MOAs

Question 1

Ethanol

Answer 1

Increased: (GABA, 5-HT, beta-endorphin, CB1, DA), decreased NMDA

Question 2

Disulfiram

Answer 2

Inhibits aldehyde dehydrogenase

Question 3

Naltrexone

Answer 3

Mu opioid antagonist

Question 4

Acamprosate

Answer 4

GABAa agonist / NMDA antagonist

Question 5

Fomepizole

Answer 5

Inhibits alcohol dehydrogenase

Question 6

Benzodiazepines

Answer 6

Allosteric agonist for GABA receptor

Question 7

Buspirone

Answer 7

Something to do with serotonin

Question 8

Propranolol

Answer 8

Beta blocker

Question 9

TCAs

Answer 9

Decreased reuptake of NE and 5-HT

Question 10

Amoxapine

Answer 10

NE > 5-HT > DA reuptake inhibitor

Question 11

Maprotiline

Answer 11

Selective NE reuptake inhibitor

Question 12

Trazodone

Answer 12

5-HT modulator (+ a little SSRI)

Question 13

Nefazodone

Answer 13

5-HT modulator (+ a little SSRI)

Question 14

Mirtazepine

Answer 14

alpha2 antagonist –> increases release of 5-HT and NE

Question 15

Bupropion

Answer 15

Blocks reuptake of DA, 5-HT, and NE

Question 16

Venlafaxine

Answer 16

SNRI (zero antihistamine, anti-Ach, anti-NE effects)

Question 17

Duloxetine

Answer 17

SNRI (venlafaxine X100 potency)

Question 18

Vortioxetine

Answer 18

5-HT modulator (lots of different things)

Question 19

Vilazodone

Answer 19

5-HT modulator (+ a little SSRI)

Question 20

SSRIs

Answer 20

Inhibit reuptake of serotonin only

Question 21

MAOIs

Answer 21

Inhibit monoamine oxidase (increases lifespan of NE, 5-HT, tyramine, and DA

Question 22

Lithium

Answer 22

??? Interferes with IP3 signalling, neurotransmitter-mediated adenylate cyclase activity

Question 23

Valproate

Answer 23

Inhibits voltage gated Na channels, T-type Ca channels, GABA degredation. Stimulates K+ conductance, GABA synthesis

Question 24

Carbamazepine

Answer 24

Inhibits voltage-gated sodium channels

Question 25

Typical antipsychotics

Answer 25

D2 blockers

Question 26

Atypical antipsychotics

Answer 26

D2 blockers and 5-HT blockers

Question 27

Physostigmine

Answer 27

Cholinesterase inhibitor

Question 28

Bromocriptine

Answer 28

DA agonist

Question 29

St. John's Wort

Answer 29

Increased levels of DA and 5-HT in CNS

Question 30

Amphetamine

Answer 30

Increase release of NE and DA

Question 31

Atomoxitine

Answer 31

Blocks NE reuptake

Question 32

Dexmethylphenidate

Answer 32

DA and NE reuptake inhibitor

Question 33

Methylphenidate

Answer 33

DA and NE reuptake inhibitor

Question 34

Clonidine

Answer 34

alpha 2 agonist

Question 35

Gaunfacine

Answer 35

Post-synaptic alpha 2 agonist