Modes of action of antidepressant drugs Flashcards
(21 cards)
Agomelatine
- 5-HT2C antagonist- ends up acting as a norepinephrine and dopamine disinhibitor
- melatonin (MT2 and MT2) agonist
Amoxapine
- tetracyclic and dibenzoxazepine structure
- dopamine antagonist
- serotonin-noradrenaline reuptake inhibition
Bupropion
- dopamine and noradrenaline reuptake inhibitor
- used to help with quiting smoking and in depression
- competitive nicotinic antagonist
Busipirone
-partial agonist on serotonin 5-HT1A receptors
Citalopram
- SSRI
- most selective for serontonin
Clomipramine
- TCA-most potent
- high SRI selectivity but not as much as SSRIs
Desimipramine
-TCA with least anticholinergic action but lethal on overdose
Duloxetine
-SNRI
Lithium
- acts via the seond messenger system
- enhances serotonin transmission by enhanving release, increasing tryptophan uptake, downregulation of 5-HT1A, 1B and 2 receptor subtypes
- directly inhibits glycogen synthase kinase 3
Milnacipran
-SNRI similar to venlafaxine
Mirtazapine
-5-HT2A antagonism
-alpha 2 antagonism
-anti-histaminic and anti 5-HT3 properties
NASSA
Moclobemide
-reversible inhibitor of MAO-A selectively
Paroxetine
- SSRI
- most potent in serotonin reuptake blockade but not specific- has antimuscarinic action
Phenelzine
-MAOI
Pindolol
- beta-blocker with sympathomimetic activity
- also 5-HT1A antagonism- may enhance onset of action of SSRIs
Reboxetine
Noradrenergic specific reuptake inhibitor (NARI)
Selegiline
MAOi
-Selective for B but not in patch form
Tranylcypromine
MAOi
-irreversible, non-selective
Trazodone
5-HT2A/2C antagonist and some alpha 2 blockade
- Serotonin antagonist and reuptake inhibitor (SARI)
- feeble reuptake inhibition at serotonin transporters
Venlafaxine
SNRI -serotnin noradrenaline reuptake inhibitor
-acts as an SSRI at lower doses
Vortioxetine
-similar to reboxetine
predominantly SSRI
-also shows 5-HT3 antagonism and 5-HT1A agonism
