Flashcards in Multiple Systems Deck (17):
What are the skin changes in lupus?
Butterfly rash (spares nasolabial folds)
Non- scarring alopecia
Antibodies in SLE
Dry mucous membranes and joint pain?
Anti bodies in sjogrens?
Signs and symptoms of limited cutaneous systemic sclerosis
And pulmonary arterial hypertension
Antibodies in limited cutaneous systemic sclerosis?
Anti centromere antibody
Antibodies in diffuse systemic sclerosis
What are the features of diffuse scleroderma?
Lung (pulmonary hypertension), heart (right sided heart failure), GI and kidney (renal crisis: malignant hypertension, high renin, azotemia, microangiopathic haemolytic anaemia, haematuria/protienuria ) involvement
What is seen on bloods in antiphospholipid syndrome?
Paradoxical (Long) APTT
Which disease in AMA antibody associated with?
Primary biliary cirrhosis
Which cancers are associated with dermatomyositis?
Ovarian, breast, lung found in 20-25% of patients.
Needs investigations esp in older people.
What features are seen in bechets?
Mouth and genital ulcers
Skin lesions (Erythema nodosum)
Opthalmic lesions (uveitis or retinitis)
Cerebral vasculitis (head, seizures)
Arthritis and IBD symptoms
Raised CRP and ESR
What is libman-Sachs endocarditis?
Sterile endocarditis associated with SLE
Anti- smith antibodies?
Pathopneumonic for SLE
Diffuse systemic sclerosis features
Renal - Rx with ace and dialysis
Rx of Sjögren's syndrome
Monitor for lymphoma