Motor neurone disease Flashcards Preview

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Flashcards in Motor neurone disease Deck (15)
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1
Q

What is motor neurone disease?

A

An untreatable and rapidly progressive neurodegenerative condition

2
Q

What is the most common subtype of MND?

A

Amyotrophic lateral sclerosis

3
Q

What is the average survival time from diagnosis of MND?

A

3 years

4
Q

MND is most common in what population?

A

Caucasian population

5
Q

Describe the clinical presentation of MND

A

Muscle weakness and wasting

Speech, swallow and breathing problems

Focal onset and continuous spread

Cognitive impairment

6
Q

What does MND NOT involve?

A

Sensory symptoms

7
Q

How does amyotrophic lateral sclerosis, a subtype of MND, most often present?

A

LMN signs in the arms and UMN signs in the legs

8
Q

How does progressive muscular atrophy, a subtype of MND, typically present?

A

LMN signs only

Affects distal muscles first

*Best prognosis

9
Q

How does primary lateral sclerosis, a subtype of MND, typically present?

A

UMN signs only

10
Q

How does progressive bulbar palsy, a subtype of MND, typically present?

A

Palsy of the tongue, muscle of mastication and facial muscles

Worst prognosis

11
Q

There is a link between MND/ ALS an which type of dementia?

A

Frontotemporal dementia

12
Q

What investigations can be done for MND?

A

Clinical

EMG

Neuroimaging to rule out other conditions

13
Q

How is MND managed?

A

Nutrition

Ventilation

(supportive)

14
Q

What are the 4 types of MND?

A

Amyotrophic lateral sclerosis

Progressive bulbar palsy

Progressive muscular atrophy

Primary lateral sclerosis

15
Q

Why is the prevalence of MND not much higher than the incidence?

A

Patients don’t survive for very long