MORPHOLOGIC ABNORMALITIES OF LEUKOCYTES

Question 1

characterized by granulocytes (monocyte and lymphocyte) with large darkly staining metachromatic cytoplasm granules

Answer 1

ALDER-REILY ANOMALY

Question 2

ALDER REILY ANOMALY - autosomal dominant or autosomal recessive

Answer 2

AUTOSOMAL RECESSIVE

Question 3

granulation, partially digested mucopolysaccharide

Answer 3

REILLY BODIES

Question 4

prominent dark granulation, either fine or heavy = can be observe in band and segmented neutrophil or monocytes

Answer 4

TOXIC GRANULATION

Question 5

represents an increase in acid mucosubstance with azurophilic (primary) granules

Answer 5

peroxidase positive

Question 6

more than five lobes or nuclear segmentation

Answer 6

hypersegmentation

Question 7

hypersegmentation is associated with deficiencies in what

Answer 7

Vit. B12 and Folic Acid

Question 8

Hypersegmentation - Autosomal dominant or autosomal recessive

Answer 8

autosomal dominant

Question 9

decrease nuclear segmentation

Answer 9

Pelger-Huet Anomaly

Question 10

Pelger-Huet Anomaly -Autosomal dominant or autosomal recessive

Answer 10

Autosomal dominant

Question 11

Shape of nuclei of Pelger-Huet Anomaly

Answer 11

round, ovoid, or peanut

Question 12

Pelger-Huet Anomaly is a result from a mutation of what gene

Answer 12

lamin B-receptor gene

Question 13

TRUE or FALSE - Neutrophils functions normally in Pelger-Huet Anomaly

Answer 13

TRUE

Question 14

nuclear chromatin condenses, segments disappear, dark staining spheres, apoptotic nucleus, dying neutrophils

Answer 14

Pyknotic Nucleus

Question 15

spectacle-like (pince-nez) morphology is found in what

Answer 15

Pelger-Huet Anomaly

Question 16

light blue, sharply define crescent or round shape inclusion, giant platelet, usually single dohle-like body inclusion, but may be multiple

Answer 16

May Hegglin Anomaly

Question 17

large hypogranular platelets and thrombocytopenia

Answer 17

May Hegglin Anomaly

Question 18

seen near the periphery of the cytoplasm

Answer 18

Dohle Bodies

Question 19

Dohle Bodies represents aggregates of what

Answer 19

Rough Endoplasmic Reticulum (RNA)

Question 20

intracytoplasmic pale blue or elongated inclusion located close to cellular membranes

Answer 20

Dohle Bodies

Question 21

group of more than 50 inherited enzyme deficiencies resulting from mutations in genes that code for the production of lysosomal enzyme

Answer 21

Lysosomal Storage Disease

Question 22

flawed degradation of phagocytized material and buildup of undigested substrates within lysosomes

Answer 22

Lysosomal Storage Disease

Question 23

AKA Barr Body/X or Sex Chromatin

Answer 23

Pyknotic Nucleus

Question 24

darkly stained structure in the nucleus most often found in the periphery of the nucleus

Answer 24

Pyknotic Nucleus

Question 25

caused by deficient activity of an enzyme necessary for the degradation of dermatan sulfate, heparan sulfate, keratan sulfate, and/or chondroitin sulfate

Answer 25

Mucopolysaccharisoses

Question 26

B-glucosidase(glucocerebrosidase) si available ot confirm diagnosis

Answer 26

GAUCHER DISEASE

Question 27

GAUCHER DISEASE treatment

Answer 27

enzyme replacement therapy with recombinant glucocerebrosidase

Question 28

Accumulation of FAT ni celular lysosomes of vital organs

Answer 28

NEIMANN-PICK DISEASE

Question 29

NEIMANN-PICK DISEASE is a Recessive mutations in what gene?

Answer 29

SMPD1 gene

Question 30

* Adutl form of Niemann pick disease anchdronic granulocytic leukemia * Histiocytes filed with LIPID RICH GRANULES * BLUE GREEN with Polychrome stain suchsa Giemsa or Wright Stain

Answer 30

SEA BLUE HISTIOCYTES

Question 31

hyper segmentation is often associated with deficiency of

Answer 31

Vit. B12 and folic acid

Question 32

associated with infectious states such as burns, malignant disorders,or as a result of drug therapy

Answer 32

toxic granulation

Question 33

WBC AFFECTED IN TOXIC GRANULATION

Answer 33

neutrophils

Question 34

WBC AFFECTED IN ARA

Answer 34

neutrophils, monocytes, lymphocytes

Question 35

Toxic granulation or ARA associated with neutrophilia with left shift

Answer 35

Toxic Granulation

Question 36

toxic Granulation or ARA not associated with dohle bodies

Answer 36

ARA

Question 37

difference between PHA and myelocytes/metamyelocytes

Answer 37

PHA cell size smaller PHA n:c ratio is lower PHA chromatic is darker, more coarse,more densely clumped PHA have colorless cytoplasm Myelocytes have cytoplasm basophilia and neutrophilic left shift

Question 38

Niemann-Pick Disease is positive in what stain

Answer 38

sudan black b, oil red o

Question 39

macrophage with lipid filled lysosomes that appears as small vacuoles; nucleus is eccentric

Answer 39

Foam cells

Question 40

Gaucher's Diesease is positive in what stain

Answer 40

PAS, trichrome, aldehyde fuchsin, acid phosphatase

Question 41

auer rods form cluster

Answer 41

faggots cells

Question 42

suggestive of promyelocytic leukemia

Answer 42

faggots cells

Question 43

may hegglin anomaly is mutation in what gene

Answer 43

MYH9 gene on chromosome 22q12-13