mtap hema2 Flashcards
(124 cards)
1
Q
Where are the coagulation factors produced?
A
LIVER
2
Q
The only 2 coag factors not produced in the liver
A
3, 4
3
Q
vWF is made by _____ & _____
A
Megakaryocytes
Endothelial cells
4
Q
True or False:
Factor VIII has the shortest half-life
A
FALSE
Factor VII = 6 hours
5
Q
2 coag factors transmitted as X-linked recessive
A
8, 9
6
Q
All deficiencies of coag factors are transmitted as: ____
A
Autosomal recessive
7
Q
The most concentrated of all the plasma procoagulants
A
Factor I - Fibrinogen
8
Q
Deficiency of GP IIb/IIIa
A
Glanzmann’s thrombasthenia
9
Q
Why is there no such thing as Factor III deficiency?
A
It comes from the tissues
10
Q
Factor IV is chelated by ____ & _____
A
EDTA
Sodium citrate
11
Q
Mutant Factor V
A
Factor V Leiden
12
Q
Factor V names (3)
A
Proaccelerin
Labile Factor
Thrombogen
13
Q
True or False:
Factor V Leiden is not inactivated by protein C-protein S complex
A
True
14
Q
Factor V deficiency
A
Owren’s disease / Parahemophilia
15
Q
First clotting factor affected by WARFARIN therapy
A
Factor VII
Proconvertin / Stable factor
16
Q
Factor VIII names (2)
A
Antihemophilic Factor A
Antihemophilic Globulin
17
Q
Factor VIII def.
A
Hemophilia A
Classic hemophilia
18
Q
Refers to the Procoagulant portion of Factor VIII
A
VIII:C
19
Q
Refers to the antigenic properties of Factor VIII
A
VIII:Ag
20
Q
RCo in Factor VIII means:
A
Ristocetin cofactor
21
Q
True or False:
vWF is required for normal platelet aggregation
A
False
Adhesion
22
Q
vWF has receptor sites for both _____ & ______
A
Collagen
Platelets
23
Q
Largest molecule in the human plasma
A
vWF
24
Q
Platelet surface receptor for vWF
A
GP Ib/IX/V
25
Plasma Thromboplastin Component is Factor ___?
9
26
Factor IX def.
Hemophilia B
| Christmas disease
27
Stuart-Prower Factor is factor ___?
10
28
Plasma thromboplastin antecedent is what factor?
11
29
Factor XI def.
Hemophilia C
| Rosenthal syndrome
30
This deficiency is seen in ASHKENAZI JEWS
Hemophilia C (factor 11)
31
has no bleeding tendency, but with thrombotic tendency
Factor 12
32
Factor XII names (3)
Hageman Factor
Glass factor
Contact factor
33
Prekallikrein is also known as
Fletcher factor
34
HMWK names (4)
Reid
Williams
Fitzgerald
Flaujeac
35
Zymogens are?
coag factor enzymes that circulate in an inactive form
36
7 Serine proteases
2, 7, 9, 10, 11, 12, PK
37
coag factors that function as Cofactors (4)
3, 5, 8, HMWK
38
8 coag factor zymogens
2, 7, 9, 10, 11, 12, PK, 13
39
Intrinsic pathway (4)
12, 11, 9, 8
40
Extrinsic pathway (2)
3, 7
41
Common pathway (4)
10, 5, 2, 1
42
Fibrinogen group is also known as ____
Thrombin sensitive group
43
Coag factors in FIBRINOGEN group (4)
1, 5, 8, 13
44
Coag factors in PROTHROMBIN group (4)
2, 7, 9, 10
45
Coag factors in CONTACT group (4)
12, 11, PK, HMWK
46
Factor XIII names (3)
Fibrin stabilizing factor
Fibrinase
Laki-Lorand factor
47
Test used in Factor XIII def
5M Urea Clot Solubility Test / Duckert's test
48
True or False:
| If clot is INSOLUBLE to 5M urea = there is factor XIII def
False
| Soluble
49
Vit K independent
| Calcium dependent
Fibrinogen group
50
Fibrinogen group is in increased in ___, ____, ____, ____
Pregnancy
Inflammation
Stress
Oral contraceptive
51
Vit K dependent
| Calcium dependent
Prothrombin group
52
The only group that cannot be made by the liver without Vit K
Prothrombin group
53
Vitamin K independent
| Calcium independent
Contact group
54
Prothrombin group is adsorb from plasma using:
1. ______
2. ______
Barium sulfate
| Aluminum hydroxide
55
2 phases of IN VIVO coagulation
Initiation
| Propagation
56
Where does the Initiation phase occur?
Tissue factor-bearing cells
57
Where does the Propagation phase occur?
Platelets
58
True or False:
| Calcium is involved in all phases of coagulation except in CONTACT phase
TRUE
59
ref range for APTT
35-45 seconds
60
What does it mean when you say "ACTIVATED" PTT
negatively charged activators are added
61
Examples of activators: (5)
```
Silica
Kaolin
Celite
Bentonite
Soluble activator (Ellagic acid)
```
62
Common test used for monitoring heparin therapy
APTT
63
APTT detects deficiencies in what pathway? (2)
Common
| Intrinsic
64
How much Platelet-poor plasma is added to the APTT reagent?
A. 0.01 mL
B. 1.00 mL
C. 0.1 mL
C. 0.1 mL
65
This test has a ref range of 10-13 seconds
PT
66
This test is used for monitoring Warfarin therapy
PT
67
Prothrombin time detects deficiencies in what pathway? (2)
Common
| Extrinsic
68
Standardized way of reporting PT
INR
69
PT of patient divided by the mean of ref range multiplied by 100
Prothrombin ratio
70
Meaning of WARF
Wisconsin Alumni Research Foundation
71
Warfarin inhibits the synthesis of what coag factors (4)
2, 7, 9, 10
72
It neutralizes the effect of Vitamin K
Warfarin
73
Used for overdosage of Heparin
Protamin sulfate
74
It is a common intravenous anticoag
Heparin
75
It is routinely used in cardiac surgery
UFH
76
A point of care assay used in clinics, bedside, cardiac catheterization, surgical suite
ACT - activated coagulation time
77
It has a lower incidence of heparin induced thrombocytopenia compared with UFH
LMWH
78
Coagulation instrumentation (5 principles)
```
Mechanical/Electromechanical
Turbidometric (Photo-optical)
Nephelometric
Chromogenic
Immunologic
```
79
This principle detects a change in plasma optical density
Trubidometric (photo-optical)
80
This principle uses synthetic oligopeptide substrate conjugated to a chromophore
Chromogenic
81
Contains all coagulation factors
| Except: 5, 8
Aged plasma
82
Contains all coagulation factors
| Except: 1, 5, 8, 13, 2
Aged serum
83
Contains all coagulation factors
| Except: 2, 7, 9, 10
Adsorbed plasma
84
Russel's viper venom time is also known as
Stypven time
85
This test is used to detect lupus anticoag
Dilute Russel's viper venom time
86
ref range for stypven time
20-25 seconds
87
2 tests used for fibrinogen deficiency
Thrombin time
| Reptilase time
88
This test uses the venom of Bothrops atrax
Reptilase time
89
True or False:
| Thrombin time is unaffected by heparin
FALSE
| Reptilase time
90
True or False:
| Heparin therapy is prolonged in Thrombin time
TRUE
91
2 Methods of Clotting time
Slide/Drop method
| Lee and White/Whole blood clotting time
92
This test has a ref range of 2-4 minutes
Slide/Drop method
93
PT: Prolonged
APTT: Normal
TT: Normal
PLT: Normal
A. Factor XIII def
B. Liver disease
C. Proconvertin def
D. DIC
C. Proconvertin def (factor 7)
94
PT: Normal
APTT: Normal
TT: Normal
PLT: Decreased
A. Fibrinogen def
B. Thrombocytopenia
C. Hemophilia A
B. Thrombocytopenia
95
This drug shortens APTT
A. Isoniazid
B. DDAVP
C. Penicillin G
B. DDAVP
1-desamino-8- D-arginine vasopressin
96
This drug enhances the effect of Warfarin (2 answers)
A. Phenylbutazone
B. Streptomycin
C. Aspirin
D. Metronidazole
A. Phenylbutazone
| D. Metronidazole
97
Stimulates formation of inhibitors to Labile factor
A. Isoniazid
B. Streptomycin
C. Metronidazole
B. Streptomycin
Labile factor = factor 5
98
This drug weakens interaction of vWF with platelets
A. Penicillin G
B. Aspirin
C. Phenothiazines
A. Penicillin G
99
Stimulates the production of a lupus anticoag
A. Streptomycin
B. Phenothiazines
C. Isoniazid
B. Phenothiazines
100
Can produce thombocytopenia
A. Isoniazid
B. Aspirin
C. DDAVP
A. Isoniazid
101
These are acquired inhibitors of coagulation
Circulating anticoag/inhibitors
102
Most common Specific inhibitors
Factor 8,9
103
Examples of Non-specific inhibitors (3)
Lupus anticoag
Paraproteins
Fibrinogen degradation products
104
Main serine protease inhibitor
Antithrombin
105
2 Major anticoag in the body
Protein C/Protein S System
| Plasma Serine Protease Inhibitor System
106
Final stage of coagulation and is the dissolution of clot
Fibrinolysis
107
2 activators of fibrinolysis released during inflammation and coagulation
TPA - Tissue plasminogen activator
| UPA - Urokinase plasminogen activator
108
Proteins that accumulate into fibrin clot (5)
```
Plasminogen
TPA
UPA
PAI-1
TAFI
A2-Antiplasmin
```
109
Plasma zymogen
Plasminogen
110
Plasminogen is stored and transported by what cells
Eosinophils
111
May cause a potentially deadly primary fibrinolysis
Free Plasmin
112
Activates plasminogen
TPA - Tissue plasminogen activator
113
UPA is secreted by what cells (3)
Urinary tract epithelial cells
Monocytes
Macrophages
114
Principal inhibitor of plasminogen activation
PAI-1 - Plasminogen Activator Inhibitor
115
Primary inhibitor of free plasmin
A2-antiplasmin
116
TAFI stands for
Thrombin-Activatable Fibrinolysis Inhibitor
117
TAFI is activated by what complex?
Thrombin-thrombomodulin complex
118
2 tests for Fibrinolysis
D-dimer
| Euglobulin lysis time
119
It indicates that a stable fibrin clot has been lysed
D-dimer
120
FDP: +
| D-dimer: -
Pathological fibrinolysis
121
FDP: +
| D-dimer: +
DIC - disseminated intravascular coagulation
122
Proteins that precipitate when plasma is
| diluted with water and acidified
Euglobulin
123
Normal value for Euglobulin lysis time
>2 hours
124
Euglobulin is acidified using
1% acetic acid
