morphology

Question 1

in ovary

Sertoli or Leydig cells interspersed with stroma.

Answer 1

Well-differentiated: Sertoli-leydig Cell Tumors

Question 2

in ovary

sarcomatous pattern w disorderly disposition of epi cell cords & Leydig cells may be absent.

Answer 2

Poorly-differentiated: Sertoli-leydig Cell Tumors

Question 3

• Sharply circumscribed, discrete, round, firm, gray-white tumors
• whorled pattern of smooth mm. bundles resembling the uninvolved myometrium.
• oval nucleus & long, slender bipolar cytoplasmic processes.
• Scarce mitotic figures
• yellow-brown-red areas of softening.

Answer 3

Uterine Leiomyoma (fibroids)

Question 4

• Exophytic, papillary architecture

- Prominent koilocytic atypia

Answer 4

Warty Carcinoma (of vulva)

Question 5

Larger cysts near the fimbriated end of the tube or in the broad ligaments
 lined with benign, serous (tubal type) epi

Answer 5

Hydatids of Morgagni

Question 6

in ovary

-in the ovarian stroma composed of both fibroblasts & plump spindle cells w lipid droplets.

Answer 6

ovarian fibrothecoma

Question 7

in ovary

• cells that look like granulosa cells of a developing ovarian follicle.
• yellow from stored lipids
• call-exner bodies

Answer 7

granulosa cell tumors of ovary

-Call-Exner bodies: small, distinct, gland-like structures filled with acidophilic material.

Question 8

thinning of epidermis: parchment paper

Answer 8

lichen sclerosis leukoplakia

Question 9

in ovary
 Unilateral tumors
 Large vesicular cells with clear cytoplasm (like seminoma).
 Grow in sheets or cords.
 Scant fibrous stroma infiltrated by mature lymphocytes +/- granulomas

Answer 9

dysgerminoma

Question 10

• placental infarcts and syncytial knots
• retroplacental hematomas
• abn decidual vessels

Answer 10

preeclampsia placenta

Question 11

proliferating, back-to-back, branching glands w nuclear atypia

Answer 11

atypical endometrial hyperplasia

Question 12

prolif of glandular epi w lg, hyperchrimatic nuclei and dark appearance of glands

Answer 12

adenocarcinoma of cervix

Question 13

in ovary
o Extensive mucinous ascites.
o Cystic epi implants on peritoneal surfaces, adhesions, and frequent involvement of the ovaries

Answer 13

Pseudomyxoma Peritonei

Question 14

cowdry bodies

Answer 14

HSV

Question 15

intraepithelial malignancy w cells larger than surrounding keratinocytes

Answer 15

extramammary paget dis

Question 16

Eosinophilic epi metaplasia ~ menstrual epi BUT lacks progesterone dependent morphologic features (glandular secretory changes, stromal predecidualization) bc the corpus luteum does not develop.

Answer 16

Anovulatory Cycle

Question 17

Delicate, friable mass of thin walled, translucent, cystic, grapelike structures with swollen, edematous (hydropic) villi.

Answer 17

hydatidiform mole

Question 18

glandular and squamous epi of cervix

Answer 18

adenosquamous carcinoma of cervix

Question 19

chocolate cysts/endometriomas:

Answer 19

endometriosis

-3-5cm cystic masses filled w brown fluid (hemosiderin deposits) from previous hemorrhage

Question 20

 Only a fraction of the villi are enlarged and edematous.

 Trophoblastic hyperplasia is focal and less marked

Answer 20

Partial Mole

Question 21

in ovary

o Extraembryonic differentiation of malignant germ cells of placental origin.

Answer 21

choriocarcinoma

Question 22

• Surface epi: viral cytopathic changes (koilocytic atypia).

- Nuclear enlargement, hyperchromasia, cytoplasmic nuclear halo

Answer 22

Condyloma Acuminatum (genital wart)

Question 23

Cells small w oval nuclei and cytoplasmic protrusions (tennis racket shape).
cells (often mistaken for inflamm. Polyps)

Answer 23

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)

Question 24

in ovary
 Glomerulus-like structure with a central blood vessel enveloped by tumor cells in a space lined by tumor cells (schiller-duval body).

Answer 24

yolk sac tumor

Question 25

in ovary  Solid + cystic areas of growth.  Epithelium consists of tubular glands resembling endometrium

Answer 25

endometriod tumors of ovary (mullerian epithelium)

Question 26

inreased gland:stroma ratio | -back-to-back w maybe some intervening stroma

Answer 26

nonatypical endometrial hyperplasia

Question 27

cysts lined w bright yellow tissue containing granulosa cells

Answer 27

luteal cysts (corpora lutea)

Question 28

o Bulky, polypoid. o May protrude thru the cervical os. o Usually consist of adenocarcinoma (glandular) mixed with malignant mesenchymal elements (mm, cartilage, bone, etc).

Answer 28

Malignant Mixed Mullerian Tumors (MMMTS) (carcinosarcomas)

Question 29

o Soft, fleshy, yellow-white tumor. o Large, pale areas of necrosis + extensive hemorrhage. o Invades underlying myometrium, often penetrating blood vessels.

Answer 29

choriocarcinoma

Question 30

-Discrete white (hyperkeratotic) or slightly raised, pigmented lesion w Epidermal thickening

Answer 30

VIN (vulvar intraepithelial neoplasia)

Question 31

in ovary  Solid grey to golden brown.  Grossly resemble granulosa cell tumors.

Answer 31

Sertoli-leydig Cell Tumors

Question 32

in ovary o Small, multilocular tumors with simple papillary processes. o Pronounced proliferation of the fibrous stroma under the columnar epi

Answer 32

cystadenofibroma

Question 33

- Exophytic or indurated and ulcerated - Small tightly packed basaloid cells - Foci of central necrosis

Answer 33

Basaloid Carcinoma (of vulva)

Question 34

~small cell carcinoma of lung but on cervix

Answer 34

neuroendocrine carcinoma of cervix

Question 35

in ovary  Complex patterns of growth.  Widespread infiltration of underlying stroma.  Marked nuclear atypia, pleomorphism, and multinucleation  Increased mitotic activity with atypical mitosis.  Cysts are lined with columnar epi.  66% are b/l.  Often involve the surface of the ovary

Answer 35

high grade serous tumors of ovary (mullerian epithelium)

Question 36

Multinucleated squamous cells with eosinophilic to basophilic viral inclusions w a 'ground glass' appearance (viral cytopathic effect)

Answer 36

HSV

Question 37

red glandular epithelium in vagina

Answer 37

vaginal adenosis

Question 38

- invade teh uterine wall or project into the uterine lumen | - nuclear atypia w great mitotic index

Answer 38

Leiomyosarcoma

Question 39

plasma cell on bx*

Answer 39

chronic endometritis

Question 40

degeneration of basal cells, hyperkeratosis, sclerotic changes

Answer 40

lichen sclerosis leukoplakia

Question 41

in ovary - tumor w well-diff fibroblasts w scant interspersed collagenous stroma - glistening intact ovarian serosa

Answer 41

ovarian fibroma

Question 42

in ovary | -in the ovarian stroma composed of plump spindle cells with lipid droplets

Answer 42

ovarian thecoma

Question 43

in ovary  Multiloculated tumors willed with sticky, gelatinous fluid rich in glycoproteins.  Lined by tall, columnar epi with apical mucin, lacking cilia.  Most show gastric or intestinal type differentiation.

Answer 43

-malignant mucinous tumors of ovary (mullerian epithelium)

Question 44

o Nests + tongues of malignant squamous epi. | o Invade the underlying cervical stroma

Answer 44

scc of cervix

Question 45

in ovary | o Normal stroma with nests of neoplastic epi cells resemble urothelium with mucinous glands in the ctr

Answer 45

Transitional Cell Tumors (Brenner Tumors) of ovary (mullerian epithelium)

Question 46

in ovary  Smooth glistening cyst wall with no epi thickening or with small papillary projections.  Cysts are lined with columnar epi with lots of cilia.

Answer 46

benign serous tumors of ovary (mullerian epithelium)

Question 47

Theca cells prolif and the perifollicular zone expands in response to gonadotropins released during preg

Answer 47

Theca Lutein Hyperplasia of Pregnancy

Question 48

in ovary  Resembles hypersecretory gestational endometrium.  Solid: cells are arranged in sheets or tubules.  Cystic: cells line the spaces.

Answer 48

clear cell carcinoma of ovary (mullerian epithelium)

Question 49

- cluster of polygonal cellsaround hilar vessels - lg, lipid laden leydig cells - reinke crystalloids

Answer 49

Hilus Cell tumors (pure Leydig cell tumors)

Question 50

Guarnieri bodies

Answer 50

Molluscum contagiosum (poxvirus)

Question 51

o Stroma appear neoplastic, while the glands appear reactive. o Glands may be hyperplastic, atrophic or functional.

Answer 51

endometrial polyps

Question 52

in ovary | u/l tumor w itestinal tissue that may be functional (5-HT)

Answer 52

Monodermal or Specialized Teratoma of ovary: Ovarian Carcinoid

Question 53

tumor cells Grow as polypoid, rounded, bulky masses = grapelike clusters.

Answer 53

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)

Question 54

 Seen in small, atrophic uteri.  Tumors are large and bulky or invasive into the myometrium.  Papillary growth pattern.  ↑ nuclear atypia

Answer 54

-Type 2 endometrial serous carcinoma

Question 55

in ovary | -unilocular cysts w hair and sebacisou material, teeth, and calcifications in the stratified squamous wall

Answer 55

mature teratoma (benign) of ovary

Question 56

 Marked atypia of the basal layer of the squamous epi buut Normal differentiation of the superficial layers  Nests and tongues of malignant squamous epi  Prominent central keratin pearls

Answer 56

keratinizing scc of vulva

Question 57

Loose, fibromyxomatous stroma covered by mucus secreting endocervical glands +/- inflamm.

Answer 57

endocervical polyps

Question 58

t cells: band-like infiltrate

Answer 58

lichen sclerosis leukoplakia

Question 59

red/blue to yellow/brown nodules on or beneath the mucosa and/or serosal surfaces. (powder burn marks)

Answer 59

endometriosis -from Bleed in response to extrinsic (cyclic) & intrinsic hormonal stimulation → extensive fibrous adhesions between structures = obliteration of pouch of Douglas.

Question 60

in ovary | u/l tumor w mature thyroid tissue that may be functional --> hyperthyroidism

Answer 60

Monodermal or Specialized Teratoma of ovary: Struma Ovarii

Question 61

psammoma bodies (concentric calcifications)

Answer 61

serous tumors of ovary (mullerian epithelium)

Question 62

cyst w clear, serous fluid, lined by gray, glistening mem and outer theca cells

Answer 62

cystic ovaria follicles

Question 63

inovary - Tumor tissue resembles embryonal and immature fetal tissue. - Solid, bulky tumors with a smooth external surface. - May see hair, sebaceous material, cartilage, bone, calcification

Answer 63

immature malignant teratomas of ovary

Question 64

 Grapelike structures = edematous (hydropic) villi)  All/most chorionic villi are enlarged.  Scalloped in shape with central cavitation (cisterns).  Covered by extensive trophoblastic proliferation of the entire villi circumference.

Answer 64

Complete Mole

Question 65

- Tumor cells may be crowded in a cambium layer beneath vaginal epi. - -Or the tumor cells can be within an edematous, loose fribomyxomatous stroma in the deep regions w inflamm.

Answer 65

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)