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Quiz questions BC modules 1-5 > Module 5 Quiz Questions > Flashcards

Module 5 Quiz Questions Flashcards

1
Q

What molecule does Tamoxifen bind to?

A

Estrogen Receptor

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2
Q

What settings may Tamoxifen be used in to treat breast cancer?

A
  1. Risk reduction
  2. Adjuvant Therapy
  3. Metastatic breast cancer
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3
Q

Match end points for EORTC trial (Tamoxifen vs Exemestane)

  • median PFS exemestane
  • median PFS tamoxifen
  • median OS exemestane
  • median OS tamoxifen
A
  • median PFS exemestane - 9.9 months
  • median PFS tamoxifen - 5.8 months
  • median OS exemestane - 37.2 months
  • median OS tamoxifen - 43.3 months
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4
Q

What is the mechanism of action of Letrozole?

A

inhibits conversion of androgens to estrogen

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5
Q

In what settings can letrozole be used to treat breast cancer?

A
  • Neo adjuvant
  • Adjuvant and extended adjuvant
  • Metastic
    • NOT risk reduction
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6
Q

What was the mean TTP in patients receiving letrozole in the study comparing letrozole to megestrol acetate as second line therapy in post menopause with advanced Metastatic cancer?

A

23.6%

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7
Q

What is the mechanism of action of anastrozole?

A

Inhibits the conversion of androgens to estrogens

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8
Q

In what settings can anastrozole be used to treast BC?

A
  • neo
  • adj
  • metastic
    • all the above
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9
Q

What percentage of patients in the North American trial receiving anastrozole achieved OR?

A

21%

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10
Q

What enzyme does exemestane inhibit?

A

Aromatase

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11
Q

In what settings can exemestane be used to treat BC?

A

Neo
Adj
Metastatic
*** NOT risk reduction

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12
Q

Which end points showed a significant advantage for exemestane in a phase 3 trial?

A

Survival
Overall Success
TTP
*** NOT OR

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13
Q

What is the mechanism of action for fulvestrant?

A

competitively inhibits binding of estrogen to the estrogen receptor

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14
Q

In what settings can fulvestrant be used to treat BC?

A

metastatic breast cancer

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15
Q

What is the dose and method of admin for fulvestrant?

A

500 IM

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16
Q

In the CONFIRM study, PFS was significantly longer for Fulvestrant 500mg corresponding to a ………. reduction in the risk of progression

A

20%

17
Q

In the CONFIRM trial which of the following was a serious AE reported more than 2 patients

A

dyspnea

18
Q

What is the mechanism of action of everolimus?

A

inhibitor of mTor

19
Q

In what settings may everolimus be used to treat BC?

A

metastatic breast cancer

20
Q

In the BOLERO-2 study the median PFS based on local assessment …….. months for combination vs. …… months for the extremestane alone group?

A
  1. 9 months

2. 8 months

21
Q

In the BOLERO-2 study which of the following was one of the most common grade 3 or 4 AE reported in the combination therapy group?

A

stomatitus

Quiz questions BC modules 1-5 (5 decks)

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