Mitosis Flashcards
(23 cards)
DNA
Deoyribosenucleic Acid
Stores hereditary information within cells of all living organisms
DNA Structure
Double helix structure with hydrogenate bonds between complementary base pairs
Adenine - Thymine (A-T)
Cytosine - Uracil (C-G)
DNA Helicase
Breaks hydrogen bond between complementary base pairs
Topoisomerase
Unwinds supercoiled DNA and a single stranded binding protein prevents hydrogen bonds reforming
Primase
Binds a small length of RNA (a primer) to the DNA
DNA Polymerase
Travels down the DNA strand adding DNA nucleotides to the template strand
DNA Ligase
catalyses the condensation reaction to reform the sugar phosphate backbone between DNA nucleotides
Fidelity
The degree of exactness to which something is copied or reproduced
High dNTP levels
detrimental to the fidelity f replication as speed up repilcation
Low dNTP Levels
inhibit DNA replication allowing for mismatch repair to decrease the chance of mutation
Exonuclease
Travels in a 3’-5’ direction removing incorrect nucleotides
Direct Reversal
some DNA damaging reactions can be undone by enzymes in the cell
Excision Repair
the incorrect bases are removed and the damaged region is replaced
Telomerase
Allows cellular DNA to continues replication when there is an incomplete lagging strand
Mitosis
The production of genetically identical diploid cells for growth and repair.
G1 Phase
Metabolic changes prepare the cell for division and it passes the restriction point and the cell commits and moves to S Phase
S Phase
DNA replication occurs and each chromosome is made up of two genetically identical sister chromatids
G2 Phase
The cell assembles organelles and cytoplasmic material necessary for mitosis
M Phase
Actual cell division- made up of Prophase, metaphase, Anaphase and Telophase
Prophase
Chromosomes condense and appear visible, the nuclear envelope breaks down and the spindle fibres form
Metaphase
Chromosomes line up along the equator of the cell and attach to the spindle fibres
Anaphase
The spindle fibres contract and the centromeres divide, sister chromatids move to opposite poles of the cell
Telophase
The nuclear envelope reforms and the chromatids de condense to form sister chromatids and cytokinesis occurs.