MSK

Question 1

osteoarthritis

Answer 1

paracetamol, if not working give topical NSAIDs

Question 2

NSAIDs

Answer 2

reversibly (apart from aspirin, which irreversibly inhibits COX1) inhibit COX2 enzyme, necessary for prostaglandins
- ADRs = from COX1 inhibition

Question 3

Paracetamol

Answer 3

pain relief, not anti-inflammatory, only works in CNS so blocks pain conduction

Question 4

How to treat RA?

Answer 4

NSAIDs good for symptomatic relief (explain to them they shouldn’t take all the time), prednisolone for flare ups - can’t be given for long. First line is DMARDs - methotrexate,, sulfalsalazine
Biological agents = if methotrexate isn’t working; inflictamab

Question 5

Infliximab

Answer 5

an anti-TNF, therefore has ADRs; serious infection, TB reactivation, Hep B