mock questions Flashcards

1
Q

what is the gold standard investigations for kidney stones?

A

non-contrast CT KUB (kidney

ureter bladder)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

. A 28-year-old gentleman presents to A&E with severe 9/10 intermittent abdominal pain. The
pain woke him from sleep last night around midnight and is felt on his right side as well as in
his testicles. When he went to the toilet he also noticed his urine was red. He is a non-smoker
and on observations he does not have a fever.

A

kidney stones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what defines CKD?

A
  • eGFR <60mls/min/1.73m2 >3 months
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what defines end stage renal failure?

A

eGFR <15

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is a potential side effect of tamsulosin?

A

postural hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

why might tamsulosin be perscribed?

A

for benign prostate hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the commonest type of renal cell carcinoma?

A

clear cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Robert, a 76-year-old gentleman, presents to his GP with urinary frequency, haematuria and
night sweats. He also reports 2 stone recent weight loss. DRE reveals hard craggy mass.

A

prostate cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what class of drug is goserelin?

A

GnRH agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what class of drug is tamsulosin?

A

alpha blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the risk factors for erectile dysfunction?

A

Psychological causes include stress, depression and poor relationship with partner. Physical
causes include cardiovascular disease, diabetes, trauma. Lifestyle causes include smoking,
alcohol, obesity. Radical prostatectomy is a common cause.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

where / why is erythropoietin secreted?

A

in the kidneys, due to low RBC count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what complicates a UTI?

A

male, pregnancy, children under 2 months old, immunocompromised, recurrent UTIs, structural abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how might autosomal dominant polycystic kidney disease cause a SAH?

A

causes a berry aneurysm, ruptures causing a SAH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the gold standard investigation for renal colic?

A

Non-contrast CT kidney, ureter, bladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the most common composition of renal stones?

A

calcium oxalate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

why might a renal stone be made of ammonium phophate?

A

occurs in renal colic caused by proteus, klebsiella and

pseudomonas bacterial infections causing ammonia build-up in the urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is the second most common composition of renal stones?

A

calcium phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

why might a renal stone be made up of cystine?

A

rare and tend to occur in people who have rare genetic disorders that cause
cystine to leak from the kidneys into the urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

. A 45-year-old painter presents to the GP with blood in his urine. He says he has the urge to
go to the bathroom more been going to the bathroom more often than normal and there
isn’t any pain when he goes. He states he has noticed he has lost some weight over the
last few weeks without trying to, but he has been quite happy about that. What is the
most likely diagnosis?

A

bladder cancer - Painless haematuria is a strong suggestion of bladder cancer especially with changes to their bladder
habits. The patient is a painter also suggests this as exposure to azo dyes is a risk factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what might someone with BPH present with?

A

nocturia
poor stream
post-micturition dribbling
urgency incontinence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what are some common bacterial causes of UTIs?

A
e.coli
proteus mirabilis
klebsiella pneumoniae
staphlococcus saprophticus 
enterococcus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how is nephrotic syndrome defined?

A

Proteinuria (>3.5g/day) – damaged glomerulus more permeable → more protein come across
from blood into nephron → proteinuria
• Hypoalbuminaemia – albumin leaves blood
• Oedema (periorbital and arms) – oncotic pressure falls due to less protein in blood → lower
osmotic pressure → water driven out of vessels into tissues
• Hyperlipidaemia and lipiduria – loss of protein = less lipid synthesis → more lipids in blood →
more in urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what component of U&Es should we be most concerned about in a patient with AKI?

A

potassium - When a patient with an AKI’s kidney function start failing, they are unable to excrete potassium.
When this happens, it causes a build-up in the blood and leads to hyperkalaemia which is a medical
emergency as it can result in a cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
what the GFR in stage 1 CKD?
> 90 ml/min with evidence of renal damage
26
what is the GFR in stage 2 CKD?
60-89 ml/min with evidence of renal damage
27
what is the GFR in stage 3a CKD?
45-59 ml/min with or without renal damage
28
what is the GFR in stage 3b CKD?
30-44 ml/min with or without renal damage
29
what is the GFR in stage 4 CKD?
15-29 ml/min with or without renal damage
30
what is the GFR in stage 5 CKD?
<15 ml/min, established renal failure
31
what is furosemide?
a loop diuretic which acts on the ascending limb of the loop of Henle and inhibits the NKCC2 channels
32
what is spironolactone or amiloride?
potassium sparing diuretic and they typically act on the distal convoluted tubule
33
what is bendrodflumathiazide?
a thiazide which acts on the | sodium/chloride transporters and prevents them from functioning properly
34
what is the most common cause of AKI?
acute tubular necrosis - tubular epithelial cells of the kidneys die impairing the kidneys ability to filter waste products, intrarenal cause
35
is hyper or hypovolaemia more likely to cause AKI?
hypovolaemia
36
how can nephrotoxins cause AKI?
intrinsic or renal AKI; the kidneys are directly damaged impairing their ability to function
37
what are risk factors for CKD?
diabetes, CKD family history, old age, recurrent UTIs
38
what is the most common cause of pylonephritis?
e.coli from bowel flora
39
what can cause pylonephritis?
``` ecoli (most common) staphlococcus saprophyticus enterococcus klebisella proteus ```
40
what is the best investigation for the management of pylonephritis?
Midstream urine microscopy, culture and sensitivity
41
Alex, a 45-year-old builder presents to your GP with a 7-month history of recurring perineal pain as well as pain and difficulty when passing urine. He says he needs to go to the toilet many times a day which is starting to affect his work. On further questioning he reluctantly tells you that he has also had some pain when ejaculating. Alex mentions a workplace incident that he thinks might be related, where he fell from height and injured his hip close to a year ago. You decide to carry out a digital rectal exam- you don’t think his prostate is hard or irregular. What is the most likely diagnosis based on the history so far?
prostatis - Chronic prostatitis is characterised by pelvic or perineal pain lasting longer than 3 months as the key symptom. Also trauma causing nerve damage in the lower urinary tract is a risk factor for chronic prostatitis
42
. Lucy is a 30-year-old woman who is 2 months pregnant, as her GP you find that she has a lower urinary tract infection and are considering which antibiotic to prescribe her. Which of the following medications would you definitely avoid prescribing?
trimethoprim - teratogenic risk in the first trimester as it inhibits folate synthesis.
43
James is a 25-year-old male who recently tested positive for Chlamydia, he went to get tested after he noticed pain on urinating and discharge from his penis. He is now quite concerned as his eyes have turned red and his ankles and feet have become swollen. What can be used to describe his symptoms?
reiter's syndrome - also known as reactive arthritis, is the classic triad of conjunctivitis, urethritis, and arthritis occurring after an infection
44
. Ray, a 32-year-old gentleman with heterozygous polycystic kidney disease (PKD) presents to the genetic counselling clinic. He informs you that his wife, who does not suffer from PKD, is pregnant and that they are expecting their first child in 3 months time. What is the likelihood that their newborn child will also have PKD?
50% - autosomal dominant inheritance
45
what are the complications of PKD?
CVD, kidney stones, polycystic liver disease, SAH
46
what testicular cancer secretes ALP?
testicular seminoma
47
how do uric acid stones appear on x-rays?
radiolucent (transparent)
48
what is a prognostically beneficial drug for prostate cancer?
finasteride = inhibits testosterone to dihydrotestosterone (prognostic benefit to prostate cancer)
49
at what age are children no longer classed as complicated UTIs?
over 2 months old
50
what treatment would you give someone who has had one attack of gout and is asking for prophylaxis?
give lifestyle advice
51
what treatment would you give as prophylaxis to someone who has had 2 attacks of gout?
allopurinol and Colchicine (as gout is more common at start of treatment so need this too), after 2 weeks, stop colchicine
52
how would you treat hypercalcaemia?
fluids, bisphosphonates, calcitonin
53
what would be a secondary differential for UTI symptoms with suprapubic pain?
cystitis - bladder
54
what are risk factors for UTI?
female, post menopausal, DM, catheter
55
what is the gold standard investigation for transitional cell carcinoma?
cystoscopy
56
what is goodpasture's syndrome?
type II hypersensitivity reaction, positive against anti-glomerular basement membrane antibodies. Affects type IV collagen which is found both in the lung alveoli and the glomerulus. Biopsy finds deposits of IgA and IgG. The haemoptysis and haematuria can cause anaemia. Nephritic syndromes are characterised by haematuria, hypertension, proteinuria, oliguria, and uraemia. Can be pANCA positive
57
A 45-year-old man was seen by his GP when he started coughing and found small amounts of blood in his sputum. On taking a history it was found that the patient had not been urinating very much in a day. The GP decides to get a chest x-ray, take some bloods and do a urine dip. The results are: • CXR – interstitial pneumonia with patchy alveolar infiltrates – suggestive of bleeding sites. • Urine dipstick – positive for blood and protein, negative to nitrates. • Bloods – cANCA negative, pANCA positive, haemoglobin low, anti-Glomerular basement membrane Antibodies positive, urea high, eosinophils normal What is the most likely diagnosis?
good pasture's syndrome
58
how is chlamydia treated?
doxycycline or azithromycin
59
how is gonorrhoeae treated?
azithromycin and ceftriaxone
60
what does ANCA positive mean?
autoimmune vasculitis
61
what would IgA nephropathy that is ANCA positive indicate?
vasculitis / Pauci-immune necrotising glomerulonephritis
62
how are ANCA positive patients treated?
corticosteroids and rituximab
63
where are the 3 most common places for renal stone formation?
Pelviureteric junction/ureteropelvic junction – where the renal pelvis connects to the ureter Pelvic brim – where the ureter crosses over the pelvic brim and the bifurcation of the common iliac arteries Vesicoureteric junction/ureterovesicular junction – where the ureter connects to the urinary bladde
64
what are the risk factors for renal stone formation?
dehydration, infection, hypercalcaemia, hyperoxaluria, hypercalciuria, hyperuricaemia, primary renal disease, drugs: diuretics, antacids, corticosteroids, aspirin, allopurinol, vitamin c, vitamin d; diet: chocolate, tea, strawberries, rhubarb; gout, family history, anatomic abnormalities that predispose to stone formation
65
how would someone reduced the likelihood of them getting renal stones?
maintain hydration, low calcium intake in the diet e.g. reduce levels of dairy, green leafy veg, fish where you eat the bone e.g. sardines and food with fortified flour , low salt diet e.g. reduce the levels of processed meat, ready meals, reduce animal protein intake, reduce BMI, be active/exercise
66
what is the triad of symptoms for pyelonephritis?
loin pain, fever, polyuria
67
what is the diagnostic test for pyelonephritis?
midstream urine sample with microscopy, culture and sensitivity
68
what type of bacteria is neisseria gonnorrhoea?
gram negative diplococci
69
what is henoch-schonlein purpura?
triad of rash, abdominal pain, arthritis/arthralgia and glomerulonephritis. It is more common in males aged 3-15 and occurs after at URTI
70
what collagen does alport's syndrome affect?
IV
71
what is the first line treatment of pylonephritis?
cephalexin
72
what is the second most common cause of renal stones?
magnesium ammonia phosphate
73
what is prehn's sign?
pain relived when lifting the scrotum, indicates epididymytis
74
what is the first line treatment of diabetic nephropathy?
ACEi
75
where does the left testicular vein drain into?
left renal vein
76
what is silenafil?
viagra - 5-alpha-reductase inhibitor
77
what parasite can cause bladder cancer?
Schistosomiasis
78
what is the triad of symptoms for renal cell carcinoma?
haematuria, flank pain, palpable mass
79
what can cause intrarenal CKD?
Glomerulonephritis / PKD / Drugs e.g NSAIDS/Lithium
80
what is the definition of erectile dysfunction?
Inability to maintain an erect penis long enough to achieve sexual satisfaction
81
what are the storage symptoms of a UTI?
Frequency, Urgency, Nocturia, Incontinence
82
what are the voiding symptoms of a UTI?
Poor stream, Hesitancy, Straining, Incomplete emptying, Terminal dribble
83
how is stress incontinance managed?
Non-Pharmacological: Pelvic Floor Exercises Pharacological: Duloxetine Surgical : Sling / Colposuspension / Artificial urinary sphincter
84
what race is at a higher risk of developing prostate cancer?
afro-carribean
85
what is the name of the pathogen causing chlamydia?
Chlamydia Trachomatis
86
how is syphalis treated?
azithromycin
87
what can kidney stones be composed of?
calcium, uric acid, cholestrol, stiruvate
88
what is the radiological treatment for kidney stones?
Ultrasound shock wave therapy or ultrasound shock wave lithotripsy