Mood Disorders KT Flashcards

(67 cards)

1
Q

antipsychotic (neuroleptic) drugs

A

relive schizophrenia and similar conditions

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2
Q

atypical antidepressants

A

miscellaneous group of drugs with antidepressant effects with mild side effetcs
inhibits reuptake of dopamine and some norepinephrine, but NOT SEROTONIN

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3
Q

autism spectrum disorder

A

affects ability to connect and communicate

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4
Q

bipolar disorder

A

alternating states of depression and mania

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5
Q

butyrophenones

A

includes halperidol (Haldol) - block dopamine synapse

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6
Q

chlorpromazine

A

relieves positive symptoms of schizophrenia
first drug used to treat schizophrenia

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7
Q

concordance

A

agreement
monozygotic twins have much higher

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8
Q

deep brain stimulation

A
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9
Q

delusions

A

false ideas and beliefs

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10
Q

differential diagnosis

A
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11
Q

DISC1

A

disrupted in schizophrenia 1
gene controls rate of generation of new neurons and dendritic spine profuction

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12
Q

dopamine hypothesis of schizophrenia

A

excess activity at dopamine synapses

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13
Q

electroconvulsive therapy (ECT)

A

electrically induced seizure used for treatment of severe depression

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14
Q

folic acid

A

may relieve depressive symptoms, ingredient in mood stabilizers

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15
Q

glutamate hypothesis of schizophrenia

A

deficient activity at glutamate synapses

dopamine inhibits glutamate release or glutamate stimulates neurons that inhibit dopamine release

Increased dopamine thus produces the same effects as decreased glutamate

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16
Q

hallucinations

A

false sensory sensations

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17
Q

lithium

A

salt that stabilizes mood and prevents relapse in mania or depression

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18
Q

major depression

A

feeling sad and helpless everyday for weeks and includes:

-Little energy
–Feelings of worthlessness
–Suicidal thoughts
–Feelings of hopelessness
–Difficulty sleeping
–Difficulty concentrating
–Little pleasure

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19
Q

mania

A
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20
Q

mesolimbocortical system

A

set of neurons that project from midbrain to limbic system - where antipsychotics have positive effects

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21
Q

methadone

A
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22
Q

monamine oxidase inhibitors (MAOIs)

A

block enzyme that eats serotonin -> more transmitters in presynaptic terminal that can be released

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23
Q

negative symptom

A

take away from experience
absent emotion, speech, and socialization

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24
Q

neurodevelopmental hypothesis

A

abnormalities in prenatal or neonatal development of nervous system leads to minor brain abnormalities and major abnormalities in behavior
result from genetics
environment aggravate

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25
nucleus accumbens
motivation
26
phencyclidine (PCP)
support glutamate hypothesis Low doses produce intoxication and slurred speech –Larger doses produce positive and negative symptoms –Produce little psychotic responses in preadolescents; produce relapse in people with prior schizophrenia
27
phenothiazines
28
positive symptoms
add to experience; behaviors that should not be there hallucinations, delusions, disorganized speech and behavior
29
schizophrenia
deteriorating ability to function in everyday life for at least six mos. and at least two of the following: –Hallucinations: i.e., “hearing voices” –Delusions: unjustifiable beliefs –Disorganized speech –Grossly disorganized behavior –Weak or absent signs of emotion, speech, and socialization
30
seasonal affective disorder (SAD) treatment?
form of depression that regularly occurs in a particular season very bright light - regulating circadian rhythm
31
season-of-birth effect
people born in winter have a slightly greater probability of developing schizophrenia could be because illnesses are more common and nutrition
32
second-generation antipsychotics
seldom cause movement problems more effective at treating negative symptoms less effect on dopamine D2 receptors; more on serotonin type 5-HT2
33
selective serotonin reuptake inhibitors (SSRIs)
blocking reuptake of serotonin
34
self-stimulation of the brain
35
serotonin norepinephrine reuptake inhibitors (SNRIs)
block reuptake of serotonin and norepinephrine
36
substance-induced psychotic disorder
hallucinations and delusions resulting from repeated large doses of amphetamines, methamphetamines, or cocaine
37
tardive dyskinesia
main late onset condition among the Antipsychotics. These are involuntary movements, mainly of the tongue and mouth with twisting of the tongue, chewing, and grimacing movements of the face.
38
tricyclics
block transporter that reabsorb serotonin, dopamine, and norepinephrine into presynaptic neuron after release
39
(MD) What is a more reliable symptom that increased sadness?
absence of happiness
40
After age 14, ajor depression is more common in
women
41
What increases risk of major depression?
Risk is elevated among relatives of people with early-onset depression
42
What gene has been identified in causing major depression?
one that controls the serotonin transporter gene controls the ability of the axon to reabsorb the neurotransmitter after release
43
What disease has been linked to depression/schizophrenia?
Borna
44
what are side effects of tricyclics? why?
drowsiness, dry mouth, difficulty urinating, heart irregularities block histamine, acetylcholine receptors, and some sodium channels
45
which antidepressant drugs are prescribed if SSRIs and tricyclics are not effective?
MAOIs
46
Which antidepressants have the same effect as tricyclics but less side effects?
SSRIs
47
herb often used as treatment of depression
St Johns Wort
48
BDNF
brain-derived neurotrophic factor; important for synaptic activity
49
Prolonged used of antidepressants increases _________ production
BDNF
50
Drugs work better for ________ than psychotherapy
dysthymia: long term unhappy mood
51
side effect of ECT
memory loss
52
lifelong trait of people that are depressed:
sleep pattern disruption; awaken early and are unable to get back to sleep
53
What is the quickest method of relieving depression? What is a more practical solution?
a night of total sleep deprivation benefit is brief, and increased sensitivity to pain go to sleep earlier
54
Exercise recommended for depression why?
regular, non-strenuous increased neurogenesis & BDNF decrease stress hormones
55
unipolar disorder
alternating states of normality and depression
56
bipolar I
57
bipolar II
58
most people suffering from depression have decreased activity in _____ hemisphere & increased activity in the ______ hemisphere
left; right
59
What are the main symptoms of schizophrenia?
delusions, hallucinations, disorganized speech, disorganized behavior, weak emotion/speech/socialization
60
the older age of the _____ at birth the more likely they are to have schizophrenia
father
61
for ____zygotic schizophrenic twins there is a 50% concordance
mono
62
childhood infections like toxoplasma gondii lead to some schizophrenic symptoms. What animal does it reproduce in and are to be owned in shildhood by schizophrenics>
cat
63
mid brain abnormalities and schizophrenia
less than average gray matter & larger ventricles deficits in left temporal and frontal areas thalamus is smaller
64
what drugs are involved with substance-induced psychotic disorder
cocaine, amphetamine, and LSD - increase activity in dopamine receptors
65
schizophrenics have ____ as many D2 receptors
twice
66
what drug psychosis is similar to schizophrenia
PCP
67
second generation (atypical) antipsychotics
alleviate schizophrenia with no movement issues stronger effects on D4 and serotonin receptors more effective than typical