Movement, addiction and Sleep Flashcards
(125 cards)
1
Q
4 forms of analgesics
A
-Opium
-Morphine
-Heroin
-Opioids
2
Q
Acetycholine
A
Procuced by a clsuter of neurons in the basal ganglia and the brainstem. Controls every move you make, relases motor neurons through controlling sketal muscles, contributes to the regulation of attention arousal memory
3
Q
ACh for Arousal
A
Important NT for aoursl. two groups: one in pons other in basal forebrain. They produce activation and coritcal desynchrony. There is a third grroup in the medial septum to the hippocampus
4
Q
ACh Recptors”
A
(ionotropic– sitmulated by nicotine)
-Nicontinc receptors between motor neurons and muscles, some clearly some are in the CNS
(Metabotropic – stimulate by muscarine)
-Muscarinric recptors, CNS has both receptors but primairlly muscarinic
5
Q
Adenosine
A
Accumulation of this chemical inhibits neural activity and causes emotional/cognitive effects seen with sleep deprivation.
6
Q
Affinity
A
Drugs vary widely in this, which the readiness by which two moecules attach. For this example, it is between a drug and itss binding site.
7
Q
Agonists
A
Facilitate an NT system
8
Q
Alcohol
A
A CNS depressant and the second most used psychoactive drug. It has two sites of action: Inderaction agonist for GABA receptor and interct antagonist for NMDA recptors. Both cause apoptosis.
9
Q
Amino Acids
A
Most abdunant NT in the CNS. The 3 most common, in the CNS, are:
-Glutamte
-GABA
-Glycine
10
Q
AMPA receptors
A
An ionotropic glutaamate receptor with an affinity for alpha-amino-3-hydroxxy-5-methyl-4-isoxazole propronic acid
11
Q
Amphetamine
A
A CNS Stimulant that has antiastmatic effects, boost alternetness and produces a feeling of confidence. It is a catecholamine agnost, blocking reuptake and directly stimulating the release of dopamine from the presynpatic terminal.
12
Q
Antagonists
A
Repress an NT system
13
Q
Antagonists muscles
A
Moving an arm or leg back and forth requires opposing sets of muscles
14
Q
Anterior corticospinal tract:
A
Ipsilateral fibers direct primary motor cortect directly to target neurons in spinal cord. Controls the core
15
Q
Ascending reticular activating system
A
Wakefulness. Begins from brainstem to hypothalamus to forebrain
16
Q
Basal Ganglia
A
Striatum, caudate nucleus and putamen, globus pallidus, substaintia nigra, subthamalmic nucleus, nucleus accumbens. Functions to orchestrating planned movement, smooth intended motor activity, inhibits unintended motor activity.
17
Q
Behavioral tolerance
A
Tolerance as modifiied by the enviroment – learning and memory
18
Q
Botulin
A
Blocks release of ACh at the neuromuscular junction
19
Q
Causes of Huntingont’s diseasq
A
Repeats of CAG on chromosone 4. Graudal damange in the basal ganglia and the cerebral cortex
20
Q
Causes of parkinson
A
An impairmenet in intitating spontaneous movement in the absence of stimuli to guide the action. Gradual progressive death of neurons, especially in the substantia nigra
21
Q
Cells in cortex
A
Upper motor neurons
22
Q
Cells in ventral horn in spinal cord
A
Lower motor neurons
23
Q
Cocaine
A
A CNS stimulate that causes a sense of euphoria, increased and heightened mental alerntness. Combats effects of hunger a fatigue. It blocks the reuptake of DA,NE 5-HT
24
Q
Cocaine and meth elebate activtity at NE synapses.
A
How do cocaine and meth effect NE synapses
25
Cocaine and Meth elevates activity at DA synapses. Which interferes with Process of reuptake
How do Cocaine/Meth effect Dopamine?
26
Competitve binding
Direct agonists and antagonists act directly on the NT binding site
27
Corticospinal tracts
Paths from cortex to spinal cord. Orginatin in layer V where Betz cells are located. Travels through the corona radiata
28
Curare
Blocks nictonic recptors at the neuromuscular junction
29
Decussation
Anterior Corticopsinal tract -- Crossing over in spinal cord
30
Direct agonists
A drug capable of mimicing the effects of an NT
31
Direct Antagonists
Drugs that can bind with the receptors of a postsynpatic neuron but does not open the ion channel and acts as a receptor blocker
32
Disorders associate with the dysregulation of DA
Parkinsons
-Huntington's
-Schizophrenic disorders
-Addictive disorders
33
Disorders associated with the disregulation of Glutamate:
-Schizophrenia
-Mood Disorders
-Epilepsy
34
Disorders associated with the dysregulation of NE synapses
Depressive disorders
35
Disorders associated with the dysregylatuion of serotonin
-Depressive disorders
-OCD's
-Eating disorders
36
Disorsders assoicates witht eh dysregulate of ACh
-Alzheimers Disease
37
Dopamine
Dopaminergic systems originate in the midbrain. Contributes to voluntary movement, attention and learning as well acting as a reward pathway.
38
Efficacy
Drugs vary widely in this: the ability to produce a desired or intended result.
39
Endocannabinoid
Lipids found in the cannbinoid receptors stimulated by tetrahydrocannbinol. Anandamide, a natural ligand, stimualtes these receptors.
40
Endorphines
Peptides involved in the pain and reward processses.
41
Enzymatic degradation
A specific enzyme changes the structure of the neurotransmitter so it is not recognized by the receptor. For example, acetylcholinesterase is the enzyme that breaks acetylcholine into choline and acetate.
42
Epinephrine
Hormone produced by the adrenal medulla. A NT in the brain and is referred to colloqiually as "Adrenaline."
43
Extrafusal fibers
A skeletal muscle fiber, contracts to shorten a muscle
44
Four major types of glutamate receptors
(Ionotopic)
-NMDA receptor
-AMPA receptor
-Kainate recptor
(Metabotropic)
-Metbotrpic glutamate recptor (At least 8 subtypes)
45
GABA
Simialr to glutamte. Has direct excitatory and inhibitpory effects on axons as well as the ability to raise or lower the threshold of excitation. No need for special rceptors, which indicates that these had a modulating effect before specialized receptors.
46
Gamma-aminobutryic Acid (GABA)
Produced from glutamaitic acid by the action of glutamic acid decarboxylase (GAD)
47
Glutamate
Specifically involved in the creation of synapses, strengthening of synpases-- directly affecting neuroplasticity.
48
Glutamate
Simialr to GABA. Has direct excitatory and inhibitpory effects on axons as well as the ability to raise or lower the threshold of excitation. No need for special rceptors, which indicates that these had a modulating effect before specialized receptors.
49
Glycine
Inhibitory NT in spinal cord and lower portions of the brain stem. Iontropic [Cl-] produces IPSPs. Unsure of how Glycine is produced
50
Glycogen
In times of increased activity, this chemical is converted into fuel and induces prolonged wakefulmess. During the SWS, astrocytes renew their stores of this chemcial
51
Golgi tendon organs
Located in the tendons and also detect tension
52
Histamine for arousal
Cell bodies of histaminergic neurons located in tuberomammilary nucleus of the hypothalamus. Hugh during wakefulness, low during sleep.
53
Homeostatic theory of sleep reguation
Sleep provides rest and recovery. Evidence: Sleep rebound, sleep deprivation. Evidence against: Larger animals do not need more sleep
54
How does Tetanus occur within the body?
The bacteria that causes tetanus releases a chemical that supresses the release of glycine, which causes the muscles to contracl continuously.
55
Hunting's disease
A disease characterized by arm jerks and facial twitches early on. Spreads to other parts of the body and turns into writhing. Interferes with walking, speed and other movements. Loss of ability to learn new movements.
56
Indirect agonist
Drugs can attached to an alternative site and facilitate the opening of an ion channel
57
Indirect antagonist
Drug can attach to one of these alternative sites and prevent ion channels from opening.
58
Inhalation
Average speed of absorption, neither fast or slow.
59
Injection
Fasted speed of aborbdtion, reaches the brain quickly.
60
Intrafusal fibers
A skeletal muscle fiber, detecs changes in muscle length
61
Lateral corticospinal tract
Contralateral fibers that direct a signal from primary motor cortex directly to target neurons in the spinal cord. Controls distal limbs/digits
62
Laterodorsal tegmental nuclei (LDT)
(LDr)One of the relevant groups of ACh neurons that sustains wakefulness through cortical desychnrony (beta waves) projects to thalamus and basal forebrain
63
Locus Coeruleus
A nucleus in the dorsal pons -- most important noradrenergic systms.
64
MDMA (ecstasy)
A form of amphetamine, promotes and feeling of well-being. It's a messy drug, aka a monoamine agonist that causes release of stored dopamine and 5-ht. Has numerous adverse effects
65
Mesocortical system
Projections axons to the prefrontal cortex; excitatroy effect; helps in formation of STm, planning and statergy for problem solving.
66
Mesolimbic Dopaminergic Reward System
"Do it again" Center most active in anticipation of pleasureable events. Signifgant role in the craving or desire for frugs
67
Mesolimbic system (Dopamine)
Projects axons to the nucleus accumbens, amygdala and hippocampus. Rewarding effects and addictive behaviors
68
Monoamines
Single amine group. Consists of Catecholamines (Dopamine, Norephin, epinephrine) and indolamines (serotonin, histamine)
69
Monosyanptic spinal reflex
Hitting the patella with tool. When a muscle streched cord sends a reflexive signal to contract it. The strech reflex is caused by this.
70
Motor unit
Alpha motor neurons, its axon, and the extrafusal fibers that it innervates
71
Muscle spindles
Detect stretch and tension of a muscle
72
NE for Arousal
Important NT for arousal. Activity in the Locus Coeruleus in the dorsal pons gives rise to axons that branch widely releasing NE
73
Neurological
Affets thoughts, motivations and beahviors
74
Neuromsucular junction
A synapse between a motor neuron and a muscle fiber
75
Neuropsychopharamacology
Identify drugs that interactic with the NS to alterbehavior that has been disrypted. To be effective, drugs must reach their sit e of action/
76
Nicotine
A CNS stimulant. Nonsmokers who recieve the same dose experience heightened tension and arousal. Some studies suggest that it activates regions involved in cognition. Receptors exist in many brain regions. In PNS releases releasing epinphine and norepinephrine, The receprs are especially abudnac in the nucleys accumebens and facilitate dopamine release
77
Nitric Oxide
Simple, solubale gas produced by activity of enzymes in neurons. It is a retrograde NT. Used as a messanger thoughout the body and dilates blood vessles in metabollicy actives parts of the brain/
78
NMDA receptors
An exvtiatory ionotropic glutamate receptor with an affinity for N-methyl-D-aspartate.
79
Noncompetitive binding
Some receptors have multiple binding sites. NT binds with one site and other molcles bind with the other
80
Norepinephrine
Noradengric neuronssend input to almost ever part pf the brain. Modulates mood, arousal and vigilance. Contributes to new stimuli and implicated in memory.
81
Oral administartion
Slowest speed of absopotion of a drug
82
Orexin/Hypocretin
Within the lateral hypothalamus, orexin projects to almost every brain region involved in wakefulness and arousal, including the locus coeruleus, raphe nucei, tubermammillary nucleus, and acetylinergioc neurons in the dorsal poins.
83
Oxytocin and Vaopression
Peptides involvded in the regulation of specifc fluids and social relationships
84
Parkinson's disease
Characterized by rigidity, muscle tremors, slow movements and diffiuclty initating physical and mental activity. Additional sympomts: Depression, memory/reasoning defecits and other cogntive effects. Loss of olfaction is an earlysymptom
85
Parkinson's disease treatment
The drug L-dopa is the primary treatment for Parkinson's and is a precursor to dopamine that easily crosses the blood-brain barrier as qwell as surgical neural transplation of doapminergic cells, Additionally, lesioning areas of the basal ganglia and deep brain stimulation
86
Pedunculopontine tegmental nuclei (PPT)
One of the relevant groups of ACh neurons that sustains wakefulness through cortical desychnrony (beta waves) projects to thalamus and basal forebrain
87
Peptides
3-40 Amino acids linked together by peptide bonds. Usually, they are neuromodulators, though some are neurotransmitters.
88
Pharmacodynamic tolerance
Tolerance as a result of exposure to high drug doses
89
Pharmacokinetics
The movement of frugs: the process by which they are absorded, distributed, metaboized and excreted.
90
Pharmacydynamics
What the drugs does the body
91
Pilocarpine
Is an agonist for muscarinic recptors in the CNS
92
Pineal gland
Releases the hormone melatonin, making us sleepy
93
Polysomnograph
A combination of EEG, eve-movement records, EOG, EMG used to record sleep.
94
Pontogeniculooccipital spikes (PGO spikes)
Region of the pons that projects to the lateral geniculate nucleus (of the thalamus) and to the occiptal cortex. Active during dreaming
95
Pre-supplementary motor cortex
Deciding to suppress a response, More complicated task where there is tasks where there is tak switching. Organizes rapid sequences of movements in a specifc order
96
Premotor cortex
Active immediately before moving. Receives info about target, body position, posture. Helps direct movement toward target. Externally guided movements.
97
Proproceptior
A receptor that detects the position or movement of the body
98
Proprooception
The ability to sense the position, orienation, and movement of one's own body
99
Quadriplegia
Spinal cord injury with a severe impact on quality of life. Caused by nerve damage to c3,c4 to c8. Sympoms include: losing control of arms, legs and torse.
100
Raphe Nuclei
Contain most serotonergic neurons. Stimlation of this indcues locomotion and cortical arousal (the faciliation of automatic movements.)
101
REM consolidation
Nondeclarative memory
102
REM Slee[
Mixture of theta/beta activity. Rapid eye movements. Muscles relaxed. Facial twitches. Dreaming
103
Retinohypothalamic tracts
Extend directly from the retin to the SCN can alter the SCN's settings. Resets the internal biological clock.
104
Reuptake
The act of picking up neurons in the synpatic clefy by the presynaptic neuron
105
Scopolamine
Is antagonist for muscarinic recptors
106
Serotonin
INvolved in the regulation of mood, sleep and wakefulness, eating, temperature, sex and agression.
107
Skeletal Muscles
Comprised of extrafusal fibers and intrafusal fibers
108
Slow wave sleep SWS
Synchronized nueral activity and sycnhonized inhibiton of activitit
109
Stage 1 of addiction: Binge/Intoxication stage
A stage in additction. Early, rewarding experiences, such as positive experiences. Begins in the mesolimbic dopaminergic pathway, central amygdala and ventral palladium.
110
Stage 2 of addiction: Withdraw/Negative Affect Stage
After inital stage of addiction, people show withdraw symptoms when drug is no longer available. Is the opposite of the drug's effect/ Extended Amygfala is the central amygdala, bed nucleus of the stria terminais and a portion of the nucleus accumbens shell.
111
Stage 3 of addiction: Preoccupation/Anticipation
This stage leads to relapse and starts the downward spiral. Several drugs have shown to have this effect months/years after usage. Priming effects" Medial preftonal cortex, nucleus accumbens and ventral pallidum. Conditioned cues: basolateral amygdala communication to prefrontal cortex. Compromised hippocampa; functioning.
112
Stychnine
Glycine antagonist, even in small does can causes convulsions, muscle cramps, respiratory problems and even death.
113
Substantia Nigra (Dopamine)
Nigrostriatal system projects axons to the caudate nucleus and the putamen of the basal ganglia.
114
Supplementary motor cortex
Actively immediatly before moving. Self-initated (voluntary) movements. Not so active in movements triggered by external events. Organizes repid sequence of movements in a specific order
115
Supramiasamtic nucleus SCN of the hypothalamus
Circidanin rhymths for sleep/body temperature. Continues when removed from body. Certain retinal ganglion cells respond to light.
116
SWS consolidation
Declarative memeory
117
Therapatic effect:
The target and benefical consequences of the dug
118
Tolerance:
When an individual's reaction to a drug decreases with repeated exposure. Increasingly larger doses are required to achieve the same desired effect.
119
Treatments for quadirlegia
Autologous trnasplantions, proper chemical enviroment require to guide cell developed into the disired type of neuron. Neurorehabilityative therapt.
120
Ventral Tegmental area (Dopamine)
Comprised of the Mesolimbic system and the Mescotical system
121
Ventrolateral preoptic nucleus of the hypothalamus
Projects to the locus coeruleus and raphe nucleus to inhibit arousal. Projects to TMN and pontine to inhbit arousal. Also inhibits the lateral hypothalamus. Promotes sleep and produces GABA/Galanin
122
What causes muscles to contract?
The release of ACh
123
What drugs affect Serotonin?
Prozac and antidepressants.
124
Where are Serotonergic neurons found?
Nine clusts, most of which are found in the raphe nuclei of the midbrain, pons and medulla. Most important clusters are found in the dorsal and medial raphe nuclei.
125
Where at the alpha motor neurons located?
(Efferent fiber) in ventral horn
