Mood and anxiety disorder pharmacology

Question 1

What is the prototype SSRI?

Answer 1

Fluoxetine

Question 2

Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and escitalopram belong to which class of antidepressants?

Answer 2

SSRIs

Question 3

What is the prototype SNRI?

Answer 3

Venlafaxine

Question 4

Venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, and milnacipran belong to which class of antidepressants?

Answer 4

SNRIs

Question 5

Buproprion is an orphan drug of which class of antidepressant?

Answer 5

“Amphetamine-related”

Question 6

Which antidepressant is a 5-HT1a/alpha 1 partial agonist?

Answer 6

Buspirone

Question 7

What is the prototype 5-HT2 /alpha 2 antagonist?

Answer 7

Mirtazepine

Question 8

Mirtazepine and trazodone belong to which class of antidepressant?

Answer 8

5-HT2/alpha 2 antagonists

Question 9

What is the prototype tertiary amine TCAD?

Answer 9

Amitryptyline

Question 10

Amitryptyline, imipramine, clomipramine, and doxepin belong to which class of antidepressants?

Answer 10

Tertiary amine TCADs

Question 11

What is the prototype secondary amine TCAD?

Answer 11

Nortyptyline

Question 12

Nortyptyline, desipramine, and amoxapine belong to which class of antidepressants?

Answer 12

Secondary amine TCADs

Question 13

What is the prototype MAOI?

Answer 13

Tranylcypromine

Question 14

Tranylcypromine, seligiline, phenelzine, and isocaboxazid belong to which class of antidepressants?

Answer 14

MAOIs

Question 15

Which anticonvulsants are used to control manic symptoms of bipolar disorder?

Answer 15

Valproate, carbamazepine, and oxycarbazepine

Question 16

Valproate, carbamazepine, and oxycarbazepine are used to control what symptoms in bipolar disorder?

Answer 16

Manic symptoms

Question 17

Which anticonvulsant are used to control depressive symptoms of bipolar disorder?

Answer 17

Lamotrigine

Question 18

What is the prototype antipsychotic used to control psychotic symptoms of bipolar disorder?

Answer 18

Olanzepine

Question 19

Olanzepine, quetiapine, lurasidone, and aripriprazole belong to which class of drug?

Answer 19

Antipsychotics

Question 20

What is the neurotrophic hypothesis of depression?

Answer 20

Glucocorticoids depress the synthesis of BDNF, which decreases neurogenesis (especially in the dentate gyrus)

Question 21

What is the monoamine hypothesis of depression?

Answer 21

An imbalance in NE/DA systems and 5-HT systems influence each other neurophysioloically; depressants result from an imbalance between these systems

Question 22

What is the mechanism of action of SSRIs?

Answer 22

Block reuptake of 5-HT via the 5-HT transporter in serotonergic nerve terminals

Question 23

What is the mechanism of action of SNRIs?

Answer 23

Block reuptake of 5-HT via the 5-HT transporter in serotonergic nerve terminals AND block reuptake of NE via NE transporter in noradrenergic nerve terminals

Question 24

Do SNRIs have a greater affinity for NE or 5-HT transporters?

Answer 24

5-HT transporters

Question 25

What is the mechanism of action of buproprion?

Answer 25

Enhances NE and DA release at noradrenergic nerve terminals

Question 26

What is the mechanism of action of buspirone?

Answer 26

Partial agonist at 5-HT1a receptors and weak alpha 1-adrenergic partial agonist on postsynaptic neurons

Question 27

What is the mechanism of action of mirtazepine and trazodone?

Answer 27

Antagonist at 5-HT2 receptors, alpha 2 adrenergic receptors, and H1 receptors on noradrenergic and serotonergic nerve terminals