Module 2 Flashcards
Crossing Over
Genetic Exchange between two homologous chromosomes
A single gene has three or more alternative forms
Multiple alleles
Phenotype
the observable expression of the genes present in an Organism
Huntington disease
a human hereditary disease that is caused by a dominant allele but does not show up in affected individuals until they are middle aged
Punnett square
it is useful for predicting the ratios of possible genotypes of a particular combination of alleles
Mendels law of independent assortment has its basis in which of the events of meiosis 1,
alignment of pairs of homologous chromosomes along the middle of the cell
Pleiotrophy
An individual allele has more than one effect on the phenotype
Multifactorial genes:
Multiple genes with environment influences
Polygenic Inheritance:
One trait influenced by many genes
Homozygous recessive conditions:
Albinism, cystic fibrosis, sickle-cell disease, tay-Sachs disease, Phenylketonuria
Dominant Allele Diseases:
Achondroplasia, Alzheimer’s disease, Huntington’s disease, hypercholesterolemia
Types of Fetal Testing:
Amniocentesis (liquid)
Chorionic villus sampling (placenta)
Ultrasound & fetoscopy
Mary Frances Lyon Rosalind Franklin Barbara McClintock, Jennifer Doudna and Emmanuelle Charpenteir Elizabeth H Blackburn
Mary Frances Lyon, X inactivation or lionization
Rosalind Franklin, DNA X ray crystallography
Barbara mcclintock, transposable element TE or jumping jeans
Jennifer Doudna and Emmanuelle Charpenteir, CRISPR
Elizabeth H Blackburn, enzyme telomerase
SRY
a gene present on the Y chromosome that triggers male development
True false, a color blind female can have a son that has a normal vision, color blindness is caused by sex linked recessive allele.
False
Cyclone dependent kinase,
enzyme which adds phosphate to a protein along with cyclones are major control switches motors of for the cell cycle
Each chromosomes consist of two identical
Chromatids
Section of chromosome that codes for a trait
Gene
Tumor suppressor protein activated if DNA damaged
P53
Four DNA mutations:
Deletion (chrom segment) Duplication (repeat segment)
Inversion (reverses segment orientation) Translocation (move segment b/w chrom).
Y-linked inheritance:
Hypertrichosis of ears, webbed toes, porcupine skin
Chromosome theory of inheritance
Chromosomes carry genes which are location at specific locations, Sutton and Boverii.
First to discover solid evidence to associate specific gene with specific chromosome
Thomas Hunt Morgan (students were Alfred Sturtevant (genetic linkage) and Calvin bridges (chrom non-disjunction)
Two alleles segregate during meiosis and end up in different gametes
Law of Segregation