MSK Flashcards
1
Q
What are the indications for colchicine?
A
It is second line treatment for gout
2
Q
What is the mechanism of action for colchicine?
A
- disrupts tubulin leading to the down regulation of multiple inflammatory pathways
- also leads to down regulation of innate immunity
- inhibits phagocytosis
- inhibits leukocyte migration to joints
- decreases the release of uric acid
3
Q
When should colchicine be used with caution?
A
- cardiac disease
- the elderly
- GI disease
4
Q
What are the common side effects of colchicine
A
- abdo pain
- diarrhoea
- nausea
- vomiting
