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MOA /trade name/class Flashcards

(59 cards)

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1
Q

Albuterol Sulfate trade name / class

A
  • Proventil
  • Sympathomimetic , bronchodilator, beta-2 agonist
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2
Q

Albuterol Sulfate MOA (4)

A
  • Relatively selective beta2 adrenergic bronchodilator
  • Beta2 agonist that relaxes bronchial smooth muscle, resulting in bronchial dilation
  • Some beta1 overlap with tachycardia
  • Shift potassium intracellular, resulting in lower serum potassium
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3
Q

Racemic Epinephrine MOA (2)

A
  • Acts as bronchodilator that stimulates beta-2 receptors in lungs, relaxing brochial smooth muscle
  • Also useful in treating laryngeal edema
  • Inhibits release of histamine
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4
Q

Ipratropium Bromide trade name / class

A
  • Atrovent
  • Anticholinergic, bronchodilator
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5
Q

Ipratropium Bromide MOA (1)

A
  • Antagonizes action of Ach on the bronchial smooth muscle in the lungs, causing bronchodilation
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6
Q

Magnesium Sulfate MOA (4)

A
  • Smooth muscle relaxant
  • Decreases early after depolarizations and reduces arrhythmias
  • Decreases seizures in eclampsia and preeclampsia, possibly via cerebral vasodilation
  • CNS depressant
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7
Q

Methylprednisolone trade name / class

A
  • Solu-medrol
  • Glucocorticoid
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8
Q

Methylprednisolone MOA (2)

A
  • Potent synthetic steroid that inhibits many substances that cause inflammatory response
  • Controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorhonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level
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9
Q

Morphine Sulfate trade name / class

A
  • Astramorph PF
  • Opioid analgesic
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10
Q

Morphine Sulfate MOA (5)

A
  • Narcotic analgesic
  • Alleviates pain by acting on the pain receptors in the brain, elevates pain threshold
  • CNS depressant, depresses brainstem respiratory centers
  • Increases venous pooling, vasodilates arterioles, reducing preload and afterload
  • Histamine release
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11
Q

Naloxone MOA (2)

A
  • Naloxone is a narcotic antagonist which competitively binds to opioid receptors in the brain
  • Displaces opioid molecules, reversing the effect of opioids on the brain
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12
Q

Nitroglycerin trade name / class

A
  • Nitrostat
  • Vasodilator
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13
Q

Nitroglycerin MOA (6)

A
  • Potent smooth muscle relaxant
  • Causes systemic venodilation, decreasing preload
  • Arterial vasodilation, decreasing afterload
  • Coronary artery vasodilation
  • Increases blood flow to the myocardium
  • Decreases myocardial oxygen demand
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14
Q

Succinylcholine trade name / class

A
  • Anectine
  • Neuromuscular blocker (depolarizing)
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15
Q

Succinylcholine MOA (3)

A
  • Depolarizing neuromuscular blocker
  • Acts on the motor end plate receptors, producing depolariztion or fasciculations, and inhibiting subsequent neuromuscular transmission for the duration of the medication (short acting)
  • Muscles are unable to be stimulated by Ach
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16
Q

Ketamine trade name / class

A
  • Ketalar
  • Nonbarbiturate anesthetic
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17
Q

Ketamine MOA (2)

A
  • Non-competitive NMDA receptor antagonist
  • Functions as dissociative, amnestic, analgesic, anesthetic agent
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18
Q

Etomidate trade name / class

A
  • Amidate
  • Nonbarbiturate hypnotic, anasthetic
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19
Q

Etomidate MOA (3)

A
  • Sedative and hypnotic
  • Acts similar to GABA by depressing the activity of brain stem reticular activating system
  • No analgesic properties
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20
Q

Midazolam trade name / class

A
  • Versed
  • Short-acting benzodiazepine; anticonvulsant; anxiolytic
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21
Q

Midazolam MOA (1)

A
  • Benzodiazepine that functions as CNS depressant, anticonvulsant, and sedative
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22
Q

Phenylephrine MOA (1)

A
  • Stimulates alpha receptors in the blood vessels of nasal mucosa which causes their constriction and thereby decreases the risk of nasal bleeding
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23
Q

Dexamethasone trade name / class

A
  • Decadron / Hexadrol
  • Glucocorticoid
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24
Q

Dexamethasone MOA (4)

Study These Flashcards
A
  • Improves lung function and myocardial performance
  • Stabilization of lysosomal and cell membranes, inhibition of compliment-induced granulocyte aggregation
  • Rightward shift in oxygen-hemoglobin dissociation curve
  • Inhibition of prostaglandin and leukotriene production, increase in surfactant production, decrease in pulmonary edema, relaxation of bronchospasm
25
Diphenhydramine trade name / class
- Benadryl - Antihistamine
26
Diphenhydramine MOA (2)
- Histamine H1-receptor antagonist (blocks histamine receptors) of effector cells in respiratory tract, blood vessels, and GI smooth muscle - Also has anticholinergic actions, making it useful in treating or preventing acute dystonic reactions to antipsychotic drugs. These reactions include: oculogyric crisis, acute torticollis, and facial grimacing
27
Magnesium Sulfate class
Electrolyte / Anticonvulsant / Class V Antidysrhythmic
28
Racemic Epinephrine trade name / class
- Micronefrin - Sympathomimetic
29
Naloxone trade name and class
- Narcan - Opioid antagonist
30
Atropine Sulfate trade name and class
- Atropine - Anticholinergic agent
31
Atropine MOA (4)
- Blocks action of Ach as competitive antagonist at muscarinic receptor sites in smooth muscle, secretory glands, and CNS - Blocks parasympathetic response - Positive chronotropic properties with little to no inotropic effects (increases conduction through AV node) - Atropine reverses muscarinic effects of cholinergic poisoning
32
Vasopressin trade name and class
- Vasostrict - Vasoactive agent, antidiuretic hormone analog
33
Vasopressin MOA (2)
- Stimulates V1 receptor increasing systemic vascular resistance and MAP - Stimulates V2 receptor decreasing urine volume
34
Lidocaine trade name and class
- Xylocaine - Class I Antidysrhythmic
35
Lidocaine MOA (3)
- Antiarrhythmic that decreases automaticity by slowing rate of depolarization - Terminates re-entry by decreasing conduction in re-entrant pathways - Local anesthesia for pain control caused by infusion of fluids or medications via IO site
36
Acetaminophen trade name and class
- Tylenol, Ofirmev - Analgesic, Antipyretic
37
Acetaminophen MOA (2)
- Thought to act primarily in the CNS, increasing pain threshold by inhibiting isoforms of cyclooxygenase enzymes - Acts on heat-regulating centers of hypothalamus
38
Epinephrine class
Sympathomimetic
39
Adenosine trade name and class
- Adenocard - Endogenous nucleoside / misc. antidysrhythmic
40
Adenosine MOA (2)
- Slows conduction through the AV node - Most cases of PSVT involve AV nodal reentry, adenosine is capable of interrupting the AV nodal circuit and stopping the tachycardia, restoring normal sinus rhythm
41
Amiodarone trade name and class
- Cordarone - Class III antidysrhythmic
42
Amiodarone MOA (4)
- Multiple effects on sodium, potassium, and calcium channels - Prolongs action potential and repolarization - Decreases AV conduction and sinus node function - Also has some alpha and beta adrenergic blocking properties
43
Sodium Bicarbonate class
- buffer, alkalinizing agent, electrolyte supplement
44
Sodium Bicarbonate MOA (2)
- Reacts with hydrogen ions, forming water and CO2, correcting metabolic acidosis - Increases blood and urinary pH by releasing bicarbonate ion
45
Aspirin other names and class
- Acetylsalicylic Acid, ASA, Bayer, Ecotrin - Analgesic, Anti-platelet, anti-pyretic, anti-inflammatory
46
Aspirin MOA
- Inhibits prostaglandin and disrupts platelet function - Mild analgesic and anti-inflammatory
47
Fentanyl trade name and class
- Sublimaze - Opioid analgesic
48
Fentanyl MOA (3)
- Opioid agonist-analgesic - Inhibits ascending pain pathways, altering response to pain, increases pain threshold - Produces analgesia, respiratory depression, and sedation
49
Calcium chloride class
- Electrolyte
50
Calcium chloride MOA (5)
- Increases extracellular and intracellular Ca levels - Stimulates release of catecholamines - Increases cardiac contractile state (positive inotropic effectO) - Essential to transmission of nerve impulses, contraction of muscle - Has stabilizing effect on myocardial cell membranes in setting of hyperkalemia
51
Dopamine trade name and class
- Intropin - Sympathomimetic
52
Dopamine MOA (6)
- Endogenous catecholamine - Acts on both dopaminergic and adrenergic neurons - 1-2mcg/kg/min: dilates renal and mesenteric blood vessels, typically no effect on heart rate or BP - 2-10mcg/kg/min: beta effects on heart - 10-20mcg/kg/min: alpha peripheral effects resulting in increasing BP - 20-40mcg/kg/min: Increases HR and O2 demand to undesirable limits
53
Norepinephrine trade name and class
- Levophed - Sympathomimetic
54
Norepinephrine MOA (2)
- Catecholamine that stimulates beta-1 and alpha-1 receptors in sympathetic nervous system - Results in vasoconstriction, increased BP, enhanced contractility, and increased HR
55
Verapamil trade name and class
- Isoptin, Calan, Verelan - Calcium channel blocker (Class IV antidysrhythmic)
56
Verapamil MOA (4)
- Inhibits movement of Ca ions across cell membranes - Decreases atrial automaticity - Reduces AV conduction velocity - Depresses myocardial contractility, reduces vascular smooth muscle tone, dilates coronary arteries
57
Diltiazem trade name and class
- Cardizem - Ca channel blocker
58
Diltiazem MOA (3)
- Ca channel blocker - Inhibitory effects on cardiac conduction system, principally at AV node, slowing ventricular rate associated with Afib and Aflutter - Inhibition of contraction and dilation of coronary and systemic arteries
59

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