Module 2

Question 1

Median Effective Dose ED50

Answer 1

comparing the potencies of drugs

dose producing a response that is 50 percent

Question 2

Median Lethal Dose LD50

Answer 2

the dose causing mortality in 50 percent of a group of animal

Question 3

What is the margin of safety that exists between the dose needed for the desired effect and the dose that produces unwanted and possibly dangerous side effects

Answer 3

ratio LD50:ED50

the narrower this margin, the more likely it is that the drug will produce unwanted effects.

Question 4

Factors that contribute to this variability in medication reactions

Answer 4

age, genetics, absorption, disease states, drug interactions, and drug intolerance