Mixed Flashcards
Diagnosis of APAS pregnancy morbidity
- Three or more unexplained consecutive spontaneous abortions < 10th week of AOG
- One or more unexplained deaths of a morphologically normal fetus at or beyond the tenth week AOG (>/ 10 weeks AOG)
- One or more premature births of a morphologically normal neonate </ 34th week AOG due to ECLAMPSIA, SEVERE PRE-ECLAMPSIA, or PLACENTAL INSUFFICIENCY
False positive APAS results
Syphilis
Cholesterol complexes
Diagnosis of EGPA
Asthma
Peripheral eosinophilia > 10%
Vasculitis
Test of choice for chronic granulomatous disease
Dihydrohodamine fluorescence assay
Howell Jowell bodies indicate what disease?
Asplenia
Management of DRESS
1) Drug cessation
2) Steroids 1-2 mg/kg/day
Duration to when symptoms appeaR:
-Serum sickness
-DRESS
-AGEP
-Anaphylaxis
-Morbilliform
-SJS Ten
Serum sickness: 6-12 days
-DRESS: 2-6 weeks
-AGEP: 2-4 days
-Anaphylaxis: minutes to hours
-Morbilliform: 4-14 days
-SJS TEN: 5-28 days
-SJS
Risk factors for drug reactions
-Elderly
-Autoimmune diseases
-Transplant receipients
-EBV and HIV
Risk factors for drug reactions
-Elderly
-Autoimmune diseases
-Transplant receipients
-EBV and HIV
The MC presentation of anaphylaxis
Urticarial eruptions
Serum levels of what test correlate with severity of anaphylaxis?
Platelet activating factor
Degranulation: Mast cells, basophil, histamine, TNF alfa
Contraindication to immunotherapy
Unstable heat disease and uncontrolled BA
*Be wary of intake of BB and ACEi/ARB
Symptoms of mastocytosis
Flushing , tachycardia, vascular collapse, abdominal pain, diarrhea with marrow biopsy of mast cell infiltrates
Features of hereditary angioedema
No pruritic lesions BUT gastrocolic + laryngeal edema
Management of HAE
Infusion opf C1INH protein + bradykinin 2 receptor antagonist (Icatibant)
If unavailable, BT FFP
