MSK Flashcards

Question

DDx of polyostotic lesions of Paget’s

Answer 1

``` chronic renal failure (hyperparathyroidism) Langerhans cells histiocytosis unusual infection metastasis fibrous dysplasia lymphoma Gaucher mastocytosis ```

Answer 2

glomus tumour mets (above diaphragm: lung, breast) inclusion cyst (less aggressive) enchondroma (MC lytic lesion in phalanx but terminal phalanx is least common site)

Answer 3

enchondroma low grade chondrosarcoma bone infarct

Answer 4

Langerhans cell histiocytosis osteoid osteoma Brodie abscess

Answer 5

``` arthritis infection PVNS synovial chondromatosis amyloidosis ```

Answer 6

hyperparathyroidism polyvinyl chloride Hajdu-Cheney syndrome Post traumatic

Answer 7

``` infection - pyogenic - TB sickle cell anemia (50% of children) thermal injury ```

Answer 8

``` Turner syndrome pseudopseudohypoparathyroidism post infection, trauma JIA idiopathic ```

Answer 9

``` gout xanthomatosis sarcoidosis amyloidosis multicentric reticulohistiocytosis ```

Answer 10

``` myositis ossificans gout collagen vascular disease hyperparathyroidism, tumoral calcinosis hemangioma soft tissue chondro/osteosarcoma synovial sarcoma ```

Answer 11

tumoral calcinosis | milk alkali syndrome

Answer 12

``` GCT/ABC metastasis myeloma/plasmacytoma chordoma neurogenic tumour ```

Answer 13

``` Myelofibrosis Fluorosis Pyknodysostosis Metastatic disease Renal osteodystrophy Osteopetrosis Mastocytosis ```

Answer 14

(segmental area of decreased bone mineral density) disuse (immobilization) chronic regional pain syndrome (CRPS), reflex sympathetic dystrophy (RSD) transient osteoporosis (bone marrow edema) regional migratory osteoporosis

Answer 15

chronic anemia (sickle cell disease) Gaucher disease osteopetrosis fibrous dysplasia Niemann-Pick (enzyme deficiency, storage disorder of sphingolipidoses) metaphyseal dysplasia (Pyle’s disease, SFRP4 gene mutation, diffuse long bone abN)

Answer 16

``` STOP HH sickle cell disease thoratrast administration osteopetrosis Paget disease heavy metal poisoning hypervitaminosis D ```

Answer 17

PRINCES Poisoning (lead, mercury, bismuth, phosphorus) Rickets (healed) Infection (TORCH); Idiopathic hypercalcemia Normal variant; Neoplasm (leukemia) Congenital syphilis Endocrine (congenital hypothyroidism [cretinism]) Sickle cell disease; Scurvy

Answer 18

LINING ``` Leukemia, lymphoma Infection (congenital syphilis) Normal variant Illness (systemic: rickets, scurvy) Neuroblastoma metastatses Growth arrest lines ```

Answer 19

CHARMS ``` Congenital infections (rubella, syphilis) Hypophosphatasia Achondroplasia Rickets Metaphyseal dysostosis Scurvy ```

Answer 20

``` leukemia diffuse skeletal mets reconversion myelofibrosis myelodysplastic syndrome mastocytosis hemochromatosis Gaucher renal osteodystrophy gout, sarcoidosis, amyloidosis ```

Answer 21

``` any lesion with assoc fracture abscess osteoid osteoma chondroblastoma Langerhans cell histiocytosis lymphoma ```

Answer 22

metastatic (elevated Ca2+ x PO4 causing precipitation of a calcium salt) - skeletal deossification - primary hyperparathyroidism - renal osteodystrophy - bone destruction - hypervitaminosis D - milk alkali syndrome dystrophic (tissue damaged, normal Ca2+, PO4 levels) - trauma (incl. repetitive leading to calcific tendinosis) - infection - tumour (e.g. chondroid, osteoid producing) - vessel or vascular malformation - collagen vascular disease: scleroderma, SLE, dermatomyositis, polymyositis idiopathic (elevated PO4) - calcinosis universalis - tumoral calcinosis

Answer 23

``` PVNS gout amyloid synovial chondromatosis hemophilic arthropathy (hemorrhagic synovitis) ```

Answer 24

rickets hypophosphatasia metaphyseal dysostosis

Answer 25

``` rheumatoid arthritis other inflammatory arthropathies infection hemophilia CPPD ```

Answer 26

achondroplasia | thanatophoric dysplasia

MSK Flashcards

(50 cards)