Molecular Biology: 3 Metabolic Response to Ischemia and Reperfusion Flashcards
1
Q
What is important to remember about Aerobic Energy Production?
A
O2 is needed
2
Q
What are the Primary Cardiac Fuel Sources?
A
3
Q
What is the requirement for Mitochondrial Energy Production?
A
4
Q
What are the Effects of Ischemia & Reperfusion on Aerobic Energy Production?
A
5
Q
What are the Consequences of Hypoxia?
A
- Aerobic glycolysis and fatty acid oxydation slow down
- ATP in short supply
- Anaerobic glycolysis speeds up (if glucose available, normally comes from blood)
- Cardiac cells have limited glycogen stores (compared to skeletal muscle)
- Lactate increases and pH drops
6
Q
What are the Consequences of Reperfusion?
A
7
Q
What are the Reactive Oxygen Species?
A
8
Q
Describe a ROS mediated reperfusion injury
A
9
Q
What is the relationship between Infarct Size and Time
A
10
Q
Describe Ischemic Conditioning and Reperfusion Injury
A
11
Q
Describe Energy Transfer via Creatine Kinase
A
12
Q
Describe the components of Creatine Kinase
A
13
Q
Describe the Plasma Levels of CK-MB and Cardiac Troponin Following MI
A
