Mucosal immunity basic science Flashcards Preview

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Flashcards in Mucosal immunity basic science Deck (10):
1

What are the mucosal tissues of the GI tract?

oral cavity
oesophagus
stomach
intestine

2

What are physiological functions of mucosal tissue?

gas exchange
food adhesion
sensory activities
reproduction

3

Where is the germinal centre found in a lymph node?

In the secondary lymphoid follicle

4

Where are intestinal lymphocytes found?

In organised tissues where immune responses are induced, and scattered throughout the intestine, where they carry out effector functions.

5

What the name of the specialised lymph node which sites in the epithelium fo the small intestine?

Peyer's patch

6

Is the lamina propria part of induced immune responses or effector functions?

effector mechanisms - T cells, macrophages, dendritic, B cells etc.

7

Where does the lymph from the small intestine drain to?

mesenteric lymph node

8

Describe the structure of Peyer's patches.

Sub-epithelial dome covered in epithelial layer containing specialised M cells.
Dendritic cells sit directly underneath dome next to M cells

9

What are the dendritic cells of Peyer's patches doing?

sit directly under M cells - constantly sampling antigens from M cells, processing and presenting MHC on its surface

10

What is the function of Peyer's patches?

to analyse and respond to pathogenic microbes in the ileum