More Big Resp/Cardio diseases Flashcards
(86 cards)
What is hypertension?
High blood pressure
What are some causes of hypertension?
Primary hypertension - idiopathic
Secondary hypertension - has a known cause.
Chronic renal infection Polycystic kidney disease Renal artery stenosis Cushing's preeclampsia Drug induced by NSAIDs/oral contraceptive Sleep apnoea Coarctation of the aorta.
What are the risk factors for hypertension?
Genetics Diet Diabetes Obesity Exercise Contraceptives Stress Afro-carribean Age Low birth weight
What are the symptoms for hypertension?
Often there are no symptoms - incidental finding to another condition.
Diet Diabetes Medications Stress Family history Exercise
Upon examination of an individual with suspected hypertension what would be found?
Tar staining Hypercholesterolaemia Xanthalasma Corneal arcus End organ damage Retinopathy Proteinuria Left ventricular hypertrophy Radiofemoral delay Palpable kidneys
What investigations aid the diagnosis of hypertension?
Measure blood pressure using a sphygmomanometer.
ABPM or HBPM
ECG- to look fo cause of hypertension
Urine analysis - to check kidney function
What are the values of stage 1 hypertension?
Clinical = 140/90
ABPM=135/85
What are the values of stage 2 hypertension?
Clinical = 160/100 ABPM= 150/95
What are the values of severe hypertension?
Systolic= >180 OR Diastolic= >110
What is the available treatment for hypertension?
<55yrs old:
1- ACE inhibitor or ARB
2- Add thiazide like diuretic
> 55yrs, Afro-carribean, women of child bearing age:
1- Ca2+ channel blocker
2- Add thiazide like diuretic
All:
3- CCB + ACEI/ARB + Thiazide like diuretic
4- <4.5mmol/L give spironolactone
>4.5mmol/L give higher dose Thiazide like diuretic.
Specialist drugs: Alpha adrenoreceptor agonist
Centrally acting agents
Vasoldilators
What are some examples of ACEIs?
Ramipril
What are some examples of Thiazide like diuretics?
Indapamide
Clortalidone
What are some examples of CCBs?
Felodipine
Diltiazem
Verapamil
What are some examples of angiotensin II antagonists (ARBs)?
Losartan
Valsartan
What are some complications of hypertension?
Atheroma Stroke Haemorrhage MI Left ventricular failure Retinopathy
Puts more strain on organs.
What is Marfan’s syndrome?
A genetic disorder that affects the body’s connective tissue.
What causes Marfan’s syndrome?
Autosomal dominant inheritance.
Mutation to 15q21 in fibrillin-1 gene causing abnormal or absent fibrin in connective tissue.
What are the symptoms of Marfan’s disease?
Cardiac - chest pain murmur palpitations Aortic dilation Mitral valve prolapse
Pulmonary - Pneumothorax
Dyspnoea
Eyes- Ectopia lentis
Bad vision
Skeletal - Tall stature Long thin limbs Scoliosis Kyphosis Funnel or pigeon chest Flat feet Roll in on their ankles High palate Thumb sticks out when they make a fist. Stretch marks Fatigue
What would be seen on the examination of an individual with suspected Marfan’s?
12 systemic features each given a score
If patient score 7 or above then it is Marfan’s.
Systemic features are: Face Mitral valve prolapse Pneumothorax Dural ectasia Scoliosis/kyphosis Pectus deformity Striae Myopia Ankle deformity Flat feet Upper limbs exceed height Thumb Wrist Reduced elbow extension.
What investigations are used to aid the diagnosis of Marfan’s?
ECHO - assess cardiac involvement MRI - assess lumbar spine Pelvic x-ray Chets x-ray Genetic test for fibrillin-1 mutation.
What is the treatment available for Marfan’s?
Annual ECHO to monitor heart.
Prophyllactive aortic surgery
Beta Blockers
ARBs.
What is Stroke?
Temporary occlusion of the blood supply to the brain causing loss of function. It last longer than 24hours.
TIA (transient ischaemic attack) lasts less than 24hours.
What are the causes of stroke?
Haemorrhage - 15%
Ischaemia - 85%
What are the risk factors for stroke?
Male Increasing age Atrial fibrillation Diabetes Smoking Hypertension Hypercholesterolaemia