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Flashcards in Multiple Systems Deck (17):
1

What are the skin changes in lupus?

Butterfly rash (spares nasolabial folds)
Discoid rash
Photosensitivity
Non- scarring alopecia
Livido

2

Antibodies in SLE

Ana
Anti Dsdna

3

Dry mucous membranes and joint pain?

Sjogrens

4

Anti bodies in sjogrens?

Ana
Ro
La
Rheumatoid factor

5

Signs and symptoms of limited cutaneous systemic sclerosis

Calcinosis
Raynauds
Oesophageal dysfunction
Scerodsctly
Telengiectasis
(CREST)
And pulmonary arterial hypertension

6

Antibodies in limited cutaneous systemic sclerosis?

Ana
Anti centromere antibody

7

Antibodies in diffuse systemic sclerosis

Ana
Anti- scl70
(Anti topoisomerase)

8

What are the features of diffuse scleroderma?

Lung (pulmonary hypertension), heart (right sided heart failure), GI and kidney (renal crisis: malignant hypertension, high renin, azotemia, microangiopathic haemolytic anaemia, haematuria/protienuria ) involvement

9

What is seen on bloods in antiphospholipid syndrome?

Paradoxical (Long) APTT
Low platelets

10

Which disease in AMA antibody associated with?

Primary biliary cirrhosis

11

Which cancers are associated with dermatomyositis?

Ovarian, breast, lung found in 20-25% of patients.

Needs investigations esp in older people.

12

What features are seen in bechets?

Mouth and genital ulcers
Skin lesions (Erythema nodosum)
Opthalmic lesions (uveitis or retinitis)

Cerebral vasculitis (head, seizures)
Arthritis and IBD symptoms
Raised CRP and ESR




13

What is libman-Sachs endocarditis?

Sterile endocarditis associated with SLE

14

Anti- smith antibodies?

Pathopneumonic for SLE

15

Diffuse systemic sclerosis features

Pulmonary

Gut

Renal - Rx with ace and dialysis

16

Rx of Sjögren's syndrome

Hydroxychloraquine
Pilocarpine

Plus lubrication
Monitor for lymphoma

17

First line treatment for SLE ?

Hydroxychloroquine (good for mucocutaneous disease)

DMARDs for more aggressive disease