MTB - Allergology/Immunology Flashcards Preview

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Flashcards in MTB - Allergology/Immunology Deck (23):
1

initial therapy - anaphylaxis

1. subcutaneous Epi. 1:1000 conc
2. corticosteroids
3. H1-antagonist antihistamines (diphenhydramine or hydroxyzine)

2

sudden swelling of the face, palate, tongue and airway in assoc. w/ minor trauma to the face or hands OR ingestion of ACE inhibitors

angioedema

3

hereditary angioedema

C1 esterase inhibitor deficiency

4

assoc. symptoms with angioedema

stridor
abdominal pain
lack of response to steroids

5

diagnosis of angioedema

low levels of C2 and C4 complement

6

Tx. of acute episodes of angioedema

infusion of FFP

7

DOC for hereditary angioedema

ecallantide

8

Ecallantide

inhibitor of kallikrein; blocks bradykinin production

9

what drug class may be used for chronic therapy of angioedema

androgens - danazol, stanazol
- raise levels of C1 esterase inhibitor

10

CCS - patient comes in with signs of anaphylaxis after insect bite w/ no improvement after Epi injection, steroids or H1 blockers - > what do you do?

admit patient to ICU

11

when desensitizing a patient to a drug what other drugs should be stopped?

propranolol and all B-Blockers should be stopped prior to attempting desensitization (in case Epi needs to be used)

12

Symptoms of Allergic Rhinitis

recurrent episodes of nasal itching
nasal stuffiness
rhinorrhea
paroxysms of sneezing
eye itching
dermatitis
wheezing

13

DOC allergic rhinitis

intranasal steroids
- single most effective tx

14

Aside from intranasal steroids, what other therapies may be used for allergic rhinitis?

antihistamines (oral, intranasal)
cromolyn
ipratroprium bromide
LT inhibitors
nasal saline spray and wash

15

older man presents with recurrent episodes of sinopulmonary infections and a sprue-like abdominal disorder; he has enlarged LN and splenomegaly - dx?

Common variable immune deficiency

16

diagnostic testing - CVID

low levels of total IgG
(B and T cells are present but do not make enough antibody)

17

Tx. CVID

infusion of IV immunoglobulins

18

young male child presents with recurrent sinopulmonary infections - dx?

X-linked agammaglobulinemia
- no B cells = no Ig
- LN, adenoids and spleen are diminished or absent

19

MC primary immunodeficiency

IgA deficiency

20

CF: IgA deficiency

mostly asx
recurrent sinopulmonary infections
sprue-like malabsorption
increased incidence of atopic conditions
anaphylaxis w/ blood products

21

Tx. IgA deficiency

tx. infections as they arise
IVIG will not work as there is little IgA in it

22

patient comes in w/ recurrent skin infections caused by Staphylococcus

hyper IgE syndrome

23

Tx. hyper IgE syndrome

tx. infections as they arise