Molecular Basis of Inheritance Flashcards
(22 cards)
Who won the Nobel Price in 1962?
Watson and Crick
Who first isolated nucleic DNA from pus cells and called it nuclein?
Friedrich Meischer
Who identified the three constituents of nucleic acids?
Albert Kossel
Phosphodiester bond?
A phosphate connects 5’C of pentose sugar to 3’C of another pentose sugar.
Ribose?
C5 H10 O5, in RNA
Deoxyribose
C5 H10 O4, in DNA
Furanose ring structure
the type of structure that the sugar molecules have
Purines
purines are 9- membered dicyclic rings attached together at the 4 and 5 positions while having nitrogens at positions 3, 7, and 9
the two purines
adenine and guanine
Pyrimidines
pyrimidines are 6 membered monocyclic ring with nitrogen at 1 and 3 position.
the three pyrimidines
cytosine, thymine, and uracil
6-amino purine C5H5N5
adenine
6-oxy-2-aminopurine-C5H5N5O
guanine
2,4-dioxy-5-methylpyrimidine C5H6N2O2
thymine
2 oxy 4 amino pyrimidine c4h5n3o
cytosine
2,4 dioxypyrimidine C4H4N2O2
uracil
nucleoside
sugar + nitrogenous base pair
nucleotide
phosphate + nucleoside
5’ end
free phosphate side
3’ end
free pentose side
Avery, MacLeod and McCarty
presented first evidence that DNA is genetic material by genetic transformation experiment
Hershy and Chase
showed that the DNA is the carrier of genetic information from parent to offspring