Mechanism of HPV?

Answer 1

viral inactivation of cellular tumor suppressor gene

Question 2

treat CMV with…

Answer 2

gencyclovir

Question 3

lethal encephalitis associated with…

Answer 3

measles

Question 4

most common viral cause of sporadic encephalitis is…

Answer 4

HSV1

Question 5

EEV most commonly appears when?

Answer 5

focal outbreaks during summer

Question 6

Pt in africa. presents with swelling in neck and jaw, blood + for heterophile antibody. test for what?

Answer 6

HIV and malaria

Question 7

SV40 virus in polio vaccine…. what is possible prolem?

Answer 7

could cause cancer via alteration of tumor suppressor gene

Question 8

Rous sarcroma causes cancer how?

Answer 8

proto-oncogenes

Question 9

CMV is transmitted how…

Answer 9

fecal-oral route. wash hands after diaper changes!

Question 10

What is least effective immune response against extracellular bacterial pathogens?

Answer 10

cytotoxic T cells

Question 11

a delayed hypersensitivity reaction to PCN would take how long?

Answer 11

7 days

Question 12

problems with bone marrow transplant

Answer 12

graft v host disease, host cells are replaced by donor cells

Question 13

how can the lineage of leukeia cells be determined?

Answer 13

by tumor CD antigens

Question 14

a tumor expressed by a papilloma virus expresses:

Answer 14

unique TSA, and same tumor antigens as another tumor induced by a papilloma virus

Question 15

delayed hypersensitivity reactions are most often characterized by..

Answer 15

an infiltrate composed of T helper cells and macrophages

Question 16

inflammation caused by immune compleses: requires what response?

Answer 16

neutrophils, and involves IgG and IgM

Question 17

how quickly will macrophages produce TNF

Answer 17

within a few mins to an hour

Question 18

what form of vaccine is most likely to induce CTL response?

Answer 18

modified life-measles vaccine

Question 19

immune complexes can trigger platelet activation: T or F?

Answer 19

True

Question 20

HLA disease association in autoimmunity may in soem cases be useful for diagnosis

Answer 20

hmm

Question 21

with a second exposure to poison ivy, what will contribute to inflamation?

Answer 21

TNFalpha

Question 22

Patients who lack C5-C9 have a high incidence of infection caused by what

Answer 22

Neisseria (bacterium)

Question 23

complement receptors on RBCs faciliate what?

Answer 23

elimination of immune complexes by phagocytic cells

Question 24

does coxsackie virus present with diarrhea, vomiting?

Answer 24

NO

Question 25

can polio vaccine mutate?

Answer 25

yes, reason why live attenuated is sometimes not given?

Question 26

alpha interferon: contributes to hepatitis clinical outcome how?

Answer 26

upregulates cellular kinase

Question 27

If get a needle stick from a patient with Hep B and Hep C, what is your main concern?

Answer 27

50% chance Hep C. Use a triple-drug cocktail

Question 28

Rotavirus. describe genome and freq of recomb

Answer 28

mult segments of dsDNA. freq recomb

Question 29

where does polio replicate?

Answer 29

cytoplasm of infected cells

Question 30

How would you diagnose Hep B (mild form that does not result in long term liver damage)

Answer 30

IgM antibody levels

Question 31

what causes an antigenic shift?

Answer 31

reassortment of different RNA segments in genome

Question 32

how would I distinguish croup v influenza?

Answer 32

structure of the genome

Question 33

do we routinely inject children with rotavirus vaccine?

Answer 33

yes

Question 34

if a child is exposed to Hep A, would that result in lifelong immunity?

Answer 34

yes

Question 35

with Hep E, will the feces contain a high number of virions?

Answer 35

yes

Question 36

Test results to interpret: NL AST. negative HBeAG and HBSAG. Positive antibodies to HBeAG and HBsAg

Answer 36

Conclusion: HepB infection with subsequent recovery.

Question 37

what organ is both primary and seconday lymphoid organ?

Answer 37

bone marrow

Question 38

what is the primary signalling component associated with the T cell receptor?

Answer 38

CD3

Question 39

what does NOT inhibit the complement cascade?

Answer 39

Factor B

Question 40

TH1 cells produce what, and do what kind of immunity?

Answer 40

produce IFN gamma, and are part of cell-mediated imm

Question 41

TH2 cells produce what, and do what kind of imm?

Answer 41

IL4, and antibody mediated imm

Question 42

IgE: evolved to be anti-helminth

Answer 42

ok

Question 43

an example of molecular cross-reactivity?

Answer 43

strep/rheumatic fecer

Question 44

during what stages of B cell dev can tolerance most easily be developed?

Answer 44

immature cell stage, mature cell stage

Question 45

IgG diversity will not be created by...

Answer 45

class switching

Question 46

cell of the innate imm system do NOT respond to antigen by

Answer 46

clonal expansion

Question 47

what do Treg cells to to T cell activation in the periphery?

Answer 47

control it

Question 48

the primary APCs that initiate activation of naive T cells are?

Answer 48

DCs

Question 49

The processing of an antigen for MHC I presentation involves what?

Answer 49

a proteosome and the invariant chain

Question 50

CD28 binds to what to provide cell costimulation?

Answer 50

CD80

Question 51

if you have a defective poly Ig receptor, you will get recurrent bacterial infections at mucosal sites

Answer 51

ok

Question 52

T and B cells use what to exit from blood to lymph nodes?

Answer 52

HEVs

Question 53

a defect in CD154 will result in what?

Answer 53

defective B cell activation, and no IgG in serum

Question 54

The process of T cell development depends on what?

Answer 54

TCR binding to MHC molecules