Molecular Basis Of Smooth Muscle Contraction

Question 1

Binding of ACh to _______ receptor causes increase of ___ influx or activation of enzyme _____ binds to sites of SR causing release of stored Ca2++

Answer 1

Muscarinic, Ca2++; phospholipase C

Question 2

Ca2+ binds to _____ which is the Ca2+ binding site in cytosol, which activates myosin light chain kinase (MLCK)

Answer 2

Calmodulin

Question 3

Phosphorylation of meromyosin consumes ____ that cause an increase in _______ activity and binding of myosin-actin

Answer 3

ATP, myosin ATPase

Question 4

Contraction cycle is continued as long as ____ is elevated

Answer 4

Ca2+

Question 5

Dephosphorylation of mysoin is by enzyme _____ which causes relaxation or sustained contraction due to _____ bridge

Answer 5

Myosin light chain phosphatase (MLCP); latch