Monday 2 - Nikcevich - Acute Leukemia

Question 1

increased risk of what with Down Syndrome, Ataxia telangiectasia, Fanconi anemia, Li Fraumeni syndrome, Wiskott-Aldrich, familial leukemia, myelodysplasia, PNH,

Answer 1

AML

Question 2

Exposure to what specific compounds can cause AML

Answer 2

prior chemo
radiation
BENZENE

Question 3

gum shit appears in which leukemias

Answer 3

monocytic (M4,5)

Question 4

what count of what cells is indicitive of hyperleukocytosis

what do you do when you see it

Answer 4

blast cells >100,000 count/ml

Tx with hydroxyurea, leukopheresis, chemo

Question 5

FAB and WHO classification of AML

Answer 5

FAB >30% BM myelocytes
M1, M1, etc

WHO >20%
more modern, AML with cytogenetic abnormalities, etc

Question 6

What is the most important part to look at in someones labs with AML

Answer 6

CYTOGENITICS

Question 7

auer rods - good or bad prognostically

Answer 7

good

Question 8

what cytogenetic abnormality do you see with prior chemo (cyclophosphamide, alkylating agents)?

Answer 8

11q23 - unfavorable genetics

Question 9

good risk genetics for consolidation chemotherapy

Answer 9

8;21, inv16, 15;17

Question 10

what is meant by autologous stem cell transplants

Answer 10

take cells from patient, give chemo, give cells back.

rare

Question 11

what chemotherapeutic drug is often given to combat AML

Answer 11

anthracycline

Question 12

what drugs cause an elevated PTT

Answer 12

coumadin, rat poison

Question 13

what AML is it if promyelocytes are extremely granular?

Answer 13

M3

Question 14

drugs that people can take that would cause demargination of neutrophils

Answer 14

steroids

Question 15

do you do a spinal tap for aML?

Answer 15

yea