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Liz's Hematology Module 2 > Morphology in Mature Lymphoid Disorders > Flashcards

Morphology in Mature Lymphoid Disorders Flashcards

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1
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Hairy Cell Leukemia

  • Oval or indented nucleus w/ abundant cytoplasm
  • May have single nucleolus
  • Cytoplasm is irregular and gray-blue w/ delicate hair-like cytoplasmic projections
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2
Q

What cell line is CLL/SLL?

A

B-cell

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3
Q

Describe the clinical presentation of Hairy Cell Leukemia

A
  • Pancytopenia
  • Severely enlarged spleen
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4
Q

The STAT3 gene mutation occurs in which lymphoproliferative disorder?

A

Large Granular Lymphocyte Leukemia

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5
Q

Burkitt Lymphoma “always” involves the ____ ____ but ____ ____ may also be infiltrated

A

Lymph Nodes; bone marrow

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6
Q

What abnormalities indicates a poor prognosis in patients w/ CLL?

A
  • del(11)(q22-23) or del(11) + 12
  • Rapid lymphocyte doubling time (< 12 months)
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7
Q

Describe the clinical presentation of Mycosis Fungoides and Sezary Syndrome

A
  • Neoplasic proliferation of T cells in the skin → itchy, painful rash (pruritus)
  • Circular patterns of baldness, inflammation of hair follicles
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8
Q

Which lymphoproliferative disorder is known to be often present in localized LN involvement

A

Classical Hodgkin Lymphoma

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9
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Mycosis Fungoides and Sezary Syndrome

  • Convoluted and cerebriform nucleus
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10
Q

Which lymphoproliferative disorder is know for a diffuse architecture w/ starry sky pattern?

A

Burkitt Lymphoma

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11
Q

Which lymphoproliferative disorder is known to be Cyclin D1+ ?

A

Mantle Cell Lymphoma

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12
Q

Which lymphoproliferative disorder is known for containing smudge cells?

A

CLL

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13
Q

What is Waldenstrom’s Macroglobulinemia?

A

Malignant lymphoproliferative disorder involving plasma cells (B-cell lineage) that produce monoclonal IgM

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14
Q

Which lymphoproliferative disorder is known to be CD7- and CD8-?

A

Cutaneous T-cell Lymphoma/Mycosis Fungoides

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15
Q

What is the age of onset for Large Granular Lymphocyte Leukemia?

A

Predominantly 45-75 years old

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16
Q

Predominant cell type found in LN paracortex

A

T cells

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17
Q

Which lymphoproliferative disorder is known to have CD11c, CD103+, Cd123+, bright CD20+ immunophenotype?

A

Hairy Cell Leukemia

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18
Q

Which lymphoproliferative disorder is known to be CD45-?

A

Classical Hodgkin Lymphoma

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19
Q

The t(14;18) abnormality is found in which lymphoproliferative disorder?

A

Follicular Lymphoma

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20
Q

Which lymphoproliferative disorder is know for diffuse infiltrates into the skin?

A

Cutaneous T-cell Lymphoma/Mycosis Fungoides

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21
Q

100% proliferation via the Ki67 stain is used w/ which lymphoproliferative disorders?

A

Burkitt Lymphoma

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22
Q

Which lymphoproliferative disorder is know to be bcl2+ ?

A

Follicular Lymphoma

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23
Q

What are the three types of Burkitt Lymphoma?

A
  1. Endemic 2. Sporadic 3. Immunodeficiency-associated
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24
Q

What is the lineage of plasma cells?

A

B-cell line

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25
Diagnostic features of Waldenstrom's Macroglobulinemia
- Hyperviscosity of blood → blurry vision, headache, vertigo, tinnitus, heart failure - Anemia - Cryoglobulinemic purpura ("purple rash") due to hyperviscosity and IgM - Severe clotting disorders
26
What is the age of onset for CLL/SLL?
Median age: 65-70 years old; rare in patients \< 30 years old
27
What cell line is Large granular lymphocyte Leukemia?
T-cell
28
What lymphoproliferative disorder is associated w/ this cell?
Plasma Cell Myeloma - Rouleaux of RBCs on peripheral blood due to paraproteins - Plasma cells → eccentric nucleus, deeply basophilic cytoplasm, perinuclear clear zone (hof)
29
What Ig do mott cells produce?
IgG
30
What is the age of onset for Burkitt Lymphoma?
Median age: 30 years old and mainly children
31
What is the age of onset for Hairy Cell Leukemia?
Median age: 50 years old
32
Diagnostic features of Plasma Cell Myeloma
Punched out bone lesions seen on radiograph
33
What lymphoproliferative disorder is associated w/ this cell?
Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia - Lymphs are mostly mature, monotonous, and have round nuclei w/ clumped chromatin
34
What cell line is Follicular Lymphoma?
B- cell
35
What is the significance of the Ki67 stain?
Indicates rapid proliferation
36
Which lymphoproliferative disorder is known to have sezary cells in the PB?
Cutaneous T-cell Lymphoma/Mycosis Fungoides
37
Which type of Hodgkin Lymphoma is associated w/ the Epstein Barr virus and HIV immunosupression?
Classical Hodgkin Lymphoma
38
What is the immunophenotyping for Waldenstrom's Macroglobulinemia?
CD19+, CD20+, CD24+, Kappa/Lambda light chains
39
Sporadic type of Burkitt Lymphoma - Age of onset - Geographic location - Immunodeficiency status
- Age of onset: median age of 35 years old - Geographic location: U.S. and Europe - Immunodeficiency status: \< 1% of non-Hodgkin lymphomas
40
What cell line is Hariy Cell Leukemia?
B-cell
41
What are each of the inclusions called in a mott/grape cell/morula?
Russell bodies
42
The BRAF-V600E mutation is found in which lymphoproliferative disorder?
Hairy Cell Leukemia
43
What lymphoproliferative disorder is associated w/ this cell?
Prolymphotcytic Leukemia - Relatively large cells w/ one prominent nucleolus which appears to be "punched out" - Intermediate chromatin condensation
44
What are the two types of cells found in Plasma Cell Myeloma?
- Flame cells - Mott cells
45
Immunodeficiency-associated type of Burkitt Lymphoma is associated with...
HIV/AIDs
46
What Ig do flame cells produce?
IgA
47
What is the site of presentation for CLL?
Bone marrow
48
What are the two types of Hodgkin Lymphoma?
1. Classical Hodgkin Lymphoma 2. Nodular Lymphocyte Predominate Hodgkin Lymphoma
49
What cell line is Mycosis Fungoides?
T-cell
50
Treatment options for Waldenstrom's Macroglobulinemia
- Alkylating chemotherapeutic agents - Rituximab (monoclonal Ab against CD20) - IgM removed via plasmaphoresis for rapid (and temporary) improvement of symptoms
51
Which lymphoproliferative disorder is the most common extranodal lymphoma?
Cutaneous T-cell Lymphoma/Mycoides Fungoides
52
What is the age of onset for Mycosis Fungoides?
Elderly
53
What lymphoproliferative disorder is associated w/ this cell?
Burkitt Lymphoma - Accumulation of monotnous medium-sized mature B-cells w/ many vacuoles
54
Predominant cell type found in LN medulla
Plasma cells
55
The t(11;14) abnormality is found in which lymphoproliferative disorder?
Mantle Cell Lymphoma
56
What cell line is Classical Hodgkin Lymphoma?
B-cell
57
Which lymphoproliferative disorder is known for containing hairy cells?
Hairy Cell Leukemia
58
Monoclonal IgG or IgA in serum or urine, rouleaux, and bone lesions are found in which lymphoproliferative disorder?
Plasma Cell Myeloma/Multiple Myeloma
59
In CLL, what B-cell abnormality is found in the peripheral blood?
\> 5 × 109/L B-cells sustained for 3 months
60
What cell line is Plasma Cell Myeloma/Multiple Myeloma?
B-cell
61
Which lymphoproliferative disorder is know to have medium sized cells w/ many vacuoles?
Burkitt Lymphoma
62
What cell line is Burkitt Lymphoma?
B-cell
63
What genetic abnormality indicates a good prognosis in patients w/ CLL?
del(13)(q14.3)
64
Endemic type of Burkitt Lymphoma - Age of onset - Geographic location - Immunodeficiency status
- Age of onset: Peak incidence b/w 4-7 years old - Geographic location: Equatorial Africa - Immunodeficiency status: 50x higher incidence than U.S.
65
What is the age of onset for Follicular Lymphoma?
Median age: 60 years old
66
What was the historic cytochemical stain that was used to confirm the presence of hairy cells?
TRAP
67
What are smudge cells?
Broken up B-cells
68
The t(8;14) and MYC oncogene is found in which lymphorproliferative disorder?
Burkitt Lymphoma
69
Which lymphoproliferative disorder is known to have Reed-Sternberg and Hodgkin cells?
Classical Hodgkin Lymphoma
70
What lymphoproliferative disorder is associated w/ this cell?
Plasma Cell Myeloma - Rouleaux of RBCs on peripheral blood due to paraproteins - Plasma cells → eccentric nucleus, deeply basophilic cytoplasm, perinuclear clear zone (hof)
71
What is the age of onset for Mantle Cell Leukemia?
Median age: 60 years old
72
Predominant cell type found in LN follicles
B cells
73
T/F, SLL often demonstrates cytopenias
False, CLL does - There are no cytopenias in SLL b/c there is no BM infiltration
74
In SLL, what B-cell abnormality is seen in the peripheral blood?
\< 5.0 × 109/L B-cells
75
What lymphoproliferative disorder is associated w/ this cell?
Hodgkin Lymphoma - Reed-Sternberg cells found in low numbers in the LNs in a reactive background
76
Which lymphoproliferative disorder is known to be CD4-, CD8+, CD57+, CD16+, TIA1+, and have Granzyme B?
Large Granular Lymphocyte Leukemia
77
What cell line is Mantle Cell Lymphoma?
B-cell
78
Describe the clinical presentation of Prolymphocytic Leukemia
- Absolute lymphocytosis (\> 100 × 109/L) - Anemia - Thrombocytopenia - B or T cell
79
Which lymphoproliferative disorder is know for plasma cell infiltrates in the BM w/ \>30% of cellularity?
Plasma Cell Myeloma/Multiple Myeloma
80
Which lymphoproliferative disorder is the most common non-Hodgkin?
Follicular Lymphoma
81
\_\_\_\_ changes and ____ changes are caused by ____ and ____ changes
Morphologic; Functional; Genetic; Epigenetic
82
What is the site of presentation for SLL?
Lymph node
83
The cortex of a normal LN consists of...
Contains the follicles/germinal centers

Liz's Hematology Module 2 (13 decks)

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