Module 9: Autoimmune Disease Flashcards Preview

HSCI 300 Immunology > Module 9: Autoimmune Disease > Flashcards

Flashcards in Module 9: Autoimmune Disease Deck (10)
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1
Q

What is central tolerance?

A

Deletion of T and B cells that have specificity to self antigens
Occurs in bone marrow for B cells and in the thymus for T cells

2
Q

What is peripheral tolerance?

A

Mechanisms at the local level which induce a state of inactivity of lymphocytes even in the presence of antigen

3
Q

Antibody seen in Hashimoto’s Thyroiditis?

A

TPO antibody/Thyroglobulin antibody

4
Q

Antibody seen in myasthenia gravis?

A

Cholinesterase receptor antibody

5
Q

Antibody seen in SLE?

A

DNA, ANA, anti-SMA

6
Q

Antibody seen in graves disease?

A

TSH receptor antibody

7
Q

Antibody seen in rheumatoid arthritis?

A

Rheumatoid factor

8
Q

Antibody seen in insulin dependent diabetes mellitus?

A

Antibody to islet cell antigens

9
Q

Antibody seen in Goodpasture’s syndrome?

A

Basement membrane antibody

10
Q

Antibody seen in primary bilary cirrhosis?

A

Mitochondrial antibody