Module 2: Pharmacokinetics Flashcards
Which of the following statements about the excretion of drugs by the kidney is INCORRECT?
a. In some circumstances, the secretion from the blood to the kidney tubule of one drug can be competitively inhibited by another drug.
b. For many drugs, their reabsorption from the kidney tubule back into the blood is dependent on the pH of the tubular fluid.
c. In general, the more polar metabolites of a drug are better able to be reabsorbed, and are therefore less well excreted, than the parent drug.
d. Glomerular filtration is a passive process that transfers drug from the blood to Bowman’s capsule.
c. In general, the more polar metabolites of a drug are better able to be reabsorbed, and are therefore less well excreted, than the parent drug.
Which one of the following statements about a short term intravenous infusion of a drug is INCORRECT?
a. It can be a useful means of administering a drug with a narrow therapeutic window.
b. Infusion at a constant rate leads to a steady increase in concentration of drug in the plasma.
c. When the infusion is stopped, most drugs show an exponential elimination of drug from the body.
d. The peak concentration observed following a short term intravenous infusion is always less than that observed when the same dose of the drug is given as a bolus (i.e. all-at-once) dose.
b. Infusion at a constant rate leads to a steady increase in concentration of drug in the plasma.
Which one of the following statements regarding volume of distribution is correct?
a. It is a key factor in determining how frequently a drug should be administered.
b. It is defined as the amount of drug in the entire body divided by the concentration of drug in the plasma.
c. It indicates the volume of drug that distributes into the brain.
d. It describes the rate at which a drug distributes throughout the body.
b. It is defined as the amount of drug in the entire body divided by the concentration of drug in the plasma.
Which one of the following statements regarding bioavailability is INCORRECT?
a. It is an important factor to consider when determining the dose of a drug.
b. For drugs administered intravenously, it can be affected by the first pass hepatic metabolism.
c. It can be affected by the extent of absorption from the gastrointestinal tract.
d. It is usually defined as the proportion of active drug that enters the systemic circulation following administration.
b. For drugs administered intravenously, it can be affected by the first pass hepatic metabolism.
