MKSAP Flashcards
(28 cards)
Malignant melanoma follow up
- Bresblow depth of <1mm and successful resection - follow up in 12 months
- metastatic melanoma- for BRAF mutations can use BRAF inhibitors, such as vemurafenib and dabrafenib, otherwise can use check point inhibitors
Hydroxiurea compliance
Check for macrocytosis
Metastatic lung adenocarcinoma
Can check for PDL-1 mutation for pembro
Metastatic prostate cancer therapy
for patients with new bone leasions, start therapu=y with an antiandrogen such as biclutatide prior to GnRH agonist luprolide because luprolide can transiently worsen symptoms
Erlotinib
Erlotinib is indicated for treatment of metastatic non–small cell lung cancer in patients with an EGFR mutation.
crizotinib.
ALK translocations and ROS1 mutations derive similar benefit from crizotinib in metastatic NSCLC
SLE refractory to all traditional treatments
add Belimumab - B lymphocyte stimulator protein antagonist
Double posative ANCA
Think drug induced
changes to lamotrogine when starting a oral contraceptive
increase it, oral contraceptives increase the metabolism
cutaneous abscess
incision and drainage. No antibiotic treatment unless there are systemic signs of illness
mild TBI
neuropsych testing before return to play
indications for aortic valve replacement
For patients with severe aortic regurgitation, surgical aortic valve replacement is recommended in the presence of symptoms attributable to regurgitation, left ventricular ejection fraction less than 50%, or another indication for cardiac surgery. In addition, surgical aortic valve replacement can be beneficial in asymptomatic patients with significant left ventricular dilatation (end-systolic dimension >50 mm or indexed end-systolic dimension >25 mm/m2). In the absence of these findings, clinical evaluation and surveillance echocardiography every 6 to 12 months is recommended.
Therapy for MS mobility impairments
dalfampridine, a voltage-gated potassium channel antagonist, significantly improved timed 25-foot walking speeds in patients with multiple sclerosis and gait impairment.
alcoholic ketoacidosis
don’t necessarily have to have ketones in urine
Hemochromotosis with elevated liver chemistries
get a biopsy
premature ejactulation
SSRI
Vaccienes needed prior to starting TNF alpha inhibitors
Herpies zoster to prevent disseminated disease and post herpatic neuroalgia
voriconazole complications
skin cancer with prolonged use
subepithelial collagen band on colon biopsy
microscopic colitis, treat with budesonide
Medications that need to be discontinued prior to secondary causes of hypertension workup
Spiro/epleronone, amitriptoline (causes falsely elevated metanephrines)
work up of breast mass in pt’s >30y/o
mammo and US despite breast density
D-lactic acidosis
Think in people wit anion gap and hx of malabsorption or small bowel resection
Pt’s will present with confusion and ataxia
chrons flare despite previous pred tapers
infliximab
which antiepileptic does not cause bone loss
lamotrogine
