Mood Stabilising Drugs

Question 1

What is the mode of action of lithium?

Answer 1

May block phosphatidylinositol pathway or inhibit glycogen synthase kinase 3 beta

Question 2

What are some side effects of lithium?

Answer 2

dry mouth/odd taste
polyuria & polydipsia
tremor
hypothyroidism
long term reduced renal function
nephrogenic diabetes inspidus
weight gain

Question 3

what are some toxic effects of lithium?

Answer 3

vomiting
diarrhoea
ataxia/course tremor
drowsiness
convulsions
coma

Question 4

What is the mechanism of action of mood stabilisers?

Answer 4

unclear

possibly blocking overactive pathways

Question 5

name some mood stabilisers

Answer 5

Valproic acid
lamotrigine
carbamazepine

Question 6

What are some side effects of valporate?

Answer 6

Teratogenic (neural tube defects)
drowsiness
ataxia
cardiovascular events
induces liver enzymes

Question 7

What are some side effects of carbamazepine?

Answer 7

drowsiness
ataxia
carduovascular effects
induces liver enzymes

Question 8

what is a side effect of lamotrigine?

Answer 8

stevens-Johnson syndrome

Question 9

what antipsychotics may act as mood stabilisers?

Answer 9

quetiapine
aripiprazole
olanzapine
lurasidone

Question 10

what is the mode of action of antipsychotics?

Answer 10

dopamine antagonism and serotonin antagonism