Monoclonal Antibodies Flashcards
1
Q
What is a monoclonal antibody?
A
antibodies made by a single b-lymphocyte clone
2
Q
What is the general suffix for a fully human naked monoclonal antibody?
A
-umab
3
Q
How do monoclonal antibodies work?
A
Bind to cell surface receptors to activate or inhibit signalling within the cell. Blocking inhibitory effects on T cells
4
Q
What 2 pathways can monoclonal antibody binding activate?
A
Antibody-dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity
5
Q
Which monoclonal antibody is commonly used in lymphoma?
A
Rituximab
