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Motility Drugs Flashcards

(96 cards)

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1
Q

Class of Botulism Toxin

A

Neuromuscular blocker, Toxin

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2
Q

Common Name of Botulism Toxin

A

Botox

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3
Q

MOA of Botox/Botulism Toxin

A

Inhibits ACh release from the presynaptic surface – reducing neuromuscular transmission/muscular activity

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4
Q

GI Indication for Botox

A

LES/Internal/Anal Sphincter Achalasia

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5
Q

ADR for Botox

A

Dysuria, Dsphagia, Constipation, headache, fever, sweating

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6
Q

Class of Promethizine

A

phenothiazines, antiemetic

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7
Q

Common Name of Promethizine

A

Phenergan

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8
Q

MOA of Promethizine

A

Acts on the CNS, muscarininc blocking

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9
Q

GI Indication for Promethizine

A

vomiting

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10
Q

ADR for Promethizine

A

drowsiness, confusion, anxiety

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11
Q

Class of Prochlorperazine

A

antiemetic, phenothiazines

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12
Q

Common Name of Prochlorperazine

A

Compazine

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13
Q

MOA of Prochlorperazine

A

Acts on the CNS, D2 dopamine receptor antagonist

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14
Q

GI Indication for Prochlorperazine

A

Vomiting, nausea, vertigo

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15
Q

ADR for Prochlorperazine

A

drowsiness, confusion, anxiety

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16
Q

Class of Metoclopramide

A

Antiemetic, dopamine antagonist

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17
Q

Class of Ondansetron

A

Antiemetic

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18
Q

Class of Nifedipine

A

Calcium Channel Blocker (CCB)

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19
Q

Class of Neostigmine

A

Acetylcholinesterase Inhibitor

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20
Q

Class of Verapamil

A

Calcium Channel Blocker (CCB)

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21
Q

Common Name of Metoclopramide

A

Reglan

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22
Q

Common Name of Ondansetron

A

Zofran

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23
Q

Common Name of Nifedipine

A

Nifedicep

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24
Q

Common Name of Neostigmine

A

Prostigmine

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25
Common Name of Verapamil
calan
26
MOA of Metoclopramide
Acts on CNS and ANS, stimulates gastric peristalsis to facilitate gastric emptying, tightens LES to prevent reflux
27
MOA of Ondansetron
5-HT3 seretonin receptor antagonist, peripherally and at vagal nerve terminals
28
MOA of Nifedipine
inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle
29
MOA of Neostigmine
prevents ACh destruction by Aceytlcholinesteras
30
MOA of Verapamil
inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle
31
GI Indication for Metoclopramide
gastroparesis, gastric stasis, vomiting, particularly due to gastric dysmotility
32
GI Indication for Ondansetron
nausea and vomiting in pt on chemo
33
GI Indication for Nifedipine
Esophageal and internal anal sphincter achalasia
34
GI Indication for Neostigmine
increases bowel motility in the LGI
35
GI Indication for Verapamil
Esophageal and internal anal sphincter achalasia
36
ADR for Metoclopramide
restlessness, functional dystonia, tardive dyskinesia
37
ADR for Ondansetron
headache, malaise, fatigue, constipation
38
ADR for Nifedipine
flushing, edema, dizziness, headache, nausea, heartburn, constipation
39
ADR for Neostigmine
arrythmia,cardiac arrest, tachycardia, convolsion, dizziness, diarrhea, dysphagia, flatulence, hyperperistalsis, nausea
40
ADR for Verapamil
flushing, edema, dizziness, headache, nausea, heartburn, constipation
41
CCBs
Verapamil, Nifedipine
42
antiemetic's
``` Promethizine (Phenergan) Prochlorperazine (Compazine) Metoclopramide (Reglan) Diphenhydramine (Benadryl) Ondansetron (Zofran) ```
43
Class of Diphenhydramine
antiemetic. Antihistamines, ethanolamines
44
Class of Maclizine
Antiemetic, antihistamine
45
Class of Bethanechol
Cholinergic Agonist
46
Class of Al-Mg Antacids
Antacids
47
Class of Cimetidine
H2 receptor antagonist, antacid
48
Class of Ranitidine
H2 receptor antagonist, antacid
49
Class of Misoprostil
PGE2 receptor stimulator, cytoprotective agen
50
Class of Sucralfate
cytoprotective agent,
51
Class of Omeprazole
PPI, general GI wonderdrug
52
Class of Lansoprazole
PPI, general GI wonderdrug
53
Class of Esomeprazole
PPI, general GI wonderdrug
54
Common Name of Diphenhydramine
Benadryl
55
Common Name of Bethanechol
Urecholine
56
Common Name of Al-Mg Antacids
Mylanta, Maalox is actually Ca2CO3
57
Common Name of Cimetidine
Tagamet
58
Common Name of Ranitidine
(Zantac)
59
Common Name of Misoprostil
Cytotec
60
Common Name of Sucralfate
(Carafate)
61
Common Name of Omeprazole
(Prilosec)
62
Common Name of Lansoprazole
(Prevacid)
63
MOA of Diphenhydramine
Acts on the CNS, an H1 histamine receptor antagonist
64
MOA of Maclizine
central anticholinergic action by blocking chemoreceptor trigger zone; decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways
65
MOA of Bethanechol
stimulation of the parasympathetic nervous system, stimulates gastric motility, increases gastric tone, stimulates peristalsis
66
MOA of Al-Mg Antacids
neutralizes intestinal acid, forms Al (Cl)3 salt + H2O or MgCl2
67
MOA of Cimetidine
Competitive inhibition of histamine at H2 receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced
68
MOA of Ranitidine
Competitive inhibition of histamine at H2 receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced
69
MOA of Misoprostil
stimulates PGE2 receptors, resulting in inhibition of acid secretion and stimulation of mucus and bicarbonate production.
70
MOA of Sucralfate
binds with positively charged protein exudates to form a viscous paste that creates a protective coating in the stomach. Does not alter stomach flora by changing chemical composition.
71
MOA of Omeprazole
selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.
72
MOA of Lansoprazole
selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.
73
MOA of Esomeprazole
selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.
74
GI Indication for Diphenhydramine
vomiting
75
GI Indication for Maclizine
nausea related to vertigo and motion sickness
76
GI Indication for Bethanechol
GERD, to increase UGI motility
77
GI Indication for Al-Mg Antacids
PUD and GERD, mainly sx relief
78
GI Indication for Cimetidine
duodenal and gastric ulcers (speed healing, reduce sx), gastric hypersecretion, GERD, part of H. pylori multidrug therapy
79
GI Indication for Ranitidine
duodenal and gastric ulcers (speed healing, reduce sx), gastric hypersecretion, GERD, part of H. pylori multidrug therapy
80
GI Indication for Misoprostil
prevention of gastric ulcers, especially w NSAID use
81
GI Indication for Sucralfate
short term management of ulcers
82
GI Indication for Omeprazole
GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis
83
GI Indication for Lansoprazole
GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis
84
GI Indication for Esomeprazole
GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis
85
ADR for Diphenhydramine
drowsiness, confusion, anxiety
86
ADR for Maclizine
drowsiness, fatigue, headache, vomiting, blurred vision, anaphylaxis
87
ADR for Bethanechol
hypotension, tachycardia, headache, abdominal cramps, belching, borborygmi, diarrhea, colicky pain, nausea, vomiting
88
ADR for Al-Mg Antacids
Al - constipation, Mg - diarrhea
89
ADR for Cimetidine
diarrhea, nausea, vomiting, anaphylaxis, headache, dizziness, bradycardia, tachycardia (what?!), vasculits, there are more and im done typing
90
ADR for Ranitidine
abdominal discomfort or pain, constipation, diarrhea, nausea, vomiting, agitation, dizziness, headache
91
ADR for Misoprostil
Constipation, dyspepsia, flatulence, nausea, vomiting, headache
92
ADR for Sucralfate
constipation
93
ADR for Omeprazole
abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash
94
ADR for Lansoprazole
abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash
95
ADR for Esomeprazole
abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash
96
Common Name of Esomeprazole
(Nexium)

GI Pharmacology (3 decks)

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