Module 1 Volume 2 Chapter 1 Pathopysilogy Flashcards

Integrate comprehensive knowledge of pathophysiology of major human systems (375 cards)

1
Q

ABO Blood Groups p. 92

A

Four Blood groups formed by the presence or absence of 2 antigens known as Aand B. A person may have either (type A or type B), both (type AB) or neither (type O). An immuneresponse will be activated whenever a person receices blood containing A or B antigen if this antigen is not already present in his own blood

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2
Q

Acid-Base reaction p 25

A

any chemical reaction that results in the transfer of protons

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3
Q

Acidosis p 28

A

a high concentration of hydrogen ions; a pH below 7.35; an excess of acids in the body.

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4
Q

Acids p. 25

A

substances that give up protons during chemical reactions

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5
Q

Adenosine Triphosphate (ATP)

A

a high energy compound present in all cells, epsecially muscle cells when splid by enzyme action, it yields energy. energy is stored in ATP

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6
Q

Adipocytes p 63

A

fat cells

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7
Q

Adipose tissue

A

fat

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8
Q

Aerobic metabolism

A

the 2nd stage of metabolism, requiring the presence of oxygen, in which the breakdown of glucose (in a process called the Krebs or citric acid cycle) yields a high amount of energy. Aerobic means ‘with oxygen’

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9
Q

afterload p 73

A

the resistance a contraction of the heart mus overcome in order to eject blood; in cardiac physiology, defined as the tension of cardiac muscle during systole (contraction)

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10
Q

AIDS p 111

A

Aquired immunodeficiency syndrome: a group of signs symptoms and disorders that often develop as a consequence of HIV infection

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11
Q

albumin p45

A

a protein commonly present in plant and animal tissues. in the blood, albumin works to maintain blood volume and blood pressure and provides colloid osmotic pressure which prevents plasma loss from the capillaries

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12
Q

alkalosis p28

A

a low concentration of hydrogen ions; a pH above 7.45; an excess of base in the body.

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13
Q

allergy p 107

A

exaggerated immune response to an environmental antigen

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14
Q

amino acids p18

A

molecules containing an amine group, a carboxylic acid groups, and varying side chains

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15
Q

amylopectin p 17

A

a highly branched polymer of glucose; one of two types of starch, the other being amylose

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16
Q

amylose p 17

A

a linear, unbranched polymer of glycose;one of two types of starch, the other being amylopectin

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17
Q

anabolism p23

A

the constructive phase of metabolizm, which cells convert nonliving substances into living cytoplasm; the synthesis of steroid compounds by the body

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18
Q

anaerobic metabolism p. 76

A

the first stage of metabolism, which does not require oxygen in which the breakdown of glucose (in aprocess called glycolysis) produces pyruvic acid and yields very little energy. Anaerobic means ‘without oxygen’

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19
Q

anaphylaxis p.82

A

a life-threatening allergic reaction; also called anaphylactic shock

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20
Q

anencephaly p.8

A

a birth defect in which a baby is born without parts of the brain and skull

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21
Q

anion p14

A

an ion with a negative charge-so called because it will be attracted to an anode or positive pole

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22
Q

antibiotics p86

A

agent that kills or decreases the grouth of bacteria

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23
Q

antibodies p88

A

a substance produced by B lymphocytes in response to the presence of a foreign antigen that will combine with and control or destroy the antigen thus preventing infection

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24
Q

antigens p.88

A

a marker on the surface of a cell that indetifies it as ‘self’ or non-self

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25
antigen-antibody complexes p.93
the substance formed when an antibody combines with an antigen to deactivate or destroy it; also called immune complex
26
antigen-presenting cells APCs p97
cells, such as macrophages, that present (express onto their surfaces) portions of the antigens they have digested
27
antigen processing p.96
1the recognition, ingestion and breakdown of a foreign antigen culminating in production of an antibody to the antigen or in a direct cytotoxic response to the antigen
28
Apoptosis
response in which an injured cell releases enzymes that engulf and destroy intself; one way the body rids itself of damaged and dead cells.
29
atom p.12
the fundamental chemical unit which contains subatomic particles including electrons protons and neutrons.
30
atomic number p12
the number of protons in the nucleus of an atom; an element is defined by its atomic number
31
atrophy p56
a decrease in cell size resulting from a decreased workload
32
autoimmune disease p9
failure of the immune system to recognize certain tissues normally present in the body resulting in an attack against those tissues by the immune system; autoimmune disease includes rheumatic heart disease and rheumatoid arthritis
33
autoimmunity p107
an immune response to self-antigens which the body normally tolerates.
34
B lymphocytes p89
the type of white blood cells that in response to the presence of an antigen produce antibodies that attack the antigen develop a memory for the antigen and confer long term immunity to the antigen
35
bacteria p.86
(singular bacterium) single-cell organisms with a cell membrane and cytoplasm but no organized nucleus. they bind to the cells of a host organism to obtain food and support
36
Basement Membrane p.61
a thin sheet of fibers that underlies the epithelia, the membranes that line or cover internal and external body surfaces
37
Bases p.25
substances that acquire protons during chemical reactions
38
Basophils p104
granular white blood cells that similarly to mast cells release histamine and other chemicals that control constriction and dilation of blood vessels during inflammation
39
benign p10
not cancerous; not able to spread to other tissues
40
buffer p27
a substance that tends to preserve or restore a normal acid-base balance by increasing or decreasing the concentration of hydrogen ions
41
Carcinogenesis p.68
a process of developing a cancer
42
carinoma-in-situ p.58
an early form of cancer in which tumor cells have not yet invaded surrounding tissues
43
cardiac contractile force p.73
the strength of a contraction of the heart
44
cardiac output
the amount of blood pumped by the heart in 1 minute (computed as stroke volume x heart rate)
45
cardiogenic shock
shock caused by insufficient cardiac output; the inabilitity of the heart to pump enough blood to perfuse all parts of the body
46
carrier proteins
proteins involved in carrying solutes (ions or molecules) across a biologic membrane
47
cartilage
a type of connective tissue that provides structure and support to other tissues
48
cascade
a series of actions triggered by a first action and culminating in a final action--typical of the actions caused by plasma proteins involved in the complement coagulation and kinin systems.
49
catabolism
the destructive phase of metabolism in which cells break down complex substances into simpler substances with release of energy
50
catecholamines
epinephrine and norepinephrine hormones that stongly affect the nervous and cardiovascular systems metabolic rate temperature and smooth muscle
51
cation
an ion with a positive charge so called because it will be attracted to a cathode or negative pole.
52
cell
the basic structural unit of all plants and animals. a membrane enclosing a thick fluid and nucleus. cells are specialized to carry out all of the body's basic functions
53
cell-mediated immunity
the short term immunity to an antigen provided by T lymphocytes wich directly attack the antigen but do not produce antibodies or memory for the antigen
54
cell membrane
also plasma membrane; the outer covering of a cell
55
cellular adaptation
physiologic or structural changes to a cell in response to change or stress or a pathological condition
56
cellular respiration
metabolic processes with a cell that convert nutrients to energy in the form of adenosine triphosphate and that subsequently release waste products from the cell
57
cellulose
a polysaccharide polymer with glucose as its monomer that is the major strucural material of plants
58
centrioles
cylindrical structures within cells that play important role in cell division
59
chemoreceptors
sensory receptors that detect and act on chemical signals--for example, sensing a change in carbon dioxide levels in the blood and responding by causing an increase in respiratory rate to expel the excess carbon dioxide from the body
60
chemotactic factors
chemicals that attract white cells to the site of inflammation a process called chemotaxis
61
chemotaxis
attracting white cells to the site of inflammation
62
chromatin
a combination of DNA and other proteins in the nucleus of a cell that condenses to form chromasomes
63
chromosomes
threadlike structures within the nuclei of cells that carry genetic information
64
chronic
slow in the onset persisting over a long period of time as in a chronic disease
65
cilia
threadlike projections from the surface of cells that move back and forth and can sweep debris such as mucus or dust away from the cell
66
cisternae
saclike structures within the body cells that form part of the structure of rough endoplasmic reticulum and the golgi apparatus an act as carrier vessels that transport proteins from the RER ro the Golgi apparatus for furthur processing
67
citric acid cycle
a key phase of glucose metabolism requiring the presence of oxygen in which pyruvic acid a product of the breakdown of glucose is oxidized resulting in the release of energy in the form of ATP and carbon dioxide as waste. Also called kreps cycle or the tricarboxylic acid cycle
68
clinical presentation
The manifestation of a disease; the signs and symptoms of a disease
69
clonal diversity
the development of receptors, by Blymphocyte precursors in the bone marrow, for every possible type of antigen
70
clonal selection
the process by which a specific antigen reacts with the appropriate receptors on the surface of immature B lymphocytes therby activating them and prompting them to proliferate differentiate and produce antibodies to the activating antigen
71
coagulation system
a plasma protein system that results in formation of a protein called fibrin. Fibrin forms a network that walls off an infection and forms a clot that stops bleeding and serves as a foundation for repair and healing of a wound.
72
coenzymes
non protein substances that bind to enzyme proteins to assist them in biochemical transformations.
73
cofactors
see coenzymes
74
collagen
proteins that are the main component of connective tissue
75
colloid
intravenous solutions containing large proteins that cannot pass through capillary membranes
76
compensated shock
early stage of shock during which the body's compensatory mechanisms are able to maintain normal perfusions
77
complement system
a group of plasma proteins (the complement proteins) that are dormant in the blood until activated as by antigen-antibody complex formation by products released by bacteria or by components of other plasma protein systems. when activated, the complement system is involved in most of the events of inflammatory response
78
complications
abnormalities or conditions that result from another orginal disease or problem
79
compound
chemical union of two or more elements
80
concentration gradient
the gradual change in concentration of a solution over a distance within the solution
81
congenital metabolic disease
diseases affecting the metabolism that are present from birth
82
connective tissues
the most abundant body tissue it provides support connection and insulation examples bone cartilage fat blood
83
contraction
inward movement of wound edges during healing that eventually brings the wound edges together
84
cortisol
a steroid hormone released by the adrenal cortex that regulates the metabolism of fats, carbohydrates, sodium, potassium and proteins and also has an anti-inflammatory effect
85
covalent bond
force holding atoms together that results when atoms share electrons
86
cristae
folds within mutochondria that form shelves within the mitochondria
87
crystalloids
intravenous solution that contains electrolytes but lacks the larger proteins associated with a colloid
88
cytokines
proteins produced by white blood cells that regulate immune responses by binding with and affecting the function of the cells that produced them or of other nearby cells
89
cytoplasm
1
90
cytoskeleton
1
91
cytotoxic
1
92
debridement
1
93
decompensated shock
1
94
degranulation
1
95
dehydration
1
96
delayed hypersensitivity reactions
1
97
denaturation
1
98
deoxyribonucleic acid (DNA)
1
99
Diagnosis
1
100
diapedesis
1
101
disaccharides
1
102
disease
1
103
dissociate
1
104
Dissociation Reaction
1
105
dynamic steady state
1
106
dysplasia
1
107
dysplastic
1
108
ectoderm
1
109
edema
1
110
electrolyte
1
111
electrons
1
112
electron shells
1
113
electron transport chain
1
114
element
1
115
endocrine secretions
1
116
endocytosis
1
117
endoderm
1
118
endoplasmic reticulum
1
119
endotoxins
1
120
enzymes
1
121
enzyme-substrate complex
1
122
eosinophils
1
123
epithelial tissue
1
124
epithealialization
1
125
epithelium
1
126
erythrocytes
1
127
etiology
1
128
eukaryotic cells
1
129
exocrine secretions
1
130
exocytosis
1
131
exotoxins
1
132
extracellular fluid ECF
1
133
exudate
1
134
facilitated diffusion
1
135
fermentation
1
136
fibroblasts
1
137
fick principle
1
138
filtration
1
139
flagella
1
140
free radicals
1
141
free water
1
142
fructose
1
143
galactose
1
144
general adaptation syndrome GAS
1
145
germ layers
1
146
glucose
1
147
glycogen
1
148
glycogenolysis
1
149
glycolysis
1
150
golgi apparatus
1
151
granulation
1
152
granulocytes
1
153
granuloma
1
154
half-life
0
155
haptens
0
156
hematocrit
0
157
hemoglobin
00
158
histamine
0
159
histology
0
160
histopathology
0
161
HIV
0
162
HLA antigens
00
163
homeostasis
0
164
humoral immunity
0
165
hydrogen bond
0
166
hydrophilic
0
167
hydrophobic
0
168
hydrostatic pressure
0
169
hypercapnia
00
170
hyperplasia
00
171
hypersensitivity
0
172
hypertonic
0
173
hypertrophy
0
174
hyperventilation
0
175
hyperventilation syndrome
0
176
hypocapnia
0
177
hypoperfusion
0
178
hypotonic
0
179
hypoventilation
0
180
hypovolemic shock
0
181
hypoxemia
0
182
hypoxia
0
183
iatrogenic disease
0
184
idiopathic
0
185
immediate hypersensitivity reactions
0
186
immune response
0
187
immunity
0
188
immunogens
0
189
immunoglobulins
0
190
inflammation
0
191
inorganic chemicals
0
192
insidious
0
193
interstitial fluid
0
194
intracellular fluid
0
195
intravascular fluid
0
196
ion
0
197
ion channels
0
198
ionic bonds
0
199
irreversible shock
0
200
ischemia
0
201
isoimmunity
0
202
isotonic
0
203
isotopes
0
204
kinin system
0
205
lactose
0
206
leukocytes
0
207
leukotrienes
0
208
lipidbilayer
0
209
lipids
0
210
logarithm
0
211
lymphocyte
0
212
lymphokine
0
213
lysosomes
0
214
macrophages
0
215
major histocompatability complex
0
216
malignant
0
217
maltose
0
218
margination
0
219
mass number
0
220
mast cells
0
221
maturation
0
222
memory cells
0
223
mesoderm
0
224
metabolic acid-base disorders
0
225
metabolic acidosis
0
226
metabolic alkalosis
0
227
metabolism
0
228
metallic elements
0
229
meaplasia
0
230
metastasis
0
231
milliequivalents
0
232
minute volume
0
233
mitochondria
0
234
molarity
0
235
mole
0
236
molecule
0
237
monoclonal antibody
0
238
monocytes
0
239
monokine
0
240
monomer
0
241
monosaccharides
0
242
multiple organ dysfunction syndrome (MODS)
0
243
muscle tissues
0
244
natriuretic peptides (NPs)
0
245
Natural immunity
0
246
necrosis
0
247
negative feedback loops
0
248
neoplasia
0
249
neoplasm
0
250
nerve tissues
0
251
net filtration
0
252
neurogenic shock
0
253
neuroglia
0
254
neurons
0
255
neutrons
0
256
neutrophils
0
257
noble gases
0
258
nonmetallic elements
0
259
nuclear envelopes
0
260
nuclear pores
0
261
nucleolus
0
262
nucleoplasm
0
263
nucleotides
0
264
nucleus
0
265
oncotic force
0
266
orbital
0
267
organ
0
268
organ systems
0
269
organelles
0
270
organic chemicals
0
271
organisms
0
272
osmolality
0
273
osmolarity
0
274
osmosis
0
275
osmotic diuresis
0
276
osmotic gradient
0
277
osmotic pressure
0
278
osteocytes
0
279
overhydration
0
280
oxidation
0
281
PaCO2
0
282
Pathogenesis
0
283
Pathologist
0
284
pathology
0
285
pathophysiology
0
286
peptide
0
287
peptide bonds
0
288
perfusion
0
289
peroxisomes
0
290
peripheral vascular resistance
0
291
pHscale
0
292
phagocytes
0
293
phagocytosis
0
294
phospholipids
0
295
physiologic stress
0
296
pinocytosis
0
297
plasma
0
298
plasma membrane
0
299
plasma protein systems
0
300
platelets
0
301
pOH scale
0
302
polar bonds
0
303
polar molecules
0
304
polymer
0
305
polypeptide
0
306
polysaccharides
0
307
predisposing factors
0
308
preload
0
309
primary immune response
0
310
primary intention
0
311
prognosis
0
312
prokaryotic cells
0
313
prostaglandins
0
314
proteins
0
315
protons
0
316
psychoneuroimmunological regulation
0
317
pus
0
318
readioactive decay
0
319
radioactive isotopes
0
320
reduction
0
321
regeneration
0
322
repair
0
323
resolution
0
324
respiratory acid-base disorders
0
325
respiratory acidosis
0
326
respiratory alkalosis
0
327
Rh blood group
0
328
Rh factor
0
329
ribunucleic acid RNA
0
330
ribosomes
0
331
rough endoplasmic reticulum (RER)
0
332
Saturated fatty acids
0
333
secondary immune system
0
334
semipermeable
0
335
septic shock
0
336
septicemia
0
337
sequelae
0
338
serotonin
0
339
shock
0
340
sign
0
341
simple diffusion
0
342
smooth endoplasmic reticulum (SER)
0
343
sodium-potassium pump
0
344
solute
0
345
solvent
0
346
starches
0
347
stem cells
0
348
steroids
0
349
stress
0
350
stress response
0
351
stressor
0
352
stroke volume
0
353
substrate
0
354
sucrose
0
355
sugars
0
356
symptoms
0
357
syndrome
0
358
T-cell receptor (TCR)
0
359
T lymphocytes
0
360
Teratogens
0
361
thrombocytes
0
362
tissue
0
363
tonicity
0
364
total body water (TBW)
0
365
Trauma
0
366
Triglycerides
0
367
Tumor
0
368
turgor
0
369
turnover
0
370
unsaturated fatty acid
0
371
vacuoles
0
372
valence electrons
0
373
valence shells
0
374
viruses
0
375
viruses
0