MS and GBS

Question 1

Define multiple sclerosis

Answer 1

• CNS inflammatory disease of white matter disseminated over space and time
• Demyelination

Question 2

MC form of MS

Answer 2

Relapsing remitting

Question 3

Demographics of MS patients

Answer 3

• Onset at 15-45 yo
• 70% females
• More Northern hemisphere

Question 4

Describe relapsing-remitting MS

Answer 4

Episodes of acute worsening with recovery and a stable course b/w relapses

Question 5

Clinical presentation of MS

Answer 5

• Earliest signs are a young person tripping over curbs or sidewalks
• Heaviness or numbness of both legs

Question 6

Which neuro disorder is associated with optic neuritis?

Answer 6

MS

Question 7

How to diagnose MS?

Answer 7

• 2010 McDonald Criteria

- MRI (gold)

Question 8

What is required to diagnose MS?

Answer 8

At least 2 attacks (new s/s lasting for at least 24 hrs)

Question 9

Treatment of MS

Answer 9

• IV steroids (anti-inflamm)
• Immunomodulating or suppressing drugs
• Symptomatic treatment

Question 10

Management of MS relapse

Answer 10

High dose steroids

Question 11

What kind of disease is Guillain-Barre syndrome?

Answer 11

Immune-mediated neuroapthy

Question 12

Clinical presentation of GBS?

Answer 12

• Rapid, areflexic, ascending motor paralysis
• With or w/o sensory component
• Lower CNs often involved

Question 13

Etiology of GBS?

Answer 13

70% occur after an acute infectious process (Campylobacter, CMV, mycoplasma)

Question 14

What is required to diagnose GBS?

Answer 14

1. Progressive weakness

2. Generalized hypo or areflexia

Question 15

Treatment of GBS

Answer 15

High dose IVIG or plasmapheresis