Myelodysplastic

Question 1

Affects Elderly. med. age 70
env. hazards: benzene, petrochemicals
chromosomal anomolies: Trisomy 8, mono 7, L.A chromo 5,

Answer 1

Myelodysplastic neoplasms

Question 2

Oval macrocytes. Lots of RBC inclusions or weird morphology

Answer 2

Dyserythro

Question 3

neutropenia. hypogranule. psuedo dohle bodies. hybrid myelomono

Answer 3

Dysmyelo

Question 4

Thrombocytopenia. giant platelets. abnormal looking plt.

Answer 4

Dysmega

Question 5

Single lineage dys. blood: unicytopenia (usually RBC) BM: usually RBC, <15% sideroblasts.

Answer 5

MDS-SLD

Question 6

2 or more myeloid lineages (PMN/eryth/mega)

Answer 6

MDS-MLD

Question 7

Can be with SLD/MLD. >15% ringed sideroblasts

Answer 7

MDS-RS

Question 8

Excess blasts. blood: cytopenia, <5% blasts. BM: 5-9% blasts. Uni/multi-lineage dys

Answer 8

MDS-EB

Question 9

5-19% blasts in blood, 10-19% in BM. w or w/o auer rods. smouldering leukemia. DiDuglielmo.

Answer 9

MDS-EB2

Question 10

50% rbc precursors . <20% myeloblast with STL. also del 5q subset.

Answer 10

MDS-EB2-ML

Question 11

Myelo/mono. <20% blasts. WBC lower, but mostly mono,pro,grans,immature. Blasts: CMML1:<5% PB <10% BM. CMML2: 5-15% PB, 10-19% in BM

Answer 11

CMMoL