MS Endocrine

Question 1

Usual COD of Diabetes Insipidus (2)

Answer 1

Dehydration & Hypovolemic Shock (Vascular)

Question 2

☆ Leading cause of SIADH

Answer 2

Adenoma in hypothalamus or PPG

Question 3

Usual COD of SIADH (2)

Answer 3

Seizures & Arrhythmia

Question 4

WOF in SIADH

Answer 4

Dilutional Hyponatremia

This can cause arrhythmia (brady / AV block) and seizures

Question 5

DOC for DI

Answer 5

Lifetime HRT of ADH (-pressin)

Emergency: IV, IM
Maintenance: Intranasal / Oral

Question 6

DOC for SIADH

Answer 6

Demeclocyline

• decreases ADH production

Question 7

Drug used for DI which stimulates ADH release (neuro) and lowers resistance to ADH (nephro)

Answer 7

Chlorpropramide (Diabenase)

Question 8

Type of diuretics preferred in SIADH

Answer 8

Loop Diuretics

(Decreased K = Increased Na)

Question 9

Leading cause of hypoparathyroidism

Answer 9

Autoimmune

Question 10

Leading cause of hyperparathyroidism

Answer 10

Adenoma in PTG

Question 11

WOF in Hypoparathyroidism

Answer 11

Laryngospasm & Bronchospasm

Question 12

DOC for Hypoparathyroidism

Answer 12

HRT of PTH for Life

Question 13

DOC for hyperparathyroidism

Answer 13

Calcitonin

Question 14

☆ Drug for hypoparathyroidism

Answer 14

Aluminum Hydroxide (Amphogel)

• Form of antacid; a phosphate binder. Excessive phosphorus in blood is delivered to stool to be excreted.

Decreased PHO = Increased Ca

Question 15

Hormone responsible for withdrawal of calcium to bone

Answer 15

Parathyroid Hormone / Parat Hormone

Question 16

Hormone responsible for depositing calcium in blood to bone

Answer 16

Thyrocalcitonin

Question 17

Leading cause of primary hypothyroidism

Answer 17

Autoimmune

Hashimoto / Autoimmune Thyroiditis

Question 18

☆ Leading cause of primary hyperthyroidism

Answer 18

Autoimmune Irritation

Question 19

Earliest sign of hypothyroidism

Answer 19

Fatigue / Weakness / Body Malaise

Question 20

Earliest Sx of Hyperthyroidism

Answer 20

Shakiness / tremors starting at the hands

Question 21

WOF in Hyperthyroidism

Answer 21

Risk for Airway Obstruction (Goiter)

Dalyrymple’s Sign (Thyroid Stare)
- red eyes, infrequent blinking

Von Graefe’s Sign (Lid-Lag Sign)

Question 22

☆ WOF in Hypothyroidism

Answer 22

Myxedema Coma

Question 23

☆ WOF in Hyperthyroidism

Answer 23

Thyrotoxic Crisis (Thyroid Storm)

Question 24

Early sign of thyrotoxic crisis

Answer 24

Constant elevation of HR and temperature

Question 25

Best Dx Test for Hypo and hyperthyroidism

Answer 25

Needle Biopsy (FNA) ☆ RAIU / Thyroid Scan ☆

Question 26

In RAIU, what is given to check?

Answer 26

Low Dose of Sodium Iodide 123 Sodium 131 = Treatment = High Dose

Question 27

Type of antihypertensive drugs to be used for hyperthyroidism

Answer 27

Beta Blocker & DiVe of CCB (-) Chromo, Dromo, Ino

Question 28

Contraindicated antipyretic for hyperthyroidism

Answer 28

Salicylate based because it has the ability to increase T3 and T4

Question 29

☆ Solution used for hyperthyroidism

Answer 29

Lugol's Solution (Saturated Potassium Iodine / SSKI) - Decreases size and vasculrity of thyroid - Use STRAW to prevent deep staining

Question 30

☆ DOC for hyperthyroidism

Answer 30

Tapazole, Methimazole, PTU (Most Potent)

Question 31

A/E of PTU (Prophylthiouracil)

Answer 31

Agranulocytosis / Blood Dycrasia WOF: Sore Throat + Fever

Question 32

☆ WOF: Thyroidectomy Post-Op Complications ☆

Answer 32

- Airway Obstruction (Bedsite ET) - Bleeding / Hemorrhage - Hypocalcemia (Calcium Gluconate at Bedside) - Laryngeal Nerve Damage (Hoarseness of voice is normal for 1-6 weeks; no voice when speaking is abnormal) ☆ - Thyroid Storm

Question 33

Straw Drugs

Answer 33

LITT - Lugol's - Iron - Tetracycline - Thorazine / Chlorpromazine