mitochondria: energy Flashcards

(43 cards)

1
Q

describe the structure of a mitochrondrai

A

high specialised with an outer an inner membrane

inner one is hihgly folded

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2
Q

whats special about the inner membrane

A

full of cardiolipin which makes the membrane impereable to ions
this is a hihgly specialsed lipid bilayer

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3
Q

what does the mitochondria matrix contain

A

enzymes that metabolise pyruvate and fatty acids to produce acetyl CoA and enzymes that oxidise citric acid cycle

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4
Q

what is reduction andd oxidation

A

reduction is adding/gain

oxidation is removing/loss

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5
Q

how is FAD reduced?

A

addition of 2 electrons and protons

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6
Q

what is oxidative photphylation

A

glucose can be metabolised through oxidation to produce energy in glycolysis

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7
Q

where does oxidative phosophylation in glycolysis happen>

A

in the cytosol

glucose is broken down to produce energy as ATP

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8
Q

how many atp can one molecule of glucose produce

A

2ATP

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9
Q

where does the citric acid cycle occur?

A

in the matrix

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10
Q

what does the citric acid cycle produce

A

electron carriers such as NADH for electron transport chain

building blocks for cells and ATP

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11
Q

what are fed into the citric acid cycle?

A

fatty acids, amino acids, sugars

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12
Q

what are transfered to the electron transport chain?

A

NADH and FADH

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13
Q

how are electrons passed in the transport chain to fnally oxygen>

A

passed through number of prteins including cytochromes wth an iron atom to finally reach oxygen

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14
Q

what does the electron chain function to do?

A

break the large free-energy drop from food to oxygen into smaller steps that release manageable energy in smaller bits

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15
Q

what helps transfere the electrons from NADH to oxygen exactly?

A

large respiratory enzyme complexes located in the inner membrane of the mitochondria
work through a series of alternate reduction and oxidation steps

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16
Q

where does the electron transport chain occur

A

in the cristae

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17
Q

desribe the process of the electron in the chain

A
  • NADH passes electron to first part of the chain
  • NADH dehydrogenase is first complex ]
  • NADH oxidised to NAD+
  • complex reduced now
  • now electron passed to ubiquinone Q
  • quinnone reduced and is oxidised
  • cycle to redox reactions
  • passed onto cytochrome BC1
  • passed onto final cytochrome oxidase
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18
Q

name the enzyme cpmplexes in the electron chain

A
NADH dehydogenase ( large complex)
ubiquinone Q
cytochrome BC1 ( large complex)
cytochome C
cytochrome oxidase ( Large complex)
19
Q

what us the importance of oxygen?

A

this is what 90% of the oxygen we breath in used for, final electron acceptor

20
Q

why is cytochrome C important

A

key for cell death as well as electron transport energy production

21
Q

what does cyanide do to the body?

A

toxic as it binds to cytochrom oxidase complex, stopping electron transport and reducing ATP production

22
Q

name some carriers of electrons only

A

FeS iron sulphur proteins

cytochromes

23
Q

nanme some carriers of electrons and H+ ions

A

FMN: flavin mononucleotide
FAD
uniquinnone Q
oxygen

24
Q

where are protons moved to in the electrons transport chain?

A

moved into the intermembrane space out of the matrix creating a gradient

25
why cant the protons move back across the membranes in electron transport?
the inner membrane is impermeable to ions | they et stuck on the other side creating the gradient
26
what is the final component of electron transport chain??
ATP synthase
27
what is ATP synthase
channel that carries protons moving the protons through here synthesies ATP the force of the protons drives the production of ATP
28
describe the structure of ATP synthase
little channels on the top protons flow into channels and out the other side protosn twist the molecule, this mechanical twisting makes the ATP
29
what is ATP synthase an example of?
chemiosmosis
30
describe the process of chemiosmoso
the enery coupling mechanism proteins pump hydrogen ions from mitochondria matrix to intermembrane space H ions then move back across through ATP synthase drives ADP into ATP * use of enery is a H+ gradient to drive cellular work
31
which part of respiration makes the most ATP
electron transport chain: 38 molecules from one molecule of glucose
32
what is mitochondria uncoupling?
controlling the efficiency of the process
33
what happens in mitochondria uncoupling
break the cycle | instead of pumping protons to synthase, the membrane is made leaky and protons can flow out losing energy as heat
34
what is used in mitochondrial uncoupling to make the membrane leaky?
DNP
35
what is uncoupling proteins UCPs
mitochondria transporter present in the inner membrane | found in mammals and plants
36
what does as UCP allow
continuous rexoidation of coenzymes that are essential to metabolic pathways
37
what is the function of a UCP (uncoupling proteins)
help make more heat | retain temperture
38
is the body priority is heat generation, what happens to repiration?
this becaome uncoupled and there is ots of heat generaton
39
is the bodys priotiry is heat generation what happens
the mitochondra becomes leaky and heat is lost
40
is the bodys priority is energy conservation what happens?
respiration is well-coupled and the protons are not leaky
41
in cold places what do you do to respiartion?
uncouple to make more heat
42
how is ATP synthesised in bacteria
respiration: | pump the protons outwards allowing them to re-enter via ATP synthase
43
what is the evidence for ATP snthesis in bacteria
the make it the same as we do in mitochdonria | explains endosymbiosis