Mutations Flashcards
1
Q
8;21
A
AML
2
Q
15;17
A
APL
3
Q
12;21
A
children’s ALL
4
Q
9;22
A
PH+, either CML or B-all adult
5
Q
CD5+
A
Increased in CLL
6
Q
TRAP
A
Positive with hair cell leukemia
7
Q
Rash Leukemia
A
Adult T Cell Leukemia
8
Q
617 exon 4
A
PV
9
Q
Pruritis
A
PV
10
Q
LAP-
A
CML
11
Q
CARL+
A
ET or primary myelofibrosis
12
Q
CD30+
A
Hodgkins Lymphoma
13
Q
ABVD risk
A
Coronary artery disease
14
Q
Hodgkins staging
A
Ann Arbor
15
Q
Lacunar cells
A
Nodular sclerosing
16
Q
14;18
A
BRC2 in Follicular NHL
17
Q
11;14
A
Cylcin D in Mantle NHL
18
Q
8;14
A
C-Myc in Burkitt’s
19
Q
Starry Sky
A
Burkitt’s
20
Q
Sheets of large B cells
A
DLBCL
21
Q
IL6
A
Multiple myeloma
22
Q
RANK
A
Multiple Myeloma
23
Q
IgM
A
Waldenstrom’s
24
Q
14q32
A
Multiple Myeloma
25
4;14
Multiple Myeloma, high risk
26
Birbeck Granule
Tennis racket, Langerhan's Cells
27
CD1A+ and S100+
Langerhan's Cells
28
drug causing hand-foot syndrome
Capecitabine, pyrimidine analog
29
drug causing Hemorrhagic Cystitis
Cyclophosphamade, DNA Alkylator
30
drug causing Cardiotoxicity
Doxorubicin
31
drug causing Pulmonary fibrosis
Bleomycin
32
drug causing early menopause-like symptoms
Tamoxifen
33
drug causing clotting
Bevacizumab
34
anti-CD30 drug
Brentuximab
35
CTLA-4 function
turn off T cell in "effector" stage
36
B7 paired with
CD28
37
PD1/PDL1
Turns off T cell
38
CTLA4 blocker name
ipilimumab
39
drug causing hepatitis
ipilimumab (anti CTLA4)
40
PD1 blocker name
nivolumab
41
drug causing arthralgias
nivolumab (anti-PD1)
42
RAR-a
APL
43
Type M3 AML
APL
44
CD11+
Hairy Cell Leukemia
45
CD10+
Follicular NHL
46
G1 to S phase
Due to Cylcin D mutation in Mantle NHL
47
Richter's Syndrome
SLL
48
3q27
DLBCL
49
Amyloidosis (primary)
Multiple Myeloma
50
Multiple myeloma tx
Thalidimide and bortezomib
51
Methyltrexate target
DHFR making TS
52
HER2 drug
trastuzimab
53
EGFR (2 drugs)
Erlotinib
| Certuximab
54
VEGF drug
bevicizumab
55
BRAF drug
verumafenib
56
Anti-CD30
Brentuximab
57
CD3+
Langerhan's (Letter-Siwe)
