Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psychiatry > Mood Disorder Pharm > Flashcards

Mood Disorder Pharm Flashcards

Mood Disorders

1
Q

citalopram side effects

A

GI, Sleep, sexual, sweating, Na+, mania

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

citalopram is what class of AD

A

SSRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

citalopram interaction

A

2D6 inhibition (weak) can increase MAO-Is and TCA and QTc prolonation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

citalopram black box warning

A

increase suicidal ideation up to 25 yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

fluoxetine AD drug class

A

SSRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

paroxetine AD drug class

A

SSRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

sertraline AD drug class

A

SSRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

fluivoxamine AD drug class

A

SSRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

chlomipramine class

A

TCA/ SSRi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SSRIs interact w/ which receptors

A

a/b and adrenergic receptors, histamine, dopamine, muscarinic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

most cell bodies that use serotonin are where?

A

raphe nucleus in brainstem/ midbrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

venlafaxine is what class of AD

A

SNRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

venlafaxine side effects

A

GI, sexual, sleep, sweating, Na+, mania, diastolic BP increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

venlafaxine black box warning

A

SI up to 25

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

venlafaxine interactions

A

2D6 (very weak)
slight increase of MAO-Is and TCAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

venlafaxine– issue w/ discontinusation

A

severe withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

desvenlafaxine AD drug class

A

SNRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

duloxetine AD drug class

A

SNRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

TCAs have dual action on which NTs

A

serotonin and norepi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

tertiary amines are more specific for serotonin or norpei

A

serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

secondary amines are more specific for serotonin or norpei

A

norepi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

nortryptiline class and mechanism

A

secondary amine, TCA – Norepi and serotonin modulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

nortryptiline
is a metabolite of what?

A

amitryptiline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

nortryptiline side effects

A

wt gain, sedation, ACh, hypotension, arrhythmias, sexual, sweating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

nortryptiline interaction

A

MAO-I, TCA’s, tramadol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

imipramine AD drug class

A

tertiary TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

amitriptyline AD drug class

A

TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

desipramine AD drug class

A

secondary TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

which 2 dopamine pathways play a role in depression

A

mesocortical and mesolimbic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

bupropion class

A

NDRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

bupropion Side effects

A

insomnia, tremor, tinnitus, seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

bupropion interactions

A

MAOI, tCA, tramadol, levodopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

avoid bupropion in which 2 situations

A

eating disorders and seizure disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

bupropion least likely to

A

cause mania and weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

bupropion helps w/ which side effect

A

sexual SE of ADs
can improve sex drive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

caveat w/ MAO-I prescription ( what do you have to do before and after you prescribe)

A

need to week wash out period

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

signs of serotonin syndrom e

A

Triad: Mental status changes, autonomic instability, neuromuscular signs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

phenelzine AD class

A

MAO-I

39
Q

phenelzine sedating or stimulating?

A

sedating

40
Q

tranylcipromine sedating or stimulating?

A

stimulating

41
Q

mirtazapine side effects

A

sedating, wt gain

42
Q

mirtazapine interactions

A

don’t combine w/ MAO-I

43
Q

mirtazapine relationshipo to sexual SEs

A

low sexual SE

44
Q

mirtazapine class/ mechanism

A

Noradrenergic and Specific Serotonin Antidepressant NaSSA Increases Dual reuptake and norepi

45
Q

Nefazodone class/mechanism

A

SARI (serotonin Antagonist and reuptake inhibitor) Increases Dual reuptake and norepi

46
Q

Trazodone class/mechanism

A

Increases Dual reuptake serotonin and norepi

47
Q

Benzodiazepine 5 therapeutic uses

A

sedative, anxiolytic, seizure control, muscle relaxant, anterograde amnesia

48
Q

Diazepam selective or non-selective

A

non-selective

49
Q

Diazepam side effects

A

sedation, depression, amnesia, ataxia, dependence, withdrawal

50
Q

Diazepam interaction

A

CNS depressants, opiate, cimetidine

51
Q

what drug is given to reverse BZD effects

A

flumazenil

52
Q

t/f BZDs have active metabolites

A

t

53
Q

how is Diazepam cleard

A

hepatically mostly

54
Q

Diazepam half life

A

20-50 hours

55
Q

chlordiazepoxide drug class

A

BZD

56
Q

chlordiazepoxide half life

A

30-May

57
Q

clonazepam half life

A

18-50 hours

58
Q

lorazepam half life

A

10-20 hours

59
Q

alprazolam half life

A

6-12 hours

60
Q

how is lorazepam cleared?

A

renally

61
Q

which BZD is probably most addictive?

A

alprazolam

62
Q

Zolpidem selective for which gaba subunit

A

a1

63
Q

zolpidem brand name

A

ambien

64
Q

Buspirone/ BuSpar mechanism

A

serotonin partial agonist

65
Q

buspirone use

A

GAD and augment MDD

66
Q

Buspirone side effects

A

dizziness, HA, sedation, nervous/restless

67
Q

Buspirone interactions

A

MAO-I

68
Q

signs of Lithium toxicity

A

drowsiness, ataxia, nausea, vomiting, and diarrhea

69
Q

Lithium side effects

A

lethargy and weight gain

70
Q

Lithium volume of distribution

A

approximates total body water

71
Q

Lithium excreted how

A

urine

72
Q

Lithium interactions

A

NSAIDs, anything that changes total body water ie hypertension drugs

73
Q

caveat w/ Lithium dosing

A

very narrow therapeutic window

74
Q

which anticonvulants are used to treat mania

A

Valproic acid, carbamazepine, oxcarbazepine, and lamotrigine

75
Q

Which antipsychotics used for mania?

A

olanazpine

76
Q

valproic acid metabolism

A

50% UGT, 40% beta-ox, 10% CYP450

77
Q

valproic acid half life

A

16h

78
Q

valproic acid toxicity

A

liver tox, heme tox

79
Q

valproic acid interactions

A

reduces clearance of carbamazepine and lamotrigine

80
Q

valproic acid suggested mechanism

A

incresases GABA effect, NMDA inhibition, block voltage gated sodium and calcium channels

81
Q

carbamazepine mechanism

A

Na channel blockers which slows repetitive firing

82
Q

carbamazepine toxicity

A

aplastic anemia, drowsiness, HeadAche

83
Q

carbamazepine interactions

A

p450 inducer, Ca channel blocks, NSAID

84
Q

Lamotrigine mechanism

A

Na and Glutamate blocker

85
Q

Lamotrigine advantage as mood stabilizer

A

allso effective in depressed phase of BP disorder

86
Q

lamotrigine metabolsm

A

glucuronidation

87
Q

oxcarbazepine drug class

A

anticonvulsant, mood stabilizer

88
Q

oxcarbazepine mechanism

A

blocks voltage gated Na channels

89
Q

oxcarbazepine half life

A

1-5 hours

90
Q

lamotrigine half life

A

13.5 hours

91
Q

what is preferred bipolar drug for pregnancy

A

olanzapine

92
Q

what drug classes used in acute management of manic episode

A

atypical anti-psychotic and mood stabilizer

93
Q

olanzapine onset (qualitiatve)

A

fast b/c dissolves quickly

94
Q

is lithium metabolized by cyp450 system

A

no

Psychiatry (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions