Module 6: Forensic: Sexual Assault, Sexual Child, Lead, Carbon Monoxide, Ethanol Flashcards Preview

Pathology Post Midterm > Module 6: Forensic: Sexual Assault, Sexual Child, Lead, Carbon Monoxide, Ethanol > Flashcards

Flashcards in Module 6: Forensic: Sexual Assault, Sexual Child, Lead, Carbon Monoxide, Ethanol Deck (39):

First starting off sexual assault we are going to discuss sexual assault. what is it?

Unwanted sexual contact that causes discomfort, fright or intimidation


How do you approach the patient in a sexual assault case?

Private Room ASAP: remain in clothing
--no urinating, defecating, drinking, eating or smoking
--social support and offer to contact law enforcement
--informed consent for examination
72 hour rule: STD and pregnancy prophylaxis, collecting evidence and documenting injuries


How do you get a history and physical in a sexual abuse patient?

Patients own words and document affect
--document physical signs of trauma (genital and non genital)
--tears (tenderness), redness, abrasions, contusions, swelling


Does absence of injury rule out assault?



What evidence should be collected in a sexual assault case?

Sexual assault evidence collection kit
---proper collection and presentation; chain of custody
Drug Facilitated sexual assault (GHB, hallucinogens, sedative-hypnotics, opioids)
--Toluding Blue Dye (normal skin surface has anucleated cells but trauma exposes deeper nucleated cells)


Moving on to sexual abuse of a child, what is the definition of this?

Engaging of a child in sexual activities when child is developmentally unprepared or violates social and legal taboos
--oral-genital, genital, anal, non touching


What is high index of suspicion in sexual abuse of a child?

Coerced into secrecy and general behavioral problems (sleep, enuresis)


What are specific signs and symptoms as well as patient history for sexual abuse of children?

Signs: rectal/genital pain, bleeding, infections, STDs, precocious sexual behavior
History: quite environment and caring attitude
--interview all sources and get a comprehensive medical history


How is a physical exam of a sexually abused child performed?

Have a trusted supportive adult present
--slow and complete
--consider general anesthesia
A normal genital/anal exam does not rule out abuse


Explain diagnosis and follow up procedures for a sexual abuse child case

Dx: careful documentation and discuss with caregivers and child while remaining neutral
Follow up: asses adequacy of healing, document changes, repeated tests for STDs, assess coping skills
Most common findings in sexually abused children is a norma exam (b.c perpetrator does not want to hurt the child)


What are normal findings in a non abused child?

Common: Erythema, pigmentation, congestion, anal fissures (Associated with constipation)
Anal dilation: constipation, prone position, neurological disease, post mortem
Normal variants: midline wedge-shaped smooth areas (diastasis ani), midline anal skin tags, folds and failure of midline fusion


Moving on to lead, what are sources?

Air, Soil, water, dust, ceramics, food/soft drinks, moonshine, toys, batteries and ammunition


What is the absorption and distribution of lead?

Adults ingest 100-500mg daily (10% absorbed)
--kids ingest less but 50% absorbed
--enhanced with mineral (calcium/iron/zinc) deficiencies
Distribution: bone and teeth (85% --- lead lines), blood (5-10%) and soft tissues


What are the biochemical effects of lead?

Inhibits iron corporation into heme
competes with calcium
inhibits membrane associated enzymes
impairs production of active vit D --- calcium deficiency
Fatal lead poisoning due to cardioresp arrest and cerebral edema
Tx with chelation therapy


Moving on to Carbon Monoxide, what is this/

Colorless, odorless gas thats a byproduct of combustion (gas, oil, coal, wood, natural gas and cigarette smoke)
--cause of half of all fire deaths


What is the pathogenesis for carbon monoxide poisoning?

CO has 230-300 times the affinity for Hb as oxygen -- cherry red discoloration of skin
--impairs release of oxygen from Hb
--direct toxic cellular effect
--greater degree of hypoxemia than an equivalent degree of anemia


Moving onto ethanol it is the most widely used/abused. What are acute effects and mechanism?

Acute effects: CNS depressant, fatty liver
--asymptomatic, acute and reversible
--mechanism: increased catabolism of peripheral fat, increased NADH stimulates lipid synthesis, decreased fatty acid oxidation, decreased transport lipoproteins from liver


What are the chronic effects (systemic, vitamin deficiencies) of ethanol on the GI system?

GI: liver cirrhosis, steatohepatitis, pancreatitis, gastritis, ulceration, varices, oral/esophageal cancer


What are the chronic effects of ethanol on the nervous system?

Nervous system: peripheral neuropathy, wernicke-korsakoff, cerebral atrophy and cerebellar degeneration


What are the chronic effects of ethanol on the cardiovascular system/

Toxic effects: HTN and dilated cardiomyopathy
Protective effects: increased HDL and decreased platelet aggregation


What are the chronic effects of ethanol on the reproductive system?

Fetal alcohol syndrome (most common preventable cause of mental retardation)
--short palpebral fissures
--flat midface
--thin upper lip
--epicanthal folds
--low nasal bridge
--short nose


What is the pharmacology of ethanol?

Absorption: stomach and small intestine
Metabolism: 9gm/her and 90% metabolized to acetaldehyde and acetic acid in gastric mucosa and liver
Elimination: 10% excreted unchanged in urine, sweat and breath


Moving on to Ethylene Glycol, what is it?

Colorless, odorless, sweet alcohol in antifreeze, deicing and industrial solvents
fatal dose= 100-200mL


What are the stages of ethylene glycol poisoning?

Neurologic: 0.5-12 Hrs: nausea/vomiting, inebriation/euphoria and CNS depression and seizures
Cardiopulmonary: 12-24 hrs: compensatory hyperventilation and heart failure
Renal: 24-72 hours: acute tubular necrosis


How is a dx of ethylene glycol poisoning made?

Intoxication to come with severe metabolic acidosis, seizures to acute renal failure and death
--high anion gap: greater than 18mEq/L
--Urine microscopy: sodium fluorescein and calcium oxalate crystals


Moving on to Methanol (Wood Alcohol), what is it?

Colorless, clear alcohol found in antifreeze, pain and varnish solvent, methylated spirits and alternative energy
--fatal dose: 15-500mL


What are the stages of methanol (Wood alcohol) poisoning?

Early: transient euphoria, inebriation, drowsy
Latent: 6-30 hrs: blurred vision, abd pain, vomiting, metabolized to formic acid and formaldehyde
Delayed: systemic effects of metabolic acidosis (high anion gap)
CNS: mild/moderate: HA and severe: parkinson like syndrome
Ocular: blurred vision to blindness
GI: abd pain
Cardio: resp arrest and shock


Moving on to drug abuse, what are therapeutic drugs?

Adverse drug reaction:
---undesired response at therapeutic doses
--predictable or idiopathic/idiosyncratic
Prescription drug abuse


What are risk factors for drug abuse?

Family history
Psychiatric disorders
Ethanol abuse
Access and peer pressure


What are the top drugs of abuse?

Pain relievers


Moving on to opioid analgesics, what does this include?



What are acute effects of opioid analgesics?

Anxiolytic, sedation, mood changes, nausea, resp depression
Convulsion: cardioresp arrest, death


What are chronic effects of opioid analgesics?

Tolerance and dependence
Infectious complications of IVDA: cellulitis, endocarditis, viral hep and pneumonia


In regards to heroin (diacetylmorphine), what are some features?

Source = poppy plant
Cutting agents: talc, quinine
Routes: IV or SQ injection, smoking and snorting
Effects: euphoria, hallucinations, sedation
Adverse effects from: heroin and/or cutting agents, HSR, injection


What are the toxic effects of heroin (Diacetylmorphine)?

Sudden death: profound resp depression, arrhythmia, pul edema
Pulmonary: edema, septic emboli, abscess
Skin: abscess, cellulitis, ulceration, vein thrombosis and scarring/hyperpigmentation
Infection: endocarditis, hep and AIDS


Finally cocaine, what are some features/

Source: leaves of erythroxylon coca
Forms: cocaine HCL + cutting agent (talc and lactose) or crack cocaine
Routes: snorted, smoked, ingested and injected
Mechanism: blocks reuptake of DA, E and NE


What are the effects of cocaine?

Fast acting stimulant of short duration
--rush: pleasure, strength, power, and excitement
--high: increased alertness, confidence, disinhibition
--side effects: weight loss, insomnia and fatigue


What are the toxic effects of cocaine?

Toxic effects:
CNS: hyperpyrexia, seizure
Cardio: increased BP and HR
Pulmonary dysfunction
Pregnancy: abruption
Other: perforated nasal septum


In regards to cocaine what is fatal excited delirium syndrome (acute onset)?

Delirium (transient disturbance in consciousness and cognition and hallucinations)
Violent behavior
Sudden cardiac death
History of chronic stimulant abuse
Fatal Arrhythmia precipitated by ischemia
---accelerated atherosclerosis and thrombosis

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