Myco Flashcards
(23 cards)
This virus has matrix protein
Enveloped virus
This virus has no matrix protein
Naked protein
Small naked viruses
Positive sense, single stranded RNA virus
Cytoplasm is the site of replication
Picornaviridae
Genus: enterovirus
Causes: poliomyelitis
Transmission: oral fecal
Poliovirus
Genus: enterovirus
Causes: several diseases
Transmission: oral fecal, respiratory aerosols
Coxsakie virus
Herpangina
Hand foot and mouth disease
A16 disease
Group A
Pleurodynia
Bornholm disease
Myocarditis
Pericarditis
Group B coxsakie virus
Genus: Enterovirus
• Enteric Cytopathogenic Human Orphan
• Leading cause of aseptic meningitis
• Lab dx: Cell culture (Serological test not useful)
Echovirus
Formerly a Genus
• Infect nose and throat
• Agent of common colds
• Acid labile
• Grow better at 33°C
• Transmission: contact with contaminated hands
Human Rhino Virus A,B,C
Genus: Hepatovirus
• Formerly Hepatitis A virus
• Transmission: Oral-fecal route
• Very stable virus
• Can withstand 56-60°C for 1 hour
• Acid stable but can be destroyed by autoclaving and boiling
Hepatovirus A
Anti-HAV
• Detects total antibody
• Anti-HAV IgM
• Indicates recent infection (<6 months)
• HAV RNA
• Viral replication marker
Hepatitis A Serological Marker
Genus: Parechovirus
• Formerly Enterovirus 22
Human parechovirus A
Genus: Parechovirus
• Formerly Enterovirus 23
• Causes zoonotic infection (bank, vole, wild rodents)
• Associated with malformations, diabetes, intrauterine deaths and sudden infant deaths in human
Human parechovirus B or Ljungan virus
Genus: Kobuvirus
• Formerly Aichi virus
• Identified in 1989 outbreak of AGE in Aichi Prefecture
• Not much known about its epidemiology
• Oyster-related
• Aichi virus 1 – Human Kobuvirus
Aichivirus A
Formerly Reoviridae
• Respiratory Enteric Orphan
• Orphan – not associated with any known disease • Single stranded RNA virus
• First isolated in respiratory tract and enteric tract
Sedoreoviridae
Genus: Rotavirus
• Formerly Aichi virus
• Distinct wheel-shaped appearance
• Causes: upper and lower respiratory tract disease, gastroenteritis, diarrhea
• Transmission: Oral-fecal route
• Lab dx: Stool (RNA) or ELISA
Rotavirus (A,B,C,D,F,G,H,I,J)
*A – commonly causes diseases in Humans • A-I – causes diseases in other animals
•H – pigs
• D,F,G – birds
•I – cats •J – bats
Rotavirus
Calyx – Goblet
• Single stranded RNA virus positive sense
• Site of Replication: Cytoplasm
CALICIVIRIDAE
• Genus: Norovirus
• Cause outbreaks of AGE in schools and camps • Isolated in Norwalk village, Ohio
• Also known as Winter vomiting virus
• Transmission: Oral-fecal route, airborne
Norwalk virus
Genus: Sapovirus
• Humans and swine – natural hosts • Common cause of AGE
• Named after Sapporo, Japan
• Transmission: Oral-fecal route
Sapporo virus
Single stranded RNA virus positive sense
• Hepatitis E virus was once part of Caliciviridae and was transferred to this family
HEPEVIRIDAE
Genus: Orthohepevirus
• Causes: Hepatitis E
• Associated with Hepatitis C virus • First isolated in 1990
• Transmission: Oral-fecal route
• Lab dx: Western blot, EM, PCR
Orthohepevirus A or Hepatitis E virus
In a quasi-enveloped particle, the RNA and protein shell are completely enclosed within a membrane that is released from the host cell.
• This membrane protects the protein shell from human immune responses, enabling quasi- enveloped virus particles to spread in a stealthy fashion within the liver.
