Muscle Relaxants Flashcards
1
Q
What are the functions of Central-acting muscle relaxants?
A
- Direct (work on contractile mechanism of skeletal musculature)
- Transmission in spinal cord reflex pathways (elicit varying degrees of skeletal muscle relaxation)
2
Q
What is the GOAL of TX CENTRAL-acting skeletal muscle relaxant?
A
Produce DEC muscle tone and involuntary movement without loss of voluntary muscle function/consciousness
3
Q
What medications are utilized as CENTRAL-acting skeletal muscle agents? (4)
A
- Cyclobenzaprine
- Baclofen
- Tizanidine
- Carisoprodol
4
Q
What are ADRs of CENTRAL-acting Skeletal Muscle Relaxants?
A
- Drowsiness
- Xerostomia
- N/V (Baclofen-specific)
5
Q
What medications are utilized as Peripheral-acting Skeletal Muscle Relaxants?
A
Neuromuscular Blocking Agents
- Succinylcholine
- Vecuronium
6
Q
How do Peripheral-acting Skeletal Muscle Relaxants function?
A
- Interfere with transmission of cholinergic impulses at NMJ
- Produce paralysis of involved skeletal muscles
- Primarily utilized as adjunct TX general anesthesia
