Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PassMed Revision > Mon 11th Jan > Flashcards

Mon 11th Jan Flashcards

1
Q

Ciprofloxacin

A

CI: G6PD deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Paracetamol overdose: poor prognosis

A

increased Prothrombin time
arterial pH
creatinine
encephalopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Vancomycin

A

requires therapeutic drug monitoring > accumulation + toxicity in renal impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Heparin-induced thrombocytopenia

A

auto-antibodies = heparin + platelet factor IV

switch to: direct thrombin inhibitor = argatroban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amiodarone: adverse effects

A 
thyroid dysfunction: hypothyroidism + hyper-thyroidism
corneal deposits
pulmonary fibrosis/pneumonitis
liver fibrosis/hepatitis
peripheral neuropathy, myopathy
photosensitivity
'slate-grey' appearance
thrombophlebitis and injection site reactions
bradycardia
lengths QT interval
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Amiodarone: drug interactions

A

decreased metabolism of warfarin > increased INR

increased digoxin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ethylene glycol: poisoning

A

in antifreeze
attempted suicide

Metabolic acidosis with a high anion gap and high osmolar gap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diclofenac

A

contraindicated = any form of cardiovascular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Proton pump inhibitors

A

hypomagnesaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PDE 5 inhibitors = sildenafil

A

contraindicated = nitrates and nicorandil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pulmonary fibrosis: drug-induced

A

> Antibiotics = nitrofurantoin
Amiodarone
Chemotherapy
Anti-Rheumatoid: Methotrexate + sulfasalazine
Cytotoxic agents: busulphan, bleomycin
Ergot-derived dopamine receptor agonists: (bromocriptine, cabergoline, pergolide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Severe lithium toxicity

A

excess of 2 mmol/L
neurological symptoms or renal failure are present

haemodialysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cyclical combined HRT

A

LMP was less than 1 year ago

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Adult Life Support (ALS): Adrenaline doses

A

anaphylaxis: 0.5ml 1:1,000 IM

cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Severe pain

A

V morphine titrated in 1-2mg boluses until comfortable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Lithium toxicity

A

precipitated by thiazides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Absolute contraindication to the use of regional anaesthesia

A

Therapeutic anticoagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Within 1 hour of Paracetamol ingestion

A

Activated charcoal

prevent further paracetamol being absorbed into the circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Immediate N-acetylcysteine (NAC)

A

Paracetamol overdose = staggered or if there is doubt about the chronology of the overdose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Amitriptyline

A

cause urinary retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Ecstasy poisoning

A

neurological: agitation, anxiety, confusion, ataxia
cardiovascular: tachycardia, hypertension
hyponatraemia
hyperthermia = give dantrolene
rhabdomyolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Hypokalaemia

A

predisposes patients to digoxin toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Methanol poisoning

A

fomepizole or ethanol

haemodialysis

24
Q

Digoxin

A

Digoxin-specific antibody fragments

25
Isoniazid
Peripheral neuropathy is a commonly recognised side effect
26
Rifampicin
``` Most common side effects: Orange bodily fluids, rash, hepatotoxicity, drug interactions ```
27
Gentamicin
Ototoxicity + nephrotoxicity Contraindications = myasthenia gravis
28
Sildenafil
``` Side effects: headaches, facial flushing, dyspepsia, transient blue-green tingeing of vision ```
29
Tricyclic antidepressants: Overdose
IV bicarbonate
30
Paracetamol: Overdose
Start NAC immediately if: > uncertainty about the time of overdose, but it is potentially toxic > staggered over a time period longer than an hour > plasma-paracetamol level is over the treatment line on the treatment graph > 8-36 hours before presenting
31
Tuberculosis: treatment
Liver functions tests should be checked in all cases
32
St John's Wort
inducer of the P450 system and can decrease ciclosporin levels, leading to transplant rejection
33
Amiodarone
SE: both corneal opacities and optic neuritis
34
Ciclosporin
SE: cause nephrotoxicity
35
Digoxin toxicity
within 8 to 12 hours of the last dose
36
Cyclizine: caution
heart failure as it may cause a fall in cardiac output
37
Salicylate poisoning
first causes respiratory alkalosis
38
Metformin: CI
contraindicated in those with eGFR < 30
39
Ciprofloxacin: SE
lowers the seizure threshold
40
Clinical features of digoxin toxicity
GIT: nausea, vomiting, anorexia, diarrhoea Visual: blurred vision, yellow/green discolouration, haloes CVS: palpitations, syncope, dyspnoea CNS: confusion, dizziness, delirium, fatigue
41
Bendroflumethiazide: SE
Hyponatraemia
42
Atenolol: SE
Cold peripheries
43
Ecstasy: Overdose
Serotonin syndrome
44
Ethambutol: SE
optic neuropathy and development of colour blindness discontinued or pyridoxine (vitamin B6) is given concurrently
45
Lithium overdose: risk factors
Dehydration
46
Aspirin
Blocking the action of both cyclooxygenase-1 and 2. Cyclooxygenase is responsible for prostaglandin, prostacyclin and thromboxane synthesis blocking of thromboxane A2 formation in platelets reduces the ability of platelets to aggregate
47
Metoclopramide
Dopamine antagonist treat migraines prokinetic agent to speed up gastric motility
48
Histamine-1 antagonist
treat hayfever
49
Sinus congestion
Alpha agonist
50
Salicylates: Overdose
tinnitus, anxiety diaphoresis Respiratory alkalosis initially due to hyperventilation, Then > Metabolic acidosis due to lactic acid accumulation
51
Sodium valproate: SE
enzyme INhibitor so can INcrease warfarin levels if used concurrently
52
Paracetamol overdose: acute alcohol intake
Not associated with an increased risk of developing hepatotoxicity and may actually be protective
53
DPP4-inhibitors
Gliptins Sitagliptin
54
Sitagliptin: SE
acute pancreatitis and should be stopped if it is suspected and reported by Yellow Card
55
Finasteride
5 alpha reductase inhibitor which converts testosterone into DHT treat: benign prostatic hyperplasia

PassMed Revision (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions