Mixed Flashcards
(22 cards)
Prognostic determinant for MDS and AML
MDS - Blast percentage
AML - Cytogenetic abnormalities
Chromosomal involvement in Alkylating agents and Topoisomerase II inhibitors
alkylating - 5 & 7
topoisomerase - 11
Minimum amount of iron to correct IDA
500 mg
Disease defined by MCHC > 34
Hereditary spherocytosis
2 microscopic features of megaloblastic anemia
Oval macrocytes
Segmented neutrophils
Cytogenetic abnormality in APL
t (15:17)
B-cell makers; T cell markers
CD 19, 20, 22, 23
CD5
CLL is associated with cancers and autoimmune infections. What are the associated cancers?
SBP
Skin
Breast
Prostate
Define Richter’s transformation
Transformation of CLL to DLBCL
RAI and BINET staging
RAI
Stage I (Low risk) - Lymphocytosis
Stage II/III (Intermediate) - Lymphocytosis and Lymphadenopathy
Stage IV (High) - Lymphocytosis, thrombocytopenia/anemia
BINET
A - < 3 LAD
B >= LAD
C Hgb < 10 and plt < 100, 000
Target Plt for CNS bleed
> 100
Severe thrombocytopenia in ITP
plt < 30
Tx of choice for severe ITP
Steroids and IVIG
Refractory: Rituximab
Pathogenesis of TTP
Decreased ADAMTS13
Mainstay if TTP management
Plasmapheresis until Plt normalizes for 2 days
Medication that can be given for aHUS
eculizumab
When to treat CLL?
Symptomatic, meaning
> 6cm splenomegaly
=10 LAD
Autoimmune anemia/thrombocytopenia
Weight loss 10% in 6 months, fever, night sweats > 1 month
Progressive marrow failure
Target Hgb and Hct in PV to avoid complications
M: Hgb < =140 Hct < 45
F: Hgb < =120 Hct < 42
Percentage of blood loss with orthostatic hypotension
30%
Formula for RPI
[Retic count % x (Hgb pt/Hgb normal)] / 2
What is the most common cause of non-iatrogenic thrombocytopenia?
Infection
What is the most common cause of non-iatrogenic thrombocytopenia?
Infection
