monoclonal meds Flashcards
1
Q
Palivizumab (synagis)
A
Phrophylaxis
Tx: respiratory syncytial virus prophylaxis for infants
-HUMANIZED
anti-RSV F protein
2
Q
Trastuzumab (herceptin)
A
targets tumors -anti-ErbB-2 -uses opsonization, C cascade, ADCC -HUMANIZED HER2/neu MoAb for breast cancer mets
3
Q
ibritumomab tiuxetan
- zevalin
- rituxan
A
cancer detection and tx
- cells possessing specific tumor antigens are targeted for imaging when radioisotope labeled MoAb binds
- MURINE
- targets B cell marker CD20
- targeting small tumors and mets with moAb-toxin or moAb-radioisotope conjugates
4
Q
Muromonab-CD3
orthoclone OKT3
A
Prevention of allograft rejection using anti-CD3
- receptor blockade
- MURINE
5
Q
Omalizumab (Xolair)
A
hypersensitivity tx
- anti-IgE therapy for severe allergies and allergic asthma
- HUMANIZED
6
Q
Gemtuzumab ozogamicin (mylotarg)
A
target cancer cell antigen
- anti - CD33 therapy designed to treat acute myeloid leukemia
- antibody bound calicheamicin leading to intermnalization, DNA binding and cell death
7
Q
Muromonab-CD3
A
treat autoimmune diseases -tx of type 1 DM using anti-CD3 -receptor blockade MURINE -reduce T cell number
8
Q
Natalizumab
A
Inhibition of leukocyte migration
- HUMANIZED against the cell adhesion molecule gamma4-integrin
- used in MS and crohn’s
9
Q
Daclizumab (zenapax)
A
Neutralization of cytokines
- IL-2 receptor blockade
- HUMANIZED
- licenced to prevent renal allograft rejection
- blocks access of IL-2 to its receptor preventing activation
