MRCP Word Ax COPY Flashcards
(641 cards)
1
Q
Chemo peripheral neuropathy
A
Vincristine Cisplatin
2
Q
Chemo cardiomyopathy
A
Doxorubicin
3
Q
Chemo pulmonary fibrosis
A
Methotrexate
4
Q
Chemo haemorrhagic cystitis
A
Cyclophosamide
5
Q
Anti epileptics safe in pregnancy
A
Levetiracetam Lamotrigine
6
Q
Cereberal Toxoplasmosis Tx
A
Sulfadiazine, Pyrimethamine
7
Q
Histology Barretts Esophagus
A
Columnar metaplasia
8
Q
Electrolyte abnormality worsening digoxin toxicity
A
Hypokalaemia
9
Q
Leukaemia “ Broad based projections” Dry tap TRAP +ve
A
Hairy Cell Leukaemia
10
Q
Worse prognosis RA
A
Female Anaemia 3 months Gradual onset +ve IgM RF +ve CCP
11
Q
Rash with one “herald patch” then spreads
A
Pityrisias Rosea
12
Q
Lewy Body Dementia
A
EPSs Hallucinations Variable sx/GCS
13
Q
Most common Lupus Antibodie
A
ANA
14
Q
Translucent bands bones
A
Osteomalacia
15
Q
Punched Out Osteolytic Lesions
A
Myeloma
16
Q
Nephritis postive for everything high C3, C4, IgM, IgG
A
Lupus Nephritis
17
Q
Neck + shoulder pain, weakness abductor pollicis brevis, pin and needles
A
Cervical Rib
18
Q
Polymyositis Antibody
A
Anti Jo
19
Q
TB Drugs peripheral neuropathy
A
Isoniazid
20
Q
Wernickes vitamin deficiency
A
Thiamine B1
21
Q
Feltys Syndrome
A
Triad : Leucopaenia + RA + Splenomegaly (lympadenopathy, leg ulcers, normocytic anaemia)
22
Q
Tense blistering rash (not affecting rash)
A
Bullous Pemphigoid IgG
23
Q
Farm, haemolytic anaemia, high billrubin, neurology
A
TTP
24
Q
Diabetic meds causing hypos
A
Gliclazide
25
Negatively bifringent crystals joint asp Monosodium Urate Monohydrate
Gout
26
Weakly positive bifringent crystals joint asp Calcium pyrophosphate
Pesudogout
27
Tx Tourettes
Risperidone
28
Palmar crease xanthaoma (pathognomonic)
Broad beta disease
29
Subchondral cysts
OA
30
Periarticular osteopaenia
RA
31
Osteophytes
OA
32
Brown/blue pigmentation
Alkaptonuria Homognetistic oxidase deficiency
33
Cushing K+/pH
Hypokalaemia Alkalosis
34
Conns K+/pH
Hypokalaemia Alkalosis
35
Bloody diarrhoea w/ shistocytes
E coli
36
Main bug causing HUS
E coli
37
Phenylketonuria
Seizures Eczema LD Musty
38
Cancer type most like to cause hypercalcaemia
Squamous Cell
39
Waldenstroms Macroglobulinaemia Ig?
IgM kappa paraprotein
40
Waldenstroms Macroglobulinaemia
HYPERVISCOCITY Cryoglobulinaemia/Raynauds Hepatosplenomegaly Lymphadenopathy
41
Lebers Optic Neuropathy inheritance
Mitochondrial
42
Downs cardiology issues
ASD PDA Fallots Tetralogy Endocardial cushion defect
43
Downs syndrome ax illness
Duodenal Atresia Leukaemia Esophageal fistulae Hypothyroid
44
What is Philadephia chromosome
Due to deletion of long arm 22, usually on 9 Prognosis worse without it Also myelofiborosis, polycythaemia vubra vera
45
Turners syndrome cardiac issues
Coarctation aorta Bicupsid aortic valve
46
Turners hormones
High gonadotrophin Low estrogen
47
Noonans features
male turners absence testicles/crypto orchidism
48
Kleinfelters genetics
47 XXY XXXYY XXYY
49
Kleinfeltoms features
Tall, thin, gynaecomastia, infertility High urinary gonadotrophins
50
Women affected more than male genetics
X linked
51
Mitochondrial inheritance
Maternal transmission V rare Leber optic neuropathy
52
Li Fraumeni Syndrome
Loss of p53 cancer syndrome Breast, brain, sarcoma
53
FAP chromosome
Bowel cancer deletion 5q21
54
Colorectal carcinoma chromosome
18q deletion
55
Haemochromatosis HLA
HLA A3
56
Behcets HLA
B5
57
HLA B27
Ank spod Reiters Psoriatic arthritis Anterior uveitis
58
HLA DR2
MS Pernicious anaemia Nacrolepsy Juvenile diabetes
59
HLA DR3
Coeliac Sjogens Hepatitis Addisons SLE Graves, Hashimotos IDDM MG
60
RA HLA
HLA DR4
61
Coeliac HLA
HLA DR5, DR7
62
Gram positive rods
Bacillus Clostridium Listeria
63
Gram positive cocci
Strep Staph
64
Gram negative rods
Klebsiella Enterobacter Salmonella Shigella Legionella Campylobacter Pseudomonas
65
Gram negative cocci
Neisseria
66
Q fever bug
C burnetti
67
Most common transmission Hep C
Contaminated blood transfusion IVDU (also sex, vertical) NO VACCINE
68
Chronic complications Hep C
Cirrhosis Hepatocellular carcinoma
69
Dengue features
fever headache retro orbital pain back ache rash mucosal haemorrhage, shcok
70
HIV genetics
single stranded RNA
71
Immune changes in HIV
decreased CD4, CD8 hypergammaglobulinaemia decreased macrophage
72
Virus causing T Cell leukaemia
HTLV 1
73
Virus causing Kaposis sarcoma
HHV 8
74
HBsAg
Surface antigen = current disease (or carrier)
75
Anti Hbs
Immune
76
Anti Hbc
Current or previous infection
77
HIV test method
ELISA Western blot
78
Causes of false positive treponomal tests
Genital herpes Psoriasis RA SLE
79
Egg vaccines
Flu, yellow fever
80
Live vaccines
MMR Polio Chicken pox Yellow Fever Typhoid
81
Von Willebrands Rx
DDAPV, TXA
82
Gauchers disease
Jewish hepatosplenomegaly, anaemia, osteopaenia
83
Type I cryoglobulin
Waldenstroms
84
Type II cryoglobulin
Hep C, HIV
85
Type Iii cryoglobulin
Sjorgens
86
OD causing respiratory alkalosis
Aspirin, Theophyllines
87
C1 Inhibitor deficiency
Hereditary angioedema
88
C2, C4 deficiency (classic pathway)
HSP Glomerulonephritis SLE Strep Staph
89
C3-C9 deficiency
Recurrent bacterial infection e.g Neisseria
90
Ataxic Telangoectasia syndrome (inheritance, features, Ig)
autosomal recessive kids - cerebellar ataxia, oculocutaneous telangiectasia, recurrent sinus/lung infections Low IgA, IgE Possible T cell deficiency
91
Wiskott Aldrich syndrome
X linked recessive Eczema, thrombocytopaenia, recurrent infection Lymph tumours Low antibody, IgM high IgE B and T cell WASP
92
Raised IgG in liver disease
hepatitis, cryptogenic cirrhosis
93
Raised IgM in liver disease
biliary/alcoholic cirrhosis
94
Raised IgA in liver disease
alcoholic cirrhosis
95
Anti smooth muscle +ve
Hepatits PBS Cirrhosis Viral infection
96
Anti mitochondrial +ve
PBC Hepatitis Cirroshsi
97
Gastric parietal cell antibody +ve
Pernicious anaemia Atrophic gastrisi Autoimmune thyroid disease
98
Thyroid autoantibodies
Hashimotos Graves Hypothyroidism Pernicious Anaemia
99
ANA +ve
Sjorgens Lupus RA MG Hashimotos UC
100
cANCA
Wegeners granulomatosis Microscopic polangitis
101
pANCA
Idiopathic crescentic glomerulonephritis Microscopic polyangitis Churg Strauss
102
Hyperacute organ rejection presentation
Hours Complemented mediated Vascular spasm, occlusion, failed organ perfusion
103
Acute organ rejection
Days to weeks HLA incompatibility T cell/CD4
104
Chronic organ rejection
months-years T Cells
105
What cells mediate graft versus host disease
T cells
106
Causes of +ve Coombs test
haemolytic anaemia/tranfusion reactions LSE, lymphoma, leukaemia Methyldopa
107
Loss of forearm pronation Weak wrist flexion Thenar wasting
Median nerve palsy
108
Wasting hand muscles, hypothenar Claw hand Radial deviation
Ulnar nerve
109
Paralysis of knee flexion Foot drop Ankle jerk and plantar reflex absent
Sciatic nerve palsy
110
What controls motor function
Basal ganglia
111
Anterior Cerebral Artery Occlusion
weak, numb contralateral leg mild arm signs face spare
112
Middle Cerebral Artery Occlusion
Contralateral hemiplegia sensory loss face dyphasia/dyspraxia contralateral homonynmous hemianopia
113
Vertebrobasilar artery occlusion
Hemianopia Cortical Blindness Vertigo, nystagmus hemi/quadraplegia sensory loss, drop attacks, cerebellar sx
114
Lateral Medullary infarct = Posterior Inferior Cereberal Artery Infarct
vertigo, vomiting, nystagmus TOWARDS lesion ipsilateral hypotonia ataxia horners soft palate paralysis
115
Brocas dysphasia
Inferolateral frontal lobe non fluent speech comprehension intact
116
Wernickes dysphasia
posterior superior temporal lobe Fluent speech but errors Issues reading, writing, comprehension
117
Fanconi syndrome
cystinuria, phosphaturia, RTA 2, glycosuria, rickets/osteomalacia
118
What do Th1 Helper cells secrete?
Cell mediated immunity IFN gamma IL2, IL3
118
What do Th2 helper cells secrete?
Humoural immunity IgE IL4, IL4, IL6, IL10, IL13
119
Nacrolepsy HLA
HLA DR2
120
Nicotinic Acetylcholine what type of Receptor
Ligand gated
121
Whats the usual outcome measure of a cohort study?
Relative risk
122
Fabry disease
Angiokeratomas “corneal whirl” Proteinurias Early MI/stroke
123
Shistocytes in blood smears
DIC
124
What type of receptor is ANP
Guanylate cyclase
125
Chi squared test
Comparing 2 percentages/proprotions
126
Mechanism of doxy
Inhibits 30s unit ribosomes
127
Achondroplasia mutation
FGFR3 fibroplast growth receptor
128
Achondroplasia inheritance
autosomal dominant
129
Features of achondroplasia
short arms and legs, short, flat nose
130
Bartters syndrome
Severe hypokalaemia defective chloride absorption Na+/K/Cl cotransporter loop of henle
131
Tay Sachs disease
lysosomal storage cherry red spot macula no hepatospelnomegaly developmental delay
132
Mcardles disease
glycogen storage myalgia myoglobinuria
133
Homocystinuria features
fine, fair hair Marfanoid LD downwards (inferonasal) dislocation of lens VTE also malar flush, livedo reticularis
134
Pathophysiology of homocystinuria
cystathionine beta synthase
135
Tetralogy of Fallot
VSD RVH right ventricular outflow tract obstruction, pulmonary stenosis overriding aorta
136
Goodpasture HLA
HLA DRB1\*15:01
137
Ank spond renal disease
AA amyloidosis - apple green +ve bifringence, enlarged kidneys, heavy proteinuria IgA nephropathy
138
UC Vs Crohns Transmural inflammation
Crohns
139
UC Vs Crohns Fissuring ulcers
Crohns
140
UC Vs Crohns Lymphoid/neutrophil aggregates
Crohns
141
UC Vs Crohns Mucosa/submucosa only
UC
142
UC Vs Crohns Crypt Abcesses
UC
143
UC Vs Crohns Skip lesions
Crohns
144
UC Vs Crohns Continous inflammation
UC
145
UC Vs Crohns Transmural/all layers inflammation
Crohns
146
Few polyps and fhx of cancer
HNPCC
147
Loads of polyps (100s-1000s) and fhx of cancer
FAP
148
HIV nephropathy histology
Microcystictubular dilatation Collapsing FSGS
149
CMV Tx
Gancliclovir
150
Which antibodies cross the placenta
IgG
151
Initial therapy for phaeochromocytoma SVT
Phenoxybenzamine
152
Philadelphia chromosome in ALL good/bad prognosis?
Bad
153
Weber syndrome
Midbrain stroke THIRD NERVE PALSY SAME SIDE Contralateral hemiparesis and hemiparkinsonism
154
Wallenberg syndrome
Lateral medullary syndrome Ipsilateral pharyngeal/ palatal palsy Ipsi horner syndrome Ipsi pain/temp loss face Contra pain/temp loss body
155
MOA/enzyme glitazone
CYP2C8
156
SVT in pregnancy tx
Beta blocker
157
Hyperlipoproteinaemia IB mutation
Apolipoprotein CII (APO CII)
158
Red spots with bluish white centre
Koplik spots Measles
159
Sheep, lymphadenopathy Fever Sweats Weight loss
Brucellosis
160
Tx for cholera
Doxy
161
Which immunoglobulins are responsible for haemolytic blood transfusion reactions?
IgM
162
Homocystinuria pathophysiology
deficiency of cystathionine beta synthase
163
Homocystinuria features
fine, fair hair Marfanoid LD downwards (inferonasal) dislocation of lens VTE also malar flush, livedo reticularis
164
Homocystinuria tx
B6 supplementation
165
Conditions ax with turners
Cystic hygroma Lymphedema Hypothyroidism Horseshoe kidney Crohns
166
Features CF
short stature diabetes mellitus delayed puberty rectal prolapse nasal polyps male infertility, female subfertility
167
Main constituent of pulmonary surfactant
dipalmitoyl phosphatidylcholine (DPPC)
168
Lesch-Nyhan syndrome
X recessive juvenile gout absence HGPRT orange sand stools
169
Liddles syndrome
Hypokalaemia HTN
170
Wilcoxon signed-rank test -
compares two sets of observations on a single sample eg before/after
171
DiGeorge Mnemonic
'CATCH22 C - Cardiac abnormalities A - Abnormal facies T - Thymic aplasia C - Cleft palate H - Hypocalcaemia/ hypoparathyroidism 22 - Caused by chromosome 22 deletion
172
Kearns-Sayre syndrome
mitochondrial inheritance onset \< 20-years-old external ophthalmoplegia retinitis pigmentosa
173
Beckwith-Wiedemann syndrome
organomegaly, macroglossia, abdominal wall defects, Wilm's tumour neonatal hypoglycaemia.
174
Complement Leiner disease
C5
175
Norepinephrine receptor
G protein coupled receptor
176
Dermatitis herpetiformis HLA
HLA D3
177
Ligand gated ion receptors
Nicotinic acetylcholine Gaba glutamate
178
Tyrosine kinase receptors
insulin-like growth factor (IGF), epidermal growth factor (EGF) PIGG(L)ET: Prolactin, Immunomodulators GH, G-CSF, Erythropoietin Thromobopoietin
179
Guanylate cyclase receptors
ANP/BNP
180
HLA Psoriasis
HLA CW6
181
T1 RTA Anion gap
Normal
182
Lactic Acidosis Anion Gap
Raised
183
T1 RTA presentation
hyperchloraemic hypokalaemic metabollic acidosis
184
Linear IgG desposits
anti glomerular basement membrane disease
185
MOA sitagliptin
DPP-IV inhibitor
186
Tx cluster headaches
verapamil
187
Lip smacking seizure - which area of brain
Temporal lobe
188
CXR "mass surrounded by rim of air"
Aspergilloma
189
MODY presentation
diabetes without ketones antibody negative autosomal dominant family hx
190
Latent Autoimmune Diabetes Adult LADA Presentation
Treated as Type 2 for few years High BMS Ketonuria Hx of auto immune
191
Warm AIHA features
Happens at body temp Anaemia + jaundice +splenomegaly Coombs test +ve
192
Cold AIHA features
Worse cold temp Raynauds/purplish discoloration (acronyansosis) Coombs test +ve
193
White turbid fluid joint
Acute Gouty Arthritis
194
1st step tx aortic dissection
Labetalol
195
Haemochromatosis inheritance
Autosomal recessive
196
Haemochromatosis pathophysiology
mutation of HFE on chromosome 6 C282Y (80%) AND H63D (20%) cause decreased hepcidin
197
Heinz bodies
GP6D deficiency
198
Howell Jolly bodie
Hyposplenism/splenctomy
199
Rouleax (blood film)
Waldenstroms, myeloma
200
Warm AIHA features
Happens at body temp Anaemia + jaundice +splenomegaly
201
Cold AIHA features
Worse cold temp Raynauds/purplish discoloration (acronyansosis)
202
Warm AIHA Ig
IgG
203
Cold AIHA Ig
IgM
204
What infections does Sickle Cell predispose to ?
encapsulated eg strep pneumoniae, salmonella
205
What organism causes aplastic sickle cell crisis?
Parvovirus (Causes sudden drop in Hb)
206
"Pulmonary infiltrates" in sickle cell
Acute chest syndrome
207
Acute chest syndrome sickle cell presentation
SOB, chest pain, pulmonary infiltrates, hypoxia
208
Long term tx sickle cell
hydroxyurea
209
Carcinoid tumour features
tachycardia flushing bronchoconstriction haemodynamic instability diarrhoea
210
"lambda light chain" in kidney
myeloma amyloidosis
211
Tramline spine
Ank spond bamboo spine
212
Rugger Jersey spine
Renal osteodystrophy
213
Trophozites/cysts in stool culture
Giardia
214
Type II RTA
Hypokalaemic hyperchloraemic acidosis with low bicarb (high in urine) and high urine pH
215
Cisplatin side effects
Ototoxicity nephrotoxicity - hypokal, mag, calc
216
Tx for Hep C
Daclatasvir, sofosbuvir +\_ ribavirin
217
Ciclosporin mechanism
IL2 inhibitor
218
Small testes, delayed puberty, loss of smell
Klamanns syndrome
219
Retinal protein responsible for light perception
rhodopsin
220
Boney lumps DIP
Heberdens nodes OA
221
Boney lumps PIP
Bouchards node RA
222
Von Hippel Lindau
Cysts tumours everywhere Chromosome 3 RCC common
223
Scheuermanns disease
irregular endplates loss of disc space height teenage girls thoracic smooth lump
224
Hormone change at ovulation
LH surge
225
Net like rash
Cholesterol emboli
226
Sickle cell treatment
Hydroxyurea
227
McArdle disease
Repeated cramping and myoglubinuria (dark drown urine) after exercise
228
Illness where prophylaxis causing haemolytic anaemia
G6PD deficiency
229
Hypersegmented neutrophils
Megaloblastic anaemia
230
Left shift of myeloid cells
Pregnancy, severe infection, CML
231
Blast cells
AML/ALL
232
Auer rods
AML
233
Smear/smudge cells
lymphocytosis usually CLL
234
Primary thrombocytopaenia features
Bleeds/clots splenic infarcts/atrophy raised megakaryoctyes
235
Primary thrombocytopaenia tx
hydroxycarbamide, alpha interferon, anagrelide aspirin
236
Polycythaemia rubra vera features
Clots - headaches, dizziness, VTE, stroke, hepatosplenomegaly
237
Tear drop poikilocytes
Myelobfibrosis
238
What condition often turns into myelofibrosis?
PRV
239
What condition does myleofibrosis often turn into?
AML
240
Most common leukaemia adults
AML
241
Philadelphia chromosome in ALL ?prognosis
Poor prognosis
242
CLL presentation
painless lymphadenopathy + anaemia Smear cells
243
Reed Sternberg cells "owls eye" appearance
Hodgkins lymphoma
244
Most common type of Hodgkins
Nodular sclerosing women good prognosis
245
High number Reed Sternbergs ?Hodgkins type
Mixed cellularity
246
Best prognosis Hodgkins
Lymphocyte predominant
247
Worst prognosis Hodgkins
Lymphocyte depleted
248
Poor prognostic factors in AML
\>60 \>20% blasts after 1st chemo deletion chromosome 5 or 7
249
Acute promyelocytic leukaemia genetics and cells
t15:17 fusion of PML and RAR alpha Auer rods
250
"Increased granulocytes at different stages of maturation +- thrombocytosis"
CML
251
CML genetics
t9:22 q34:11 BCR-ACL
252
CML treatment
imatinib - tyrosine kinase inhibitors
253
Leukaemia presenting with DIC
APML
254
Good prognostic factors ALL
FAB L1 type common ALL Pre-B phenotype low initial WCC del 9p
255
Poor prognostic factors ALL
FAB L3 type T or B cell markers Philadelphia \<2 or 10\< male CNS involvement high WCC not white Hypodiploidy
256
"monoclonal proliferation well differentiated B lymphocytes"
CLL
257
Ann Arbor Stage I
single region lymph nodes
258
Ann Arbor Stage II
2 sites same side of diaphragm
259
Ann Arbor Stage III
several sites both sides of diaphragm
260
Ann Arbor Stage IV
extralymphatic structures
261
Tumour lysis syndrome
High phos, potassium, uric acid Low Ca2+
262
Mantle cell lymphoma genetics
CD5+, CD19+, CD22+, CD23-, CD10- t11:!4
263
Follicular lymphoma genetics
t 14:18 BCL 2
264
TTP antibody
ADAMTS 13
265
What clotting factor does Von Willebrand process
Factor VIII carrier protein
266
What factors doe Haemophilla A affect
Factor VIII
267
What factors doe Haemophilla B affect
IX
268
DIC blood features
prolonged PT, APTT, thrombin clotting WCC, platelet, fibrinogen low
269
Chemo agent causing low Mg
cisplatin
270
Causes of intravascular haemolysis
Blood transfusion G6PD TTP DIC HUS PNH Cold AIHA
271
Causes of extravascular haemolysis
Sickle cell, thalasaemia Hereditary sphereocytosis Haemolytic of newborn Warm AIHA
272
Haemophilia PT/APTT
PT normal APPT prolonged
273
Antiphospholipid pregnancy tx
Aspirin and LMWH
274
Prognostic marker for myeloma
B2 microglobulin
275
MOA cisplatin
cross linking DNA
276
Haem issue causing headache, blurred vision
Waldenstroms
277
Causes warm AIHA
SLE methyldopa
278
Causes cold AIHA
Mycoplasma, EBV
279
Surgical prophylaxis Von Willebrands
Desmo
280
Leukaemiod reaction (rather than leukaemia)
high leucocyte alkaline phosphatase score Dohle bodies white cells Left shit neutrophils
281
Von Williebrand PT/APTT
Mildly prolonged APTT
282
CLL poor prognostic markers
male \>70 lymphocyte \>50 lymphocyte doubling \<12 months raised LDH CD38 TP53 del 17
283
CLL good prognosis
del 13
284
Hereditary spherocytosis features
Fhx, gallstones, anaemia splenomegaly FTT EMA binding test
285
Glutide main side effects
Hypos plus pancreatitis, renal imp, nausea and vomiting
286
Ca 125
Ovarian Peritoneal
287
ECOG 0
Normal
288
ECOG 1
Can't do strenuous stuff, but ok with work
289
ECOG 2
Ambulatory and ADLs but not capable of work
290
ECOG 3
Limited self care, confined to be more than 50% waking
291
Dapaglifozin SGLT2 risks
DKA Increased cholesterol
292
Med to reduce risk of tumour lysis
rasbicurase
293
JAK 2
Thrombocythaemia
294
Sickle cell HbSC
Mild disease
295
Hereditary spherocytosis tx
Fluids, high dose folic acid
296
Diabetes meds contraindicated in CCF
Pioglitazone
297
G6PD triggers meds
primaquine cipro sulphs
298
Test for anaphylaxis post reaction
tryptase
299
Hodgkins poor prognostic markers
weight loss \>10% 6 months fever \>38 night sweats
300
Acute intermittent porphyria enzyme defect
Uroporphyrinogen decarboxylase
301
Factor V Leiden mechanism
resistance to activated protein C
302
Common cancer tumour lysis syndrome
Burkitts lymphoma
303
Necrosis following warfarin
Protein C deficiency
304
What does polycythaemia vubra vera progress to?
Myelofibrosis, AML
305
Bilobed mononuclear cells
AML
306
Liver transplant criteria paracetamol OD
pH \<7.3 or INR \>6.5 + grade 3/4 encephalopathy + Cr \>300
307
Hypovolaemia shock post MI
RV infarct
308
Most common thyroid cancer
Papillary, great prognosis
309
Type and MOA pioglitazone, rosiglitazone
PPAR gamma agonist, increase insulin signalling/sensitivity
310
Conns triad
HTN + hypokalaemia + alkalosis
311
Conns causes
RAS CAH CCF Corrhosis Nephritic syndrome
312
Waterhouse Fredichsen
Septicaemia causing adrenal haemorrhage causing addisons
313
Primary hyperparathyroid
Tumour producing PTH High PTH HIgh Ca2
314
Secondary hyperparathyroid
Vit d deficiency Low/normal ca High PTH
315
Tertiary hyperparathyroidism
Secondary hyperparathyroidism goes on for ages causing high PTH, causing high Ca2
316
Hyperaemic membranes
TSS
317
Where do SGLT 2 inhibitors glifozins work
Early PCT
318
Glutide main side effects
Hypos
319
Indications for surgery in HPTH
\<50 CA \>0.25 upper lmit eGFR \<60 renal stones/nephrocalcinosis osteoporosis sx
320
Mst common cause primary hyperaldoteronism
Adreanl hyperplasia
321
Pendred syndrome
Deafness and hypothyroid
322
MOA gliptins
DPP 4 inhibitors
323
Dapaglifozin SGLT2 MOA
Stops reabsorption glucose proximal renal tubule
324
Dapaglifozin SGLT2 risks
DKA
325
Normal fasting glucose
\<6.1
326
Post glucose /random glucose
\<7.8
327
Kallmans syndrome
Like kleinfelters but low LH, FSH and crypto orchidism
328
Sulfonylureas MOA
increase insulin secretion B cells and decrease hepatic clearance
329
MODY 3
most common ax with HNF alpha inc risk HCC
330
MODY 2 gene
glucokinase
331
MODY 5
rare cysts HNF 1 beta
332
Gitelmans syndrome
Defect in Na Cl transporter DCT Normotension Hypokalaemia Hypocalciruia Hypomagnesaemia Met alk
333
Target HbA1c T1DM
48
334
Estrogen only HRT risk
Endometrial ca
335
Supressed by high but low dose dex suppresion test
Cushings disease
336
Diabetic meds that dont cause hypos
Metformin Glitazones Gliptins
337
Diabetic meds that do cause hypos
Gliclazides Exanatides
338
Type and MOA gliclazide, glimperide
Sulfonylureas, inhibit K ATPase
339
Type and MOA exanatide, lirglutide
GLP 1 stimulates GLP1 receptor, Ca2+ influx, inc insulin
340
Type and MOA sitagliptin, linagliptin
DDP4 inhibitors Stops breakdown of GLP1
341
Type and MOA pioglitazone, rosiglitazone
PPAR, increase insulin signalling/sensitivity
342
Type and MOA empagliflozin, dapagliflozin
SGLT 2 inhibitors inhibit kidney reabsorption of glucose, excretes more in urine
343
Type and MOA acarbose
alpha glucosidase inhibitor inhibits gut absorption of glucose
344
What are insulin stress tests used for
Cushings vs pseudo cushings
345
Addisons electrolyes/ph
Low Na High K Acidotic
346
Hookworm presentation
itchy rash then resp asthma/allergy sx, the GI upset +- anaemia India
347
Pseudohypoparathyroidism bloods
PTH: high calcium: low phosphate: high
348
Pseudohypoparathyroidism features
short fourth and fifth metacarpals short stature cognitive impairment obesity round face
349
Pseudohypoparathyroidism genetics
G protein mutation auto dom
350
Well done!
.
351
Impaired glucose tolerance
7.8-11.1
352
How to test for Zollinger Ellison
Serum gastrin Ocreotide scan
353
Impaired fasting glucose
6.1-7
354
Impaired glucose tolerance
7.8-11.1
355
Tx Listeria meningitis
aciclovir, cef, ampicillin
356
Painless solitary genital ulcer
Syphillis
357
Painless genital ulcer painful lymphadenopathy
Lymphogranuloma verenum
358
Painful ulcer Painful lymphadenopathy
Chancroid (Haemophilis ducrei)
359
What does ezetimibe do
redcues intestinal cholesterol absoprtion
360
CSF TB Meningitis
very low glucose
361
Enterovirus meningitis
cold, diarrhoea preceding resp/faeco-oral spread creche
362
Necrotising pneumonia predeing viral illness empyema/abcess
Staph aureus
363
Adult Stills Disease
Fluctuating salmon Pink rash Arhtralgia Hepatosplenomegaly Fever
364
Azothiaprine eznyme
TPMT thiopurine methyltranferase
365
Intracranial bleed with cranial nerves, hyponatraemia, hypokalaemia
Pituitary apoplexy
366
Cholestrymine on INR
Lower
367
Abx worsening SE of statin
clarithromycin
368
SHBG in PCOS
Low
369
Intoxicated, high BP, high HR, low K+
amphetamines
370
Muscle weakness in medial epicondylitis/ulnar nerve palsy
adductor pollicis
371
Hookworm presentation
Rash then resp asthma/allergy sx, the GI upset +- anaemia India
372
definitive test myotonic dystrophy
Genetic testing
373
APML tx
all trans retinotic acid ATRA
374
Reasons to stop stress test
\>250/115 2mm ST depression lateral leads
375
What age to continue HRT to in early menopause
51
376
Exogenous insulin on C peptide
supresses
377
How to test for Zollinger Ellison
Serum gastrin
378
Tx for chlamydia pneumonia
Erythromycin
379
physiological pred dose for 75kg man
7.5mg
380
1st line tx OCD
CBT, ERP
381
Thrombolysis window stroke
4.5 hours
382
Vitamin supplement in CF
Vitamin A
383
Hormone pattern PCOS
High LH, normal FSH, normal estradiol, high testosterone
384
Right sided stroke, DVT ?cause
PFO
385
Choroid neovascularisation Dye stain leaking at macula ?diagnosis
Age related macular degeneration Tx anti VEGF
386
SE/caution of tevinor/truvada (HIV med)
renal impairment
387
Painless transient visual loss Curtain descending ?diagnosis
amaurosis fugax
388
Amaurosis fugax tx
Clopidogrel
389
Ulcers ax with RA
Pyoderma gangrenosum
390
Photosensitive blistering rash Ax with alcohol, HIV, hep, estrogen
Porphyrea cutanea tarda
391
Intestinal Bacterial Overgrowth
E coli/bacteroides Presents diarrhoea, B12 deficiency tx with metro
392
Prolactinoma medical management
Cabergoline (dopamine agonist)
393
Which anti malarials are contra indicated in epilepsy
mefloquine chloroquine
394
Malaria prophylaxis in pregnancy
chloroquine folate supplements
395
Causes of raised transfer factor
Asthma Pulmonary haemorrhage Weg/goodp L to R shunt polycythaemia hyperkinetic male exercise age
396
Causes of low TLCO
Pulmonary fiborsis pneumonoa PE pulmonary edema emphysema anaemia Low cardiac output
397
Primary Sclerosing cholangitis features
Cholestatis pANCA male jaundice, pruritis, fatigue
398
PMR symptoms
raised ESR, CRP Weight loss/anorexia Normal CK
399
Anastrazole mechanism
blocks peripheral tissue conversion of androgen to estrogen
400
Pneumonectomy eligibility criteria
FEV \>2L FEV \>50% of FVC Normal PaC02 at rest
401
When do you use CEA for colorectal ca
post op surveilance
402
Rhomboid shaped crystals on joint aspiration
pseudogout - pyrophosphate arthritis/chondrocalcinosis
403
Rash "concentric rings varying colours"
Erythema multiforme
404
Hep E endemic region
North Africa
405
Trauma -\> muscle wasting of whole hand
T1 nerve root damage
406
Other antibodies ax with anti phospholipid
anti b2 glycoprotein anti cardiolipin
407
Dig toxicity
Complete heart block Nausea/vom Yellow vision Brady/hypo
408
Complete heart block post MI ?which vessel
Posterior interventricular artery
409
1st line for acne and hirstutism in PCOS
Dianette Co-cyprindol
410
What causes in renal impairment in rhadomyolysis
Myoglobin
411
Botulin vs tetanus
Tetanus is rigid paralysis, botulin is flaccid
412
VTE and nephrotic syndrome
Anti thrombin III deficiency
413
PPAR drugs
fenofibrate
414
Immunoglobulin well person, allergic reaction blood
IgA
415
Familial primary pulmonary HTN sx
SOB, faitgue, angina raised JVP Left parasternal heave pansystolic mrumur S4 peripheral edema
416
Acanthosis nigricans ax illness
gastric adenocarcinoma, endometrial carcinoma
417
Cyanotic but not hypoxic
methaemoglobinaemia sulfonamide exposure tx methylene blue
418
Pneumonia: Young person out of keeping radiology muscle ache cold agglutins
Mycoplasma
419
Pontine haemorrhage stroke ?Vessel
Basilar artery
420
Malignant otitis externa
Otitis externa spreading to temporal bone/skull Facial nerve involvement Caused by pseudomonas aeruginosa
421
Trigeminal neuralgia sx with sensory loss
Tumour
422
Tx for recurrent renal stones with hypercalciruia
Thiazide diruetic
423
Indications for pacemaker
persistent symptomatic bradycardia Trifasicular block mobitz type 2 AV block sinus pause \>3s
424
Anterior MI v1-v6
LAD
425
Septal M1 V1-V4
LAD septal branches
426
Lateral MI I, aVL, V5, V6
Left circumflex
427
Inferior MI II, III aVF
Right coronary artery (80%) or Right circumflex (20%)
428
Posterior MI V7, V8, V9
RCA
429
Right ventricle MI VI, V4R
RCA
430
Thoracic Outlet Syndrome
Pulse disappears when arm raised above head pain, parathesia, numb arm Ix doppler
431
Lipaemic sample pancreatitis
Triglycerides/chylomicrons
432
Power of study definition
probability of rejecting null hypothesis when its false
433
Cancer PSC progresses to
cholangiocarcinoma
434
Digital ischaemia tx
phentolamine
435
Gabapentin mechanism
binds to alpha 2 delta on voltage gated calcium
436
Skin plaques and acid fast bacilli
Leprosy
437
Pramaquine MOA
Removes hypnozites from liver
438
Somatostatin effect
Reduces gastrin secretion Reduces gastric motility
439
Modified glasgow pancreatitis criteria
Age O2 WCC Ca ALT LDH Glucose Urea Albumin
440
2nd line for animal bite
doxy and metro
441
T2DM med to avoid in gastroparesis
GLPT 1 glutides
442
Visual change with benign ICH
Enlarged blind spot Constriction visual field
443
Yellow fever
Flavivirus flu, epigastric pain, bruising, bleeding gums, fever
444
Doxasoin SE
worsens CCF peripheral edema palpitations
445
Pseudohypoparathryoidism mechanism
loss of function G protein linked to PTH receptor
446
Sx constrictive pericarditis
Raised JVP steep Y descent pusatile liver Right heart failure
447
Kidney disease ax with syphilis
Rapidly porgressive glomerulonephritis
448
Worst alpha 1 anti trypsin phenotype
PIZZ
449
Best alpha 1 anti trypsin phenotype
PISS
450
CYsticerosis
tapeworm lump + seizure
451
Headache better lying flat
Intracranial hypotension
452
Tx PHT with multi focal atrial tachcardia
verapamil
453
MOA propylthiouracil
inhibits conversion thyroxine to tri iodothyonine
454
Acute pain Small irregular oval pupil photophobia red eye, lacrimation CILLARY FLUSH, hypopyon
Anterior uveitis
455
Anterior uveitis tx
atropine, cyclopentolate steroid eye drops
456
Hutchinsons sign HZO
Rash on tip or side of nose nasocillary involvement, strong risk factor ocular involvement
457
HZO tx
PO anti virals 7-10 days can use topical steroids for any inflammation
458
Severe pain Decreased visual acuity semi dilated pupil Hazy cornea, halos
Acute angle closure glaucoma
459
Acute onset pain blurred vision photophobia small, fixed, oval pupil, ciliary flush
Anterior uveitis
460
Visual loss following surgery Red eye pain
Endopthalmitis
461
Pathophysiology thyroid eye disease
glycosaminoglycan and collagen deposition in the muscles
462
Management thyroid eye disease
Lubricants Steroids radiotherapy surgery
463
Red flags thyroid eye disease
deterioration in vision change in color eye pops out corneal opacity cornea visible when eyes closed disc swelling
464
Bilateral gritty/discomfort sticky eyes in morning red eyelid margins +- swollen eyelids, styles, chalazions
Blepharitis
465
Blepharitis tx
Hot compress Lid hygiene artificial tears
466
Reduced vision faded colour glare halos defect in red reflex
Cataracts
467
Cataracts risk factors
smoking, DM, alcohol, trauma long term steroids radiation myotonic dystrophy hypocalcaemia
468
Complications of cataract surgery
posterior capsule opacification retinal detachment endophthalmitis
469
Keratitis organisms
bacterial - staph a, pseudomonas aeruginosa contact lens funga amoebic keratitis (soil/contaminated water) parasitic onchocercal river blindness HSV exposure
470
Red eye photophobia foreign body/gritty hypopyon
Keratitis
471
Management keratitis
topical abx cycloplegic for pain
472
Complications of keratitis
corneal scarring perforation endopthlamitis visual loss
473
Redness/swelling severe ocular pain visual disturbance proptosis pain/opthalmoplegia on eye movements eyelid edema/ptosis
Orbital cellulitis
474
Orbital cellulitis vs preseptal cellulitis
reduced visual acuity, proptosis, pain/opthalmoplegia on eye movements = orbital cellulitis
475
Floaters Flashers blurred vision Cobwebs across vision dark curtin descending Weiss ring
Posterior vitreous detachment
476
Posterior vitreous detachment tx
should self resolve if retina tear will need treatment
477
Risk factors for vitreous detachment
Age Myopia
478
Cupping of disc
glaucoma
479
Tx glaucoma
prostaglandin analogue eye drops 2nd line beta blocker, carbonic anhydrase / sympathomimetic
480
Prostaglandin analogue eye drops
increases uveoscleral outflow brown pigmentation eye, increases eye lash length
481
Beta block eye drops
avoid in asthmatics or heart block
482
Sympathomimetics e.g brimonidine
Reduces aqueous production and increased outflow Avoid if taking MAOI or TCA, causes hyperaemia
483
Carbonic anhydrase inhibitor eyedrops eg Dorzolamide
Reduces aqueous production, sulphonamide like reactions
484
Miotic eye drops e.g pilocarpine
increase outflow SE constricted pupil, headache, blurred vision
485
Dry macular degeneration
90% of all Drusen spots - yellow spots in bruchs membrane
486
Wet macular degeneration
choroidal neovascularisation eudative worst prognosis
487
ARMD sx
decreased visual acuity (near) poor dark vision fluctuating visual disturbance photopsia/glare distortion of ines Amsler grid red patches/drusen spots
488
Supplements for dry ARMD
Vit A, C, E and zinc no beta carotene for smokers
489
Angioid retinal streaks
dark red streaks on fundoscopy caused by breaks in bruchs membrane ax pseudoxanthoma elasticum, ehler danlos, pagets, sickle cell, acromegaly
490
"plucked chicken" skin
psuedoxanthoma elasticum
491
Treatment of acute glaucoma
acetazolamide + pilocarpine
492
What is a Holmes Adie pupil
Dilated and slow to react pupil little/no response to light absent/poor tendon reflexes
493
"Pale well demarcated disc" on fundoscopy
Optic atrophy
494
Acquired causes optic atrophy
MS Papilloedema raised IOP Retinal damage ischaemia toxins nutrition B1, B2, B6 , B12
495
Cogenital causes optic atrophy
Friedreich ataxia Mitochondrial disorders DIDMOAD (DI, DM optic neuropathy, deafness)
496
Most common RA eye disease
keratoconjunctivitis sicca
497
RA red eye painless no itch
episcleritis
498
RA dry, itchy
sicca
499
RA red painful eye
scleritis
500
Causes of tunnel vision
papilloedema glaucoma retinitis pigmentosa choroidoretinitis optic atrophy hysteria
501
Argyll Robertson pupil
accommodate but dont react tertiary syphilis
502
HZO tx
PO aciclovir
503
Ramsay hunt
HVV FACIAL nerve (HZO is TRIGEMINAL)
504
Sudden loss of vision + severe retinal haemorrhages on fundoscopy
Central Retinal Vein Occlusion
505
Cherry red spot on pale retina
Central retinal artery occlusion
506
Night blindness + tunnel vision
Retinitis pigmentosa
507
Confusion and papilloedema
Vit A toxicity
508
Causes of RAPD
Retina detachment Optic neuritis MS
509
RAPD (Marcus gunn)
light shone into affected eye both eyes dilate
510
Kidney disease ax retinitis pigmentosa
Alports syndrome
511
Visual loss - dense shadow starting peripherally moving inwards
Retinal detachment
512
Enlarging dark spots in vision
Vitreous haemorrhage
513
Stage I hypertensive retinopathy
Arteriolar narrowing, tortusoity Increased light reflex, silver wiring
514
Stage II hypertensive retinopathy
AV nipping
515
Stage III hypertensive retinopathy
Cotton wool eudates Flame blots haemorrhages
516
Stage IV hypertensive retinopathy
Papilloedema
517
Mild NPDR
1 or more microaneurysm
518
Moderate NPDR
Microaneurysms blot haemorrhage hard excudates cotton wool spots venous beading/lopping
519
Severe NPDR
blot haemorrhages and microaneurysms 4 quadrants venous beading 2 quadrants IRMA 1 quad
520
Diabetic Proliferative retinopathy
neovascularisation fibrous tissue ant to disc
521
Diabetic Maculopathy
hard exudates
522
Friedrichs ataxia
cerebellar sx L and UMN pes cavus normal IQ optic atrophy pale disc
523
intracranial bleed causing fluctuating confusion over time
subdural
524
Tx neuroleptic malignant sydrome
dantrolene
525
Cancers ax with von hippel lindau
clear cell renal hemangiomas
526
PD vs drug induced parkinsons
PD = rigid, resting tremor DIP = bilateral sx
527
Huntingtons genetics
trinucloetide repeat CAG auto dom
528
MS tx
beta inteferon
529
GBS paralysis
flaccid hyporefflexia, tachycardia
530
Miller Fisher syndrome
areflexia, ataxia opthalmoplegia variant of GBS
531
NF1
Cafe au lait Axillary/groin freckles Peripheral neurofibromas Lisch nodules scolisos phaeochromcytoma
532
NF2
Bilateral vestibular schwannomas meningomas ependynomas intracranial schawnommas
533
Tuberous sclerosis
Ash leaf spots adenoma sebaceum shagreen patches subungal fibroms epilepsy develpmental delay retinal haematomas
534
Migraine acute tx
triptan
535
Migraine prophylaxis
tompiramate, propanolol
536
Tx for drug induced PD
benzhexol
537
"slow relaxing grip"
myotonic dystrophy
538
Loss of corneal reflex
acoustic neuroma
539
Dementia and myoclonus
CJD
540
Autonomic dysfunction +PD/cerebellar signs
multi systems atrophy
541
Long term prophylaxis cluster headaches
Verapamil
542
Patchy haemoorahgic change on MRI Head
HSV encephalitis
543
Thrombectomy window
6 hours
544
Intracranial bleed - hypodense not confied to suture lines
chronic subdural
545
Epsilon sign
Right ventricular dysplasia
546
Test for acute Hep C
HCV RNA
547
Kussmaul sign
insp inc venous pressure, steep y jvp - perocarditis
548
tx broad beta
fibrate
549
NMS vs serotonin
serotonin = myoclonus, hyperreflexic, tremor NMS = rigid
550
loose bodies in joint
osteochondritis dissecans
551
onion peel bone
ewings sarcoma
552
Thailand Subcut nodule pus gram neg bacellie
meliodosis
553
Main clinicl sign of left ventircular dysfunction
4th heart sound
554
amitriptyline OD with VT tx
bicarb
555
Bone mets with breast ca pain relief
Bisphosphonates
556
Raised ALP, cortical thickening, trabceular pattern
Pagets
557
PD tx
interfering - levodopa not intefering - dopamine receptor agonist eg ropinrole
558
Ascending cholangitis
Charcot triad - jaundice, RUQ, Fever Gallstones E coli
559
Ascending cholangtiis vs cholecystitis
Cholan - charcot triad chole - murphys
560
Diethylene glycol tox/OD tx
IV ethanol haemodialysis
561
Tropical med, non specific sx, eosinophilia
helminth/hookworm
562
Biventricular hypertrophy on ECG
VSD
563
What type of renal disease is Churg strauss and wegeners
focal segmental glomerulonephritis
564
MRI: increased signal in pulvinar of thalamus
CJD
565
Hyperoxaluria/uric oxalate renal stones tx
calcium supplemements
566
Impaired memory/planning inappropriate behaviour diminishing speech
fronto temporal dementia
567
Etanacerpt
anti TNF alpha CI in MS. TB
568
MS CF
oligoclonal bans raised IgG
569
TB drug course length
TB meningitis 12 months everything else 6 months
570
Signet ring cells
adenocarcinoma
571
MOA bupropion
Noradrenaline dopamine reuptake inhibitor
572
Topiramate side effects
weight loss, renal stones, behaviour change
573
mechanism of pedal edema in ccf
increased renin
574
Bronchial carcinoma tumour marker
Chromogranin A
575
Recurrent infections spanish immunoglobuin deficiency
IgD deficiency
576
Kearn sayre syndrome
sensineural hearing loss mitochondrial atazia stroke retinitis pgimentose cardiomypathy diabetes
577
Usher syndrome
retinitis pigmentose, hearing loss
578
What des BCR ABL code for
tyrosine kinase
579
Meds causing torticollis or acute dystonia
Prochloperazine, metocloperamide
580
Nerve root - weakness of thumb, numbness first web space
Radial nerve
581
NMS tx
dantrolene
582
Tx paraneoplastic pemphigous
steroids
583
SE carbimazole
rash pruritis arthalgia alopecia agranucytosis jaundice
584
Lyme disease test
Borrelia IgG
585
Irregular plauqe like lesion chronic progressive indurated foreign
Lupus vulgaris
586
Annular rimmed lesion with punched out hypopigmented centre
Borderline leprosy
587
Gold standard bronchiectasis diagnosis
HRCT
588
ECGs sign of impending cardiac arrest hyperkalaemia
prolonged QRS
589
Tx Neisseria mengitis
Ceftriaxone
590
RF Ig?
IgM
591
Why do people with CLL need irradiated blood?
Depletion of donor white cells
592
Where does 4th heart sounds sit on ECG
After P wave
593
Night sweats, lethargy, penumonia sx, hypercalcaemia
pulmonary sarcoid
594
Tx for lupus
hydroxchloroquine life threatening: cyclophosphamide lupus nephritis: mycophenolate mofteil
595
Tx necrobiosis lipoidica
Topical corticosteroids
596
Goes into VT whilst pacemaker - where had been touched?
coronary sinus
597
Tx Whipples disease
IV cef
598
mucosa appeared yellowed externally with erythematous erosions
Whipples
599
Dx ank spond if active sx
MRI sacro iliac
600
Pericarditis ECG
Saddle shaped ST most leads
601
Bone issue: High ALP low phos Lowish Ca High PTH
Osteomalacia
602
Pagets disease bloods
isolated ALP rise
603
Docetaxel renal impairment toxicity
renal tubular toxicity
604
MOZ tocilizumab
Anti IL 6
605
Tx for nephrogenic DI
hydrochlorthiazide
606
MOA baclofen
GABA agonist
607
Antibodies causing neonatal heart block
Anti RO, anti La
608
Tx syphilis
penicillin, doxy, azithro
609
Diabetic med good for heart failure/ CV health
dapagliflozin
610
SE pyrazinamide
joint pain hepatitis fever
611
SE rifampicin
thrombocytopaenia, nausea, vom
612
Cahnce of sibling being a HLA match
25%
613
Best anti hypertensives if on lithium
Ca channel blockers
614
2st step DKA tx
fluids
615
Scale for assessing ALDs
Barthel
616
Muscle causing fixed flexion deformity
rectus femoris
617
Virus causing anal cancer
HPV
618
Tx for Crohns skin/stoma ulcers
SC infliximab
619
Eplenerone site kidney
Distal PCT
620
1st line tx urgent thryoid eye disease
IV methylpred
621
Toxin causing heptaocellular carcinoma
aflatoxin
622
Positive urine nitroprusside hexagon shaped crystals on urine analysis
cystine stones
623
Boil breaking down to large painful ulcers
pyoderma gangrenosum
624
Mechanisms of haemolysis in G6PD
Reduced NADPH
625
When is 3rd nerve palsy likely compressive
pupil inovolvement
626
Porphyrias skin AND abdo
variegate porphyria
627
How long after increasing phenytoin should you check levels
2 weeks
628
MOA etanercept
TNF alpha
629
headache, fever myalgia, rash with black centre
mediterrean spotted fever
630
Can't sit still
Akthasia
631
Antidote to beta blocker overdose
IV glucagon
632
dehydration, sthen seizure, then focal neurology
saggital sinus thrombosis
633
Study type that has biggest issue with recall bias
case-control
634
Palm/sole melanoma
acral lentigous
635
Sun exposed area melanoma
Lentigo maligna
636
Which polyarteritis isnt ANCA +ve
polyarteritis nodosa
637
Tropical med + raised Right hemidiaphragmm
amoebic liver abcess
638
Life threatening warfarin bleed tx
Prothrmobin complex and vit K
639
Renal disease caused by NSAID
Interstitial nephritis
640
Pneumonia causing haemolytic anaemia
Mycoplasma
