Flashcards in Mucosal immunity basic science Deck (10):
What are the mucosal tissues of the GI tract?
What are physiological functions of mucosal tissue?
Where is the germinal centre found in a lymph node?
In the secondary lymphoid follicle
Where are intestinal lymphocytes found?
In organised tissues where immune responses are induced, and scattered throughout the intestine, where they carry out effector functions.
What the name of the specialised lymph node which sites in the epithelium fo the small intestine?
Is the lamina propria part of induced immune responses or effector functions?
effector mechanisms - T cells, macrophages, dendritic, B cells etc.
Where does the lymph from the small intestine drain to?
mesenteric lymph node
Describe the structure of Peyer's patches.
Sub-epithelial dome covered in epithelial layer containing specialised M cells.
Dendritic cells sit directly underneath dome next to M cells
What are the dendritic cells of Peyer's patches doing?
sit directly under M cells - constantly sampling antigens from M cells, processing and presenting MHC on its surface