Module 1 - Cardiovascular System Flashcards
(43 cards)
How do cells respond to stress?
Cells respond to stress by using reserves to continue functioning or adapting through changes.
What does a cell do in response to stress? (5 concepts)
Atrophy, Hypertrophy, Hyperplasia, Metaplasia, Dysplasia
Describe Atrophy
Reversible reduction in size due to disuse or malnutrition
E.g. When a muscle is not used it atrophies and reduces in size
Describe Hypertrophy
Size Increase due to increased workload
E.g. A muscle is stressed so increases in size to better manage stress
Describe Hyperplasia
Cell numbers increase due to such things as hormonal stimulation
E.g. Increase in breast size during pregnancy
Describe Metaplasia
Cell Type Replacement to better endure stress
What is dysplasia?
Abnormal changes in size, shape and appearance of a cell. Potentially reversible but can also precede cancer
What is cell degeneration?
Non-lethal damage. Generally affected the cytoplasm. Can be caused by various factors (swelling, fatty infiltrates, and atrophy). Affecting organs with active cells like the liver, heart, and kidneys. Prompt treatment can slow cell degeneration.
What is Toxic Injury? Including Endogenous and Exogenous Factors
Toxic injury is a type of injury due to exposure to a toxin. It is caused by endogenous factors like metabolic errors or exogenous factors like drugs or alcohol
What is Infectious Injury?
An injury caused by bacteria or other pathogens that disrupt cell synthesis
What is Physical Injury?
A type of injury resulting from thermal (e.g. radiation, atmospheric pressure) or mechanical (e.g. trauma, extreme temperatures) disruptions
Describe Dysplasia
Abnormal Growth
What is deficit injury?
Deficit injury occurs when there is a deficit of necessary substances. Such as water, oxygen, nutrients, temperature regulation, waste disposal, leading to cell disruption or necrosis
What are the 4 components of blood?
55% plasma (mostly water, and essential protiens)
Erythrocytes
Leukocytes
Platelets
What are the layers of the pericardium sac?
Epicardium - outer protective layer
Myocardium - muscular middle layer
Endocardium - thin inner layer
What are the chambers of the heart and in which order does blood flow through them?
Right atrium (1st), Right Ventricle (2nd), Left Atrium (3rd), Left Ventricle (4th)
What are the 4 Valves of the heart and where are they located and finally their function?
Tricuspid Valve - located between the right atrium and right ventricle
Pulmonary Valve - located between the right ventricle and pulmonary valve
Mitral Valve - located between the left atrium and left ventricle
Aortic Valve - located between left ventricle and aorta
All the valves prvent backflow of blood
List the flow order of the heart
Superior Vena Cava
Inferior Vena Cava
Right Atrium
Tricuspid Valve
Right Ventricle
Pulmonary Valve
Pulmonary Artery
Pulmonary Veins
Left Atrium
Mitral Valve
Left Ventricle
Aortic Valve
Aorta
What are the 3 types of circulation?
Pulmonary - circulation that moves blood from the right ventricle to the lungs and back to the left ventricle
Systemic - circulation that delivers oxygenated blood from the left ventricle to the body, returning deoxygenated blood to the right atrium
Coronary - circulation that supplies the heart with oxygenated blood and removes deoxygenated blood
What is a haemodynamic disorder?
A condition affecting the dynamics of blood circulation within the body, including blood flow patterns, pressures or volumes
What is oedema? Describe the pathophysiology, aetiology, clinical manifestations, diagnosis and management
A haemodynamic disorder resulting from an imbalance in starling forces, that being capillary hydrostatic pressure, interstitial hydrostatic pressure, capillary oncotic pressure and interstitial oncotic pressure.
Aetiology includes high blood pressure, chemical mediators in injury, excessive fluid intake causing overload or water intoxications, and lymphatic system obstructions.
Manifestations include weight gain, swelling or puffiness both localised and systemic, in extreme cases threatening life, especially of vital organs.
Diagnosis through X-ray, medical history, physical exams and blood analysis
Management is heavily dependent on location but involves compression, elevation if in limbs or special management for brain, lung and other organ affecting oedema. Diuretics to reduce fluid content. Finally reducing sodium intake in diet.
What is hypertension? Describe the pathophysiology, aetiology, clinical manifestations, diagnosis and management
A haemodynamic disorder in which blood pressure is elevated outside of normal ranges, typically 140/90mmHg or higher. Note that normal blood pressure varies from person to person due to environmental factors.
Essential hypertension has no identifiable cause. However, Secondary hypertension results from other conditions such as lifestyle factors, high cholesterol, and diabetes.
In extreme cases can cause, blurred vision, chest pain and other similar symptoms.
Because it is typically asymptomatic. It is often diagnosed unintentionally during blood pressure assessment such as during checkups or when being assessed for other reasons.
Management includes lifestyle changes, ACE inhibitors (relaxes blood vessels), Angiotensin 2 receptor blockers (relax blood vessels), Calcium channel blockers (relax blood vessels), Diuretics (reduce water content, therefore blood pressure)
What is Circulatory Shock? Describe the pathophysiology, aetiology, clinical manifestations, diagnosis and management
A haemodynamic disorder that occurs when the body is not getting enough blood flow, thus depriving its cells of nutrients and is life-threatening. The effects of shock are reversible in early stages, a delay in diagnosis and/or timely initiation of treatment can lead to irreversible changes including multiorgan failure and death.
Most often caused by a serious heart attack, but can also be due to heart failure, a serious chest injury, and blood clots in the lungs.
Symptoms include rapid breathing, severe shortness of breath, sudden rapid heartbeat (tachycardia), loss of consciousness, weak pulse, low blood pressure (hypotension), sweating and pale skin.
Diagnosed through assessment of heart and lung sounds and rhythm. How much you urinate is an indicator of kidney function. Blood pressure assessment which on its own can be used to diagnose circulatory shock.
Management includes oxygen supplementation through a nasal tube or mask, breathing assistance via a ventilator, and intravenous fluids. Blood pressure and heart medications, ACE inhibitors, angiotensin 2 receptor blockers, calcium channel blockers, and diuretics.
What is vascular disorder? Describe the pathophysiology, aetiology, clinical manifestations, diagnosis and management
A haemodynamic disease affecting blood vessels that carry oxygen and nutrients throughout the body and remove waste from your tissues.
Vascular problems often occur because of fat and cholesterol buildup in blood vessels. This slows or blocks blood flow inside your arteries or veins.
Symptoms include wounds that won’t heal over pressure points, such as heels or ankles. Numbness, weakness or heaviness in muscles. Burning or aching pain at rest commonly in the toes and at night while lying flat. Restricted mobility, thickened, opaque toenails, varicose veins.
Treatment and management include lifestyle changes such as eating a heart-healthy diet and getting more exercise. Medicines such as blood pressure medicines, blood thinners, cholesterol medicines, and clot-dissolving drugs. Non-surgical procedures, such as angioplasty, stenting, and vein ablation. Surgery.